Dr. Gelfand graduated from the Moscow State University (MSU) with a degree in mathematics. Since then he worked in the fields of bioinformatics and molecular evolution and obtained the Candidate of Sciences degree in Mathematics and Biophysics from Institute of Theoretical and Experimental Biophysics, Pushchino, and then the Doctor of Sciences degree in Biology and Molecular Biology from Research Institute for Genetics and Selection of Industrial Microorganisms (GosNIIGenetika). Dr. Gelfand held research positions at Institute of Protein Research and at GosNIIGenetika, and the position of Director of Science at Integrated Genomics, Moscow. Today, Dr. Gelfand is Professor of Bioengineering and Bioinformatics at MSU, Vice-Director for Science at the Kharkevich Institute for Information Transmission Problems RAS (ITTP), and Head of IITP Research and Training Center of Bioinformatics.
Dr. Gelfand is a well-established bioinformatics specialist in the international scientific community. His research encompasses comparative genomics, systems biology, molecular evolution, transcriptomics, metagenomics. Currently he is studying co-evolution of transcription factors and their recognition sites, microevolution of bacterial genomes on the strain level, evolution of alternative splicing, three-dimensional structure of chromatin and epigenetics. Dr. Gelfand published the results of his research in major international scientific journals, such as Genome Research, Molecular Cell, Nature Communications, Molecular Systems Biology, Genome Biology, Trends in Genetics, Briefings in Bioinformatics, Proceedings of the National Academy of Science, Nucleic Acids Research, PLoS Genetics. His papers have been cited more than seven thousand times, and his Hirsch factor is 47.
Dr. Gelfand actively serves professional community: he is an elected member of Academia Europaea, Associate Editor of Journal of Computational Biology, member of editorial boards of peer-reviewed journals such as Journal of Bacteriology, Peer J, and Biology Direct, and referee for leading scientific journals. Dr.Gelfand also regularly serves on the Program Committees for international workshops and conferences on Genetics, Biophysics, and Bioinformatics.
Mikhail’s main research areas are systems biology, functional and comparative genomics.
His lab combines data on three-dimensional structure of chromatin, epigenetic state, and gene expression to obtain an integrated view of genome functioning in diverse eukaryotes, from human to amoebae. One more research direction is evolution of transcript splicing and editing. Comparative analysis of bacterial genomes yields numerous functional annotations of novel enzymes, transporters, and transcription factors; understanding of general principles of evolution of bacterial genomes and regulatory networks. Metagenomic studies are mainly performed in the areas of general or practical interest (coral disease, aphids, oil wells).
The course will touch upon both basics and some deeper topics of comparative genomics, including but not limited to homology and its relationship to function, horizontal gene transfer, genome rearrangements, pan-genomes, metagenomes, gene networks, and functional annotation of genes and proteins. The students will get an understanding of molecular evolution at the genome level and be able to apply this understanding to both theoretical and real-life molecular biology problems. “Nothing in Biology Makes Sense except in the Light of Evolution” (Theodosius Dobzhansky).
ФИО: Гельфанд Михаил Сергеевич
Занимаемая должность (должности): профессор
Преподаваемые дисциплины: нет
Ученая степень: кандидат физико-математических наук, 1993 г., Институт теоретической и экспериментальной биофизики РАН
Ученое звание (при наличии): доктор биологических наук, 1998 г.; профессор по биоинформатике, 2007 г.
Наименование направления подготовки и/или специальности:
Данные о повышении квалификации и/или профессиональной переподготовке (при наличии): есть
Общий стаж работы: более 20 лет
Стаж работы по специальности: более 20 лет