Supervisor: Dmitry Gorin
Vasiliy received his Bachelor degree in Biomedical Engineering with high honors (Magna Cum Laude) from the University of Utah, USA, in 2007, and then Masters and Ph.D. degrees in Chemical Engineering with a Golden Key honor from the same university in 2015. His undergraduate research focused on creating 3-D tissue models for endothelial cell growth under different physical and chemical conditions with the purpose of studying angiogenesis that is important in disease development and wound healing. Prior to pursuing his graduate degree, Vasiliy worked as a research associate in pharmaceutical companies. In the graduate school he became part of the NSF Integrative Graduate Education and Research Traineeship. His graduate school research included experiments coupled with mathematical modeling to study transport phenomena of molecules and nanoparticles that are important in a variety of applications. Towards the end of the graduate school, Vasiliy started studying endogenous nanoparticles, their membrane proteins and cargo, such as miRNA, mRNA and DNA that had been found to play a critical role in disease progression. He focused on studying their biophysical and chemical properties that would be useful for future disease screening and drug delivery.
Application of endogenous nanoparticles for disease diagnostics and treatment
Chernyshev V.S., Chuprov-Netochin R.N., Tsydenzhapova E, Van Devener B, Leonov S, Gorin D, Skliar M. Dynamic surface tension probe for measuring the concentration of extracellular vesicles. Biochem Biophys Res Commun. 609:189-194. (2022) doi: 10.1016/j.bbrc.2022.04.017.
Chernyshev, V.S., Skliar, M. Quantification of Desiccated Extracellular Vesicles by Quartz Crystal Microbalance. Biosensors 12, 371 (2022) https://doi.org/10.3390/bios12060371.
Kuzin, A., Chernyshev V., Kovalyuk V., An P., Golikov A., Ozhegov R., Gorin D., Gippius N., and Goltsman G., “Hybrid nanophotonic–microfluidic sensor for highly sensitive liquid and gas analyses,” Opt. Lett. 47, 2358-2361 (2022)
Novoselova M.V., German S.V., Abakumova T.O., Perevoschikov S.V., Sergeeva O.V., Nesterchuk M.V., Efimova O.I., Petrov K.S., Chernyshev V.S., Zatsepin T.S., Gorin D.A. Multifunctional nanostructured drug delivery carriers for cancer therapy: Multimodal imaging and ultrasound-induced drug release. Colloids and Surfaces B: Biointerfaces (2021).
Barmin R.A., Rudakovskaya P.G., Chernyshev V.S., Guslyakova O.I., Belcov P.A., Obukhova E.N., Gayer A.V., Shirshin E.A., Gorin D.A. Optoacoustic/Fluorescent/Acoustic Imaging Probe Based on Air-Filled Bubbles Functionalized with Gold Nanorods and Fluorescein Isothiocyanate. ACS Omega (2021).
Barmin R.A., Rudakovskaya P.G., Gusliakova O.I., Sindeeva O.A., Prikhozhdenko E.S., Maksimova E.A., Obukhova E.N., Chernyshev V.S., Khlebtsov B.N., Solovev A.A., Sukhorukov G.B., Gorin D.A. Air-filled bubbles stabilized by gold nanoparticle/photodynamic dye hybrid structures for theranostics. Nanomaterials(2021).
Nozdriukhin D., Besedina N., Chernyshev V., Efimova O., Rudakovskaya P., Novoselova M., Bratashov D., Chuprov-Netochin R., Kamyshinsky R., Vasiliev A., Chermoshentsev D., Dyakov S.A., Zharov V., Gippius N., Gorin D.A., Yashchenok A. Gold nanoparticle-carbon nanotube multilayers on silica microspheres: Optoacoustic-Raman enhancement and potential biomedical applications. Materials Science and Engineering C (2019).
Skliar, M., Chernyshev, V. S. Imaging of Extracellular Vesicles by Atomic Force Microscopy. J. Vis. Exp. (151), e59254, doi:10.3791/59254 (2019).
Merdalimova, A., Chernyshev, V., Nozdriukhin, D., Rudakovskaya, P., Gorin, D., Yashchenok, A. Identification and Analysis of Exosomes by Surface-Enhanced Raman Spectroscopy. Applied Sciences. 9. 1135. 10.3390/app9061135 (2019).
McQuin C., Goodman A., Chernyshev V., Kamentsky L., Cimini B.A., et al. CellProfiler 3.0: Next-generation image processing for biology. PLOS Biology 16(7): e2005970. https://doi.org/10.1371/journal.pbio.2005970 (2018)
*Nature Index Journal.
Skliar M., Chernyshev V.S., Belnap D.M., Sergey G.V., Al-Hakami S.M., Bernard P.S., Stijleman I.J., Rachamadugu R. Membrane proteins significantly restrict exosome mobility. Biochem Biophys Res Commun. doi: 10.1016/j.bbrc.2018.05.107. (2018)
Chernyshev V.S., Rachamadugu R., Tseng Y.H., Belnap D., Jia Y., Branch K., Butterfield A., Pease L., Bernard P., Skliar M. Size and shape characterization of hydrated and desiccated exosomes. Anal. Bioanal. Chem. 407, 3285-301 (2015)
Chernyshev V.S., Skliar M. Diffusivity measurements of solutes impacting interfacial tension. Ind. Eng. Chem. Res. 54, 4535-4544 (2015)
Jia Y., Chernyshev V.S., Skliar, M. Ultrasound measurements of segmental temperature distribution in solids: method and its high-temperature validation. Ultrasonics. doi:10.1016/j.ultras.2015.11.006 (2015)
Chernyshev V.S., Skliar M. Surface tension of water in the presence of perfluorocarbon vapors. Soft Matter. 10, 1937-1943 (2014)
Wyatt H.R., Ogden L.G., Cassic K.S., Hoagland E.A., McKinnon T., Eich N., Chernyshev V.S., Wood T., Cuomo J., Hill J.O. Successful internet-based lifestyle change program on body weight and markers of metabolic health. Obes.Weight Manag. 5,167-173 (2009)
Chemical Engineering, Ph.D. (University of Utah, 2015)
Chemical Engineering, M.Sc. (University of Utah, 2012)
Biomedical Engineering, B.Sc. (University of Utah, 2007)
Falling Walls Venture Finalist 2019
Astrazeneca Skolkovo Startup Challenge Finalist 2019
STRIP grant, July 2018
Golden Key International Honor Society, May 2015
Graduate Seed Grant, Chemical Engineering Department, University of Utah, May 2014 – May 2015
Graduate Research Fellowship, University of Utah, Sep 2013 – May 2014
Wayne Brown Fellowship, University of Utah, Jun 2010 – Jun 2012
NSF Integrative Graduate Education and Research Traineeship, Jun 2010 – May 2015
NSF Graduate Research Fellowship Program Honorable Mention, May 2010
Magna Cum Laude Honor, University of Utah, May 2007
UROP Sponsorship, University of Utah, Jan 2007 – May 2007
School of Biomedical Engineering Scholarship, University of Utah, Aug 2006 – May 2007
International Student Scholarship, University of Utah, Jan 2004 – May 2004