tinasheprincemaviza

Tinashe Prince Maviza

Junior Research Scientist
Center for Molecular and Cellular Biology

Supervisor: Petr Sergiev

Research advisor: Professor Petr Sergiev

Program entry year: 2019

Graduated from: Skoltech, Center of Life Sciences, 2019

Research project: The functional role of PrfH protein – a homolog of translation termination factors

Research interests: Drug discovery, Ribosomes, Translation, Antimicrobial Resistance, Molecular Biology, Structural Biology, Signalling

Academic mobility:

University: University of Hamburg, Hamburg, Germany

Laboratory: Wilson`s Lab https://www.chemie.uni-hamburg.de/institute/bc/arbeitsgruppen/wilson.html

Dates: 16.01.2019 – 06.04.2019

Industry Immersion:

Company: SIRIUS

Project: Searching for protection mechanisms against CRISPR-Cas bacterial systems

Publications:

  1. Alferova, V.A., Maviza, T.P., Biryukov, M.V., Zakalyukina, Y.V., Polshakov, V.I., Sergiev, P.V., Korshun, V.A. and Osterman, I.A., 2022. Characterization of a novel natural tetracenomycin reveals crucial role of 4-hydroxy group in ribosome binding. Biochimie. https://doi.org/10.1016/j.biochi.2022.10.016
  2. Paranjpe, M.N., Marina, V.I., Grachev, A.A., Maviza, T.P., Tolicheva, O.A., Paleskava, A., Osterman, I.A., Sergiev, P.V., Konevega, A.L., Polikanov, Y.S. and Gagnon, M.G., 2023. Insights into the molecular mechanism of translation inhibition by the ribosome-targeting antibiotic thermorubin. Nucleic Acids Research, 51(1), pp.449-462., https://doi.org/10.1093/nar/gkac1189
  3. Maviza, T.P.*; Zarechenskaia, A.S.*; Burmistrova, N.R.; Tchoub, A.S.; Dontsova, O.A.; Sergiev, P.V.; Osterman, I.A. RtcB2-PrfH Operon Protects E. coli ATCC25992 Strain from Colicin E3 Toxin. Int. J. Mol. Sci. 2022, 23, 6453. https://www.mdpi.com/1422-0067/23/12/6453
  4. Wieland, M., Holm, M., Rundlet, E. J., Morici, M., Koller, T. O., Maviza, T. P., Pogorevc, D., Osterman, I. A., Müller, R., Blanchard, S. C., & Wilson, D. N. (2022). The cyclic octapeptide antibiotic argyrin B inhibits translation by trapping EF-G on the ribosome during translocation. Proceedings of the National Academy of Sciences of the United States of America, 119(19), e2114214119. https://doi.org/10.1073/pnas.2114214119
  5. Alferova, V.A., Maviza, T.P., Biryukov, M.B., Zakalyukina, Y.B., Lukianov, D.A., Skvortsov, D.A., Vasilyeva, L.A., Tashlitsky, V.N., Polshakov, V.I., Dontsova, O.A. and Sergiev, P.V., 2021. Biological evaluation and spectral characterization of novel tetracenomycin X congener. https://doi.org/10.1016/j.biochi.2021.09.014
  6. Shiriaev, D.I., Sofronova, A.A., Berdnikovich, E.A., Lukianov, D.A., Komarova, E.S., Marina, V.I., Zakalyukina, Y.V., Biryukov, M.V., Maviza, T.P., Ivanenkov, Y.A. and Sergiev, P.V., 2021. Nybomycin inhibits both types of E. coli DNA gyrase–fluoroquinolone-sensitive and fluoroquinolone-resistant. Antimicrobial Agents and Chemotherapy. https://journals.asm.org/doi/abs/10.1128/AAC.00777-20
  7. Osterman, I.A.*, Wieland, M.*, Maviza, T.P.*, Lashkevich, K.A., Lukianov, D.A., Komarova, E.S., Zakalyukina, Y.V., Buschauer, R., Shiriaev, D.I., Leyn, S.A. and Zlamal, J.E., 2020. Tetracenomycin X inhibits translation by binding within the ribosomal exit tunnel. Nature Chemical Biology, 16(10), pp.1071-1077. https://www.nature.com/articles/s41589-020-0578-x

Conferences:

  1. Maviza, T.P.*; Zarechenskaia, A.S.*; Burmistrova, N.R.; Tchoub, A.S.; Dontsova, O.A.; Sergiev, P.V.; Osterman, I.A. RtcB2-PrfH Operon Protects E. coli ATCC25992 Strain from Colicin E3 Toxin. III ОБЪЕДИНЕННОМ НАУЧНОМ ФОРУМЕ ФИЗИОЛОГОВ, БИО-
    ХИМИКОВ И МОЛЕКУЛЯРНЫХ БИОЛОГОВ. 2022, http://rusbiochem.org/vii_syezd_biohimikov_rossii_.html. Delivered a Talk – Presenter.
  2. Alferova, V.A.; Maviza, T.P.; Biryukov, M.V.; Zakalyukina, Y.V.; Lukianov, D.A.; Skvortsov, D.A.; Vasilyeva, L.A.; Tashlitsky, V.N.; Polshakov, V.I.; Sergiev, P.V.; Osterman, I.A.; Korshun, V.A. Structure-activity relationship for natural tetracenomycin X congeners, in Proceedings of the 2nd International Electronic Conference on Antibiotics—Drugs for Superbugs: Antibiotic Discovery, Modes of Action And Mechanisms of Resistance, 15–30 June 2022, MDPI: Basel, Switzerland, doi:10.3390/eca2022-12695
  3. Tinashe P. Maviza, Anastasia S. Zarechenskaya, Dmitrii I. Shiriaev, Anna N. Slesarchuk, Polina A. Zotova, Olga A. Dontsova, Petr V. Sergiev, Ilya A. Osterman., 2021, September, The functional role of PrfH protein – a homolog of translation termination factors. EMBL – Protein Synthesis and Translational Control. Presenter
  4. D. Lukianov, I. Lisevich, V. Marina, M. Wieland, T. Maviza, E. Rasumova, A. Ferberg, M. TochilkinaI, O. IbitoyeI , V. Tashlitsky, V. Polshakov, S. Iarovenko, K. KomarovaI, D. Wilson, P. Sergiev, O. DontsovaI, I. Osterman., 2021, July Mechanism-based dual reporter screening system assists in identification of translational inhibitors. FEBS Conference . Link: https://2021.febscongress.org/abstract_preview.aspx?idAbstractEnc=4424170095092093094099424170

 

Abstracts:

  1. Alferova, V.A.; Maviza, T.P.; Biryukov, M.V.; Zakalyukina, Y.V.; Lukianov, D.A.; Skvortsov, D.A.; Vasilyeva, L.A.; Tashlitsky, V.N.; Polshakov, V.I.; Sergiev, P.V.; Osterman, I.A.; Korshun, V.A. Structure-activity relationship for natural tetracenomycin X congeners, in Proceedings of the 2nd International Electronic Conference on Antibiotics—Drugs for Superbugs: Antibiotic Discovery, Modes of Action And Mechanisms of Resistance, 15–30 June 2022, MDPI: Basel, Switzerland, doi:10.3390/eca2022-12695

  2. Osterman, I., Shiriaev, D., Sofronova, A., Khven, I., Lukianov, D., Komarova, E., Zakalyukina, Y., Maviza, T., Birykov, M., Ivanenkov, Y. and Sergiev, P., 2019, July. DNA replication machinery and topoisomerases-good targets for new antibiotics development. In FEBS OPEN BIO (Vol. 9, pp. 149-149). 111 RIVER ST, HOBOKEN 07030-5774, NJ USA: WILEY.

  3. Osterman, I.A., Komarova, E.S., Lukyanov, D.A., Khven, I.M., Shiriaev, D.I., Maviza, T.P., Veselov, M.S., Ayginin, A.A., Ivanenkov, Y.A., Bogdanov, A.A. and Sergiev, P.V., 2018, July. Mechanism-based antibiotic discovery platform. In FEBS OPEN BIO (Vol. 8, pp. 61-61). 111 RIVER ST, HOBOKEN 07030-5774, NJ USA: WILEY.

 

Grants:

  • Funding to I.A. Osterman: Russian Science Foundation (RSF 20-74-10031) for the project: “The functional role of PrfH protein – a homolog of translation termination factors”