evgenynikolaev

Evgeny Nikolaev

Prior to Skoltech, Evgeny was a professor of chemical physics and led the Laboratory of Ion and Molecular Physics at the Institute of Energy Problems of Chemical Physics of the Russian Academy of Sciences.

At the same time, he worked as the head of the Laboratory for Mass Spectrometry of Biomacromolecules at the Institute of Biochemical Physics of the Russian Academy of Sciences. Outside of that position, Evgeny was the lead scientific member of the Orehovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences. Previously he has researched at the Institute of Chemical Physics of the Russian Academy of Sciences.

Evgeny has also taken up organizational roles, serving as an organizer of the 8th European Conference on Mass Spectrometry and a member of the organizational committee for another European conferences on mass spectrometry. He has organized three Moscow conferences for schools on Mass Spectrometry, and participated as a member of the organizational committee for three international conferences on Genome, Proteomics, Bio-informatics, and Nanobiotechnology for Medicine. He has also organized the first International Skolkovo Conference for imaging with mass spectrometry.

His bachelor’s degree in molecular and chemical physics and his Ph.D. in chemical physics are from the Moscow Institute of Physics and Technology. He holds the title “doctor of science” from the Institute of Energy Problems of Chemical Physics of Russian Academy of Sciences.

Evgeny has been a visiting professor throughout the world: University Metz, France; University of Waterloo, Canada; University of Delaware, USA; University of Arizona, USA; and Purdue University, USA.

He is a member of the editorial board for the European Journal of Mass Spectrometry and Rapid Communications in Mass Spectrometry. He has advised 20 Ph.D. students at Moscow Institute of Physics and Technology. In all, he has published 162 articles and produced 35 patents.

Evgeny specializes in mass spectrometry and ion processes
as well as proteomics and petroliomics. His current research activities include supercomputer modeling of ion cloud behavior in accumulation and transportation of ions. Using mass spectrometry, he researches proteomes within physical liquids found in the human body through long isolation. He also develops the fundamental basis for quantitative analysis by mass spectrometry of the average copied proteins in the human body. Other research interests include analysis and classification of natural deposits of carbon through super-resolution mass spectrometry. He also develops and characterizes the dynamically harmonized Penning traps for Fourier Transform Ion Cyclotron Resonance Mass Spectrometry.

3D-printed, miniaturized Cassinian trap mass spectrometer for space research and general ambient analysis applications.

Objectives:
The goal of the project is the development of the new type of miniature mass spectrometer with high mass resolution, mass determination accuracy and low weight and power consumption primarily for space research applications and for broad application as carryable mass spectrometer for trace analyses of gases and molecular solids.

The approach is based on two new ideas:

Analyses of ion masses with Cassini trap type mass analyzer with sample ionization inside the trap

Making Cassini trap electrodes by high special resolution and accuracy 3D printing of conducting surfaces
The obvious benefit of this new approach is the possibility to print miniature mass spectrometry arrays to increase sensitivity of mass analyses and replicability of technology, which makes possible the production of cheap mass analyzers for different applications. The objectives are:
– Supercomputer simulations of electric field distribution in two centers Cassini traps.
– Supercomputer assisted simulation of the electron impact ionization processes inside the Cassini trap. Simulation of ion motion with initial conditions corresponding to the ionization region.

Results/current status
We have transported to the Skoltech a special vacuum camera for the assembly and test of the Cassini trap. Currently we are working on the purchasing of the required electronics.

Potential Impact
Mass spectrometry is one of the most informative and sensitive analytical technique, which is widely used in scientific research for more than 100 years and in Space research since 70th. The mission in 2015 to Churjumov-Gerasimenko comet had four mass spectrometer on board.  Regular mass spectrometer is a complex combination of mass analyzer with ion source and ion detector, sophisticated electronics and data recording system as well as vacuum system, which is the heaviest, the most power consuming and most expansive part of the whole instrument. Many planet satellites and comets does not have atmosphere and their research by mass spectrometers could be greatly simplified. The results of the project will considerably help to achieve this goal.

  • Honor issue International Journal of Mass Spectrometry (2012)
  • Medal from the Moscow government for Achievements in Science (1997)
  • Russian Academy Award for developing magneto-optical memory (1989)
Yury Kostyukevich
Yury Kostyukevich
Research Scientist
Gleb Vladimirov
Gleb Vladimirov
Research Scientist
kulashzhumadilova
Kulash Zhumadilova
MSc student
olegkharybin
Oleg Kharybin
Junior Research Scientist
alexanderzherebker
Alexander Zherebker
Junior Research Scientist
  • Biomedical Mass Spectrometry
This course introduces students to the first principles and methods of mass spectrometry with special emphasize on biological and medical applications. The course will cover wide range of mass spectrometry techniques used for ion generation, separation, detection and data processing and interpretation. The course will teach the theoretical fundamentals required for the design of instruments and methods for measuring mass spectra of biological samples. The course will cover mass spectrometry applications in OMICs technologies, mass spectrometry applications in biomarker discovery and tissue imaging.
After successful completion of this class, students will acquire the initial knowledge of the operational principles and design of different mass spectrometers, different methods of ionization of biological molecules of wide mass range, different methods of ion separation including magnetic sector, time of flight, RF and DC ion traps, as well as FTICR. Experimental and bioinformatics based methods of protein, peptides, lipids and metabolite molecule identification, different fragmentation methods for primary and secondary structure determination, methods of quantitative determination of proteins, lipids, metabolites and small molecule in physiological liquids