tatianaabakumova

Tatiana Abakumova

Junior Research Scientist
Center of Life Sciences

Associate Professor: Timofei Zatsepin

Tatiana Abakumova (Sandalova) was born in May 10, 1988. In 2012 she graduated from Pirogov Russian National Research Medical University. From December 2012 to May 2015 she worked as a Junior Researcher in the laboratory of neurochemistry in the department of fundamental and applied neurobiology in the Serbsky Medical Research Center of Psychiatry and Narcology, and then as a Researcher (May, 2015- May, 2016) and as a Senior Scientist (May, 2016- December, 2017) in immunochemistry laboratory in the same department (Head of laboratory – Prof. Vladimir P. Chekhonin). Since January 2018 she joined Skoltech as Junior Researcher to the group of professor Timofei Zatsepin.

Research interests of Tatiana Abakumova linked with targeted delivery of therapeutic and diagnostic agents to the brain (glioma, multiple sclerosis), synthesis of nanocontainers (micelles, nanogels, liposomes) and Gd-contrast agents. In January 2016 she got a Ph.D. in biochemistry with thesis «Targeted systems for MRI visualization of brain pathologies».

Tatiana Abakumova has a number of awards for her oral and poster presentations on the international conferences, including NANO2014 award for the best poster presentation among young scientists. She got scholarships from the Government of Russian Federation, funds and grants from different funds to support own research. She published 13 papers and 30 conference abstracts.

 

  • Development of the hepatocellular carcinoma fast model in mice
  • Magnetic nanoparticles and carbon nanotubes as enhancers for targeted RNA delivery in vivo
  1. Abakumov M.A., Grinenko N.F., Baklaushev V.P., Sandalova T.O., Nukolova N.V., Semenova A.V., Sokolsky-Papkov M, Vishvasrao H, Kabanov A.V., Chekhonin V.P. Tumor-specific contrast agent based on ferric oxide superparamagnetic nanoparticles for visualization of gliomas by magnetic resonance tomography Bull Exp Biol Med. 2012; 153(1) :89-93. IF= 0,456
  2. Abakumov M.A., Shein S.A., Vishvasrao H., Nukolova N.V., Sokol’ski-Papkov M., Sandalova T.O., Gubskii I.L., Grinenko N.F., Kabanov A.V., Chekhonin V.P. Visualization of experimental glioma C6 by MRI with magnetic nanoparticles conjugated with monoclonal antibodies to vascular endothelial growth factor. Bull Exp Biol Med. 2012; 154(2): 274-7. IF= 0,456
  3. Nukolova N.V., Baklaushev V.P., Abakumova T.O., Melnikov P.A., Abakumov M.A., Yusubalieva G.M., Bychkov D.A., Kabanov A.V., Chekhonin V.P.Targeted delivery of cisplatin by сonnexin 43 vector nanogels to the focus of experimental glioma C6. Bull Exp Biol Med. 2014; 157(4): 524-9. IF= 0,456
  4. Shein S.A., Nukolova N.V., Korchagina A.A., Abakumova T.O., Kiuznetsov I.I., Abakumov M.A., Baklaushev V.P., Gurina O.I., Chekhonin V.P. Site-directed delivery of VEGF-targeted liposomes into intracranial C6 glioma. Bull Exp Biol Med. 2015; 158(3): 371-6. IF= 0,456
  5. Abakumova T.O., Nukolova N.V., Gusev E.I., Chekhonin V.P. MRI contrast agents in diagnostics of multiple sclerosis. Zh Nevrol Psikhiatr Im S S Korsakova. 2015, 115(1):58-65.
  6. Abakumova T.O., Kuzkina A.A., Zharova M.V., Pozdeeva D.A., Gubskii I.L., Shepeleva I.I., Antonova O.M., Nukolova N.V., Kekelidze Z.I., Chekhonin V.P.Cuprizone Model as a Tool for Preclinical Studies of the Efficacy of Multiple Sclerosis Diagnosis and Therapy. Bull Exp Biol Med. 2015 Jun 2; 159(1):111-5 IF= 0,456
  7. Abakumov M.A., Nukolova N.V., Sokolsky-Papkov M., Shein S.A., Sandalova T.O., Vishwasrao H., Grinenko N.F., Gubsky I.L., Abakumov A.M., Kabanov A.V., Chekhonin V.P. VEGF-targeted magnetic nanoparticles for MRI visualization of brain tumor. Nanomedicine. 2015 May;11(4):825-33
  8. Abakumova T.O., Abakumov M.A., Shein S.A., Chelushkin P.S., Bychkov D.A., Mukhin V.Y., Yusubalieva G.M., Grinenko N.F., Kabanov A.V., Nukolova N.V., Chekhonin V.P. Connexin 43-targeted T1-contrast agent for MRI diagnostics of glioma. Contrast media and molecular imaging, 2016, 11(1):15-23 Impact factor = 3.307
  9. Shein S.A, Kuznetsov I.I., Abakumova T.O., Chelushkin P.S., Korchagina A.A., Bychkov A., Seregina I.F., Bolshov M.A., Kabanov A.V., Chekhonin V.P., Nukolova N.V. VEGF and VEGFR2-targeted Liposomes for Cisplatin Delivery to Glioma Cells Molecular Pharmoceutics, 2016, 13(11):3712-3723 IF = 4,44
  10. Voeikov R.V., Abakumova Т.О., Grinenko N.Ph., Melnikov P.A., Bespalov V.A., Stukov S., Chekhonin V.P., Klyachko N.L. and Nukolova N.V. Dioxadet–loaded nanogels as a potential formulation for glioblastoma treatment. Journal of Pharmaceutical Investigation,  47(1), pp 75–83
  11. Baklaushev VP, Kilpeläinen A, Petkov S, Abakumov MA, Grinenko NF, Yusubalieva GM, Latanova A A, Gubskiy IL, Zabozlaev FG, Starodubova E, Abakumova TO, Isaguliants MG, Chekhonin V.P. Luciferase expression allowa bioluminescence imaging but imposes limitations on the orthotopic mouse (4T1) model of breast cancer. Scientific Reports 7, Article number: 7715 (2017); IF  = 4,259
  12. V. Nukolova, A.D. Aleksashkin, T.O. Abakumova, A.Y. Morozova, I.L. Gubskiy, Е.А. Kirzhanova, M.A. Abakumov, V.P. Chekhonin, c, N.L. Klyachko, A.V. Kabanov Multilayer polyion complex nanoformulations of superoxide dismutase 1 for acute spinal cord injury Journal of Controlled Release, volume 270, 28 January 2018, Pages 226-236 IF = 7,56
  13. Semkina A.S.; Abakumov M.A., Skorikov A.S.; Abakumova T.O., Melnikov P.A., Grinenko N.F.; Cherepanov S.A., Vishnevskiy D.A.; Naumenko V.A.; Ionova K.P., Majouga, A.G., Chekhonin V.P. Multimodal doxorubicin loaded magnetic nanoparticles for VEGF targeted theranostics of breast cancer. Nanomedicine: Nanotechnology, Biology, and Medicine, 2018 IF = 5.7 (accepted)

2006-2012                  M.Sc., Pirogov Russian National Research Medical University, Department of Medical Biology, Department of Medical Nanobiotechnology

2012-2015                  Ph.D. in Biology “Gd-based contrast agent for MRI diagnosis of glioma and demyelination” (Scientific advisor Prof. Vladimir P. Chekhonin)

2016                            Сertified advanced training program  «Modern animal facility and experimental work with SPF animals»

targeted delivery of nanoparticles, blood-brain barrier permeability, MRI contrast agents, gadolinium, iron oxide nanoparticles, monoclonal antibodies, animal models, glioma c6, multiple sclerosis

2011 Second Award at the 6th International Pirogov Scientific Conference of Students and Young Scientists in Moscow

2012 First Award at 7th International Pirogov Scientific Conference of Students and Young Scientists; Third Award, International conference «Biotechnology Biotechnology: State of the Art and Prospects of Development” in Moscow; Second Award, 19th International Scientific Conference of Students and Young Scientists «Lomonosov»; Award, 3rd International Congress on “Biomaterials and Nanobiomaterials: Recent Advances Safety – Toxicology and Ecology Issues” in Heraclion, Greece; Scholarship of the “Green Light” fund; Scholarship of the government of the Russian Federation

2013 Award of «Invitro» company

2014 Fellowship of the 10th International Symposium of Polymer Therapeutics in Valencia, Spain, Winner of Young Scientist Award, 12th International Conference on Nanostructured Materials (NANO), July 13-18, 2014

2015 First Place Award for poster presentation, conference “Magnetic nanoparticles in biology and medicine”, Zvenigorod