sergeyshmakov

Sergey Shmakov

Research Scientist
Center of Life Sciences

Professor: Konstantin Severinov

 

PhD Thesis Defense: October 16, 2017, Skoltech

PhD program: Life Sciences

Thesis title: “Computational approaches for discovery of novel CRISPR-Cas systems”

Supervisor : Professor Konstantin Severinov.

Сo-advisor: – Eugene Koonin

 

Bioinformatic prediction and analysis of novel CRISPR-Cas systems and their components

https://www.ncbi.nlm.nih.gov/pubmed/?term=sergey+shmakov+CRISPR

Science. 2016 Aug 5;353(6299):aaf5573. doi: 10.1126/science.aaf5573. Epub 2016 Jun 2.

C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector.

Abudayyeh OO, Gootenberg JS, Konermann S, Joung J, Slaymaker IM, Cox DB, Shmakov S, Makarova KS, Semenova E, Minakhin L, Severinov K, Regev A, Lander ES, Koonin EV, Zhang F.

Front Microbiol. 2016 Mar 31;7:398. doi: 10.3389/fmicb.2016.00398. eCollection 2016.

Metagenomic Analysis of Bacterial Communities of Antarctic Surface Snow.

Lopatina A, Medvedeva S, Shmakov S, Logacheva MD, Krylenkov V, Severinov K.

 

Genome Biol Evol. 2016 Jan 13;8(2):375-86. doi: 10.1093/gbe/evw006.

Recent Mobility of Casposons, Self-Synthesizing Transposons at the Origin of the CRISPR-Cas Immunity.

Krupovic M, Shmakov S, Makarova KS, Forterre P, Koonin EV.

Mol Cell. 2015 Nov 5;60(3):385-97. doi: 10.1016/j.molcel.2015.10.008. Epub 2015 Oct 22.

Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems.

Shmakov S, Abudayyeh OO, Makarova KS, Wolf YI, Gootenberg JS, Semenova E, Minakhin L, Joung J, Konermann S, Severinov K, Zhang F, Koonin EV.

 

Nucleic Acids Res. 2014 May;42(9):5907-16. doi: 10.1093/nar/gku226. Epub 2014 Apr 11.

Pervasive generation of oppositely oriented spacers during CRISPR adaptation.

Shmakov S, Savitskaya E, Semenova E, Logacheva MD, Datsenko KA, Severinov K

NIH Director award 2016: “For his work on discovery and functional classification of diverse Class 2 CRISPR-Cas systems”