rupertgerzer

Rupert Gerzer

Professor, Provost, Director of the Skoltech Center for Translational Biomedicine
Center for Translational Biomedicine
Space Center

Dr Rupert Gerzer is a medical doctor by education, whose scientific interests lie in medicine, life sciences and astronautics. Prior to joining Skoltech in 2015, he was Professor and Chairman at the Institute of Aerospace Medicine (Aachen University) and Director of the Institute of Aerospace Medicine, German Aerospace Center DLR (Cologne) – Western Europe’s largest civil institute of aerospace medicine.

Prof Gerzer studied medicine at the University of Munich. After that, he was postdoctoral fellow at the Institute of Pharmacology, University of Heidelberg (1977-1981), and then visiting scientist at Vanderbilt University, Nashville, TN, USA (1981-1983).  Before obtaining a Heisenberg professorship at the University of Munich in 1988, Prof. Gerzer was also a resident in Internal Medicine at the University of Munich. In 1992, he was appointed Director of Institute of Aerospace Medicine, German Aerospace Center DLR in Cologne and full Professor and Chairman of Aerospace Medicine at Aachen University. Otherwise, he held or continues to hold various senior positions in professional organizations in the fields of medicine and space, including German Society of Health Telematics, Medical Advisory Committee to the German Minister of Defense, German Academy of Aerospace Medicine, Advisory Committee of the European Astronaut Centre, and the Acta Astronautica journal. His professional affiliations extend far beyond this list. Prof. Gerzer published more than 250 scientific papers with h-Index 41 (Google Scholar) and received the Life Science Award of the International Academy of Astronautics in 2003.

Prof Gerzer has co-founded the commercial company TEMOS International GmbH (global hospital evaluations).

 

  • medicine
  • life sciences

1979

1.        GerzerR, Loeschke K (1979) Decreased cyclic GMP levels in rat cecum mucosa during adaptive stimulation of Na-K-ATPase.Experientia35: 197-199

1981

2.         Blümel P,GerzerR, Loeschke K (1981) Evidence against cyclic GMP acting as a direct  modulator of active sodium absorption in rat cecum.Experientia37:123-125

3.        GerzerR, Hofmann F, Schultz G (1981) Purification of a soluble, sodium nitroprusside-stimulated         guanylate cyclase from bovine lung.Eur.J.Biochem. 116:479-486

4.        GerzerR, Hofmann F, Ivanova K, Spies C, Böhme E, Schultz G (1981) Purification of soluble   guanylate cyclase without loss of stimulation by sodium nitroprusside.Adv.Cyclic Nucleotide     Res.14:255-261

5.        Gerzer R, Böhme E, Hofmann F, Schultz G (1981) Soluble guanylate cyclase purified from bovine lung contains heme and copper.FEBS Lett.132:71-74

1982

6.         Schultz G, Aktories K, Böhme E,GerzerR, Jakobs KH (1982) Signal transformation mediated by membrane receptors for hormones and neurotransmitters.Molecul.Immunol.19:1207-1214

7.        Gerzer R, Radany EW, Garbers DL (1982) The separation of the heme and apoheme forms of soluble guanylate cyclase.Biochem.Biophys.Res.Commun.108:678-686

1983

8.         Böhme E,GerzerR, Grossmann G, Herz J, Mülsch A, Spies C, Schultz G (1983) Regulation of soluble guanylate cyclase activity. In:HormonesandCellRegulation. Vol. 7. ed. by J.E.        Dumont, J, Nunez, and R. Denton. Elsevier Holland; 147-161

9.        Gerzer R, Hamet P, Ross AH, Lawson JA, Hardman JG (1983) Ca++-induced release from  platelet membranes of fatty acids that modulate soluble guanylate cyclase.J.Pharmacol.Exp. Ther.226:180-186

10.       Radany EW,GerzerR, Garbers DL (1983) Purification and characterization of particulate  guanylate cyclase from sea urchin spermatozoa.J.Biol.Chem.258:8346-8351

 1985

11.       Tremblay J,GerzerR, Vinay P, Pang SC, Beliveau R, Hamet P (1985) The increase of cGMP by atrial natriuretic factor correlates with the distribution of particulate guanylate cyclase.FEBS Lett.        181:17-22

12.      GerzerR(1985) Das Herz, ein endokrines Organ: Die Entdeckung eines neuen Hormons  (The discovery of a new hormone).  KlinischeWochenschrift63:529-536

13.      GerzerR, Witzgall H, Tremblay J, Gutkowska J, Hamet P (1985) Rapid increase in plasma and urinary cGMP after bolus injection of atrial natriuretic factor in man.J.Clin.Endocrinol.Metab.    61:1217-1219

14.       Weil J, Lang RE, Suttmann H, Rampf U, Bidlingmeier F,GerzerR(1985) Concomitant increase in plasma atrial natriuretic peptide and cyclic GMP in man during volume loading.Klinische   Wochenschrift63:1265-1268

 1986

15.       Tremblay J,Gerzer R, Pang SC, Cantin M, Genest J, Hamet P (1986) ANF stimulation of detergent-dispersed particulate guanylate cyclase from bovine adrenal cortex.FEBS Lett    194:210-214

16.      Gerzer R, Brash AR, Hardman JG (1986) Activation of soluble guanylate cyclase by arachidonic acid and 15-lipoxygenase products.Biochim.Biophys.Acta886:383-389

17.       Loeschke K, Farack UM,GerzerR, Keravis T (1986) cAMP-Konzentrationen, cAMP-Umsatz und Flüssigkeitssekretion am Jejunum, Ileum und Colon der Ratte unter Choleratoxin (cAMP concentration, cAMP turnover and fluid secretion in the jejunum, ileum and colon of rats under cholera toxin). Z.    Gastroenterol.(Suppl. 3) 24:57-61

18.      GerzerR, Weil J, Strom T, Müller T (1986) Mechanisms of action of atrial natriuretic factor: Clinical consequences.KlinischeWochenschrift64 (Suppl. VI):21-26

 1987

19.      GerzerR, Heim JM, Schütte B, Weil J (1987) Cellular mechanisms of action of atrial natriuretic factor.KlinischeWochenschrift65 (Suppl. VIII):109-114

20.       Karrenbrock B, Grewe R, Loeschke K,GerzerR(1987) Comparaison des effets du SIN-1, du    nitroprussiate de sodium et des derives nitres sur l’inhibition de l’agregation plaquettaire et l’activation de la guanylate-cyclase soluble plaquettaire (Comparison of the effects of SIN-1, Sodium nitroprusside and its nitrated derivatives on the inhibition of platelet aggregation and activation of platelet soluble guanylete cyclase). PathologieBiologie35:251-254

21.       Haufe MC, Weil J, Nafzger K,GerzerR, Bidlingmaier F, Theisen K (1987) Acute increase in right  atrial pressure by intracardiac stimulation releases atrial natriuretic peptide.Eur.Heart J.8:277-  281

22.       Weil J,GerzerR, Döhlemann C, Bühlmeyer K, Bidlingmaier F, Strom T, Lang RE (1987) Atrial    natriuretic peptide and cyclic GMP levels in healthy children and in children with cardiac diseases. in:Amer. Soc. Hypertens. Symp. Ser Vol 1: Biologically active atrial peptides;   eds: BM Brenner and JH Laragh; Raven Press New York: 531-534

23.       Weil J,GerzerR, Strom T, Lang RE, Döhlemann C, Knorr D, Bidlingmeier F (1987) Increased  plasma cyclic GMP concentrations in children with high levels of circulating atrial natriuretic peptide. Pediatrics80:545-548

24.       Heim JM, Weil J, Idzikowski M, Maimer H,GerzerR(1987) Cyclisches GMP, ein biologischer Marker der ANF-Wirkung (Cyclic GMP, a biological marker of ANF effects). In: Bussmann, Kreye (ed.):Atriales natriuretisches Peptid und das   kardiovaskuläre System.Steinkopff-Verlag, Darmstadt 87-95

25.       Weil J, Heim JM, Döhlemann C, Bühlmeyer,GerzerR(1987) Konzentrationen des atrialen natriuretischen Peptids und von cGMP im Plasma und Urin von herzkranken Kindern (Concentration of atrial natriuretic peptide and of cGMP in plasma and urine of children with heart disease). In: Bussmann, Kreye (ed.):Atriales natriuretisches Peptid und das kardiovaskuläre System.       Steinkopff-Verlag, Darmstadt 139-148

26.       Haufe M, Weil J,GerzerR, Theisen K (1987) Akute rechtsatriale Drucksteigerung durch intrakardiale Stimulation erhöht den atrialen natriuretischen Faktor (ANF) (Acute right atrial pressure increase by intracardiac stimulation increases the levels of atrial natriuretic factor (ANF)). In: Bussmann, Kreye (ed.):Atriales natriuretisches Peptid und das kardiovaskuläre System.Steinkopff-Verlag,   Darmstadt 149-157

27.       Kreye VAW, Jungmann E, Kurtz A, Kirchheim HR, Forssmann WG, Vierhapper H, Arendt RM,   Gerzer R, Hartter E (1987) Zur Rolle des atrialen natriuretischen Peptids: Versuch einer Standortbestimmung (Status quo of the role of atrial natriuretic peptide). In: Bussmann, Kreye (ed.):Atriales natriuretisches Peptid und das          kardiovaskuläre System.Steinkopff-Verlag, Darmstadt 227-230

28.       Weil J, Strom TM, Brangenberg B, Sebening W, Haufe M, Lang RE, Bidlingmeier F,GerzerR  (1987) Plasma atrial natriuretic peptide levels in children with cardiac diseases: Correlation with  cGMP levels and haemodynamic parameters.HormoneRes. 28:64-70

29.       Müller T, Heim JM, Weil J, Wehling M, Witzgall H,GerzerR(1987) Effects of clonidine and  dihydralazine on plasma ANF- and cyclic GMP levels in man during volume loading.J. Cardiovasc.Pharmacol. 10 (Suppl. 12):163-166

30.       Stangl K, Weil J, Seitz K,Gerzer R, Wirtzfeld A, Roth G, Laule M, Blömer H (1987) Atrial natriuretic peptide (ANP): influence of av-synchrony on the ANP plasma levels in patients with      total av-block. In: B. Belhassen, S. Feldman, Y. Copperman (Ed.)Cardiac Pacing and          Electrophysiology.Proc. VIIIth World Symp. on Cardiac Pacing and Electrophysiology, 253-259

31.       Weil J, Heim J-M, Brügmann M, Strom TM, Haufe M,Gerzer R(1987) Influence of ANP on fluid homeostasis in infants: Measurement of ANP and cGMP levels in plasma and urine.Amer. Soc. Hypertension Symposium Series, Vol. II

32.       Maimer H, Heim JM, Weil J,GerzerR(1987) The “ANF test”: cGMP responses to injected ANF. in: Biologically active atrial peptides.Amer. Soc. Hypertension Symposium Series, Vol. II

 1988

33.       Haufe MC,  Weil J,Gerzer R,Ernst JE, Theisen K (1988) Effects of repeated increments in right  atrial pressure on secretion of atrial natriuretic factor.Amer. J. Cardiol.61:932-934

34.       Heim JM, Ivanova K,Gerzer R(1988): Amiloride increases the sensitivity of particulate guanylate cyclase to atrial natriuretic factor.Biochem. Biophys. Res. Commun.152:1263-1268

35.      Gerzer R, Stromeyer H, Lang RE, Riepl R, Heim J-M, Drummer C(1988) Changes in hormonal   parameters during parabolic flight – Preliminary results.ESA Proceedings on Parabolic Flights

36.       Heim JM, Gottmann K, Weil J, Haufe MC,Gerzer R(1988) Is cyclic GMP a clinically useful  marker for ANF?Z. Kardiol.77 (Suppl 2):41-46

37.       Weil J, Strom TM, Heim J-M, Lang RE, Schindler M, Haufe M, Vogel M,Gerzer R(1988) Influence of diurnal rhythm, posture and right atrial size on plasma atrial natriuretic peptide levels.Z. Kardiol.77 (Suppl 2):36-40

38.       Haufe MC, Gerzer R, Weil J, Ernst J, Theisen K (1988) Verapamil impairs secretion of atrial  natriuretic factor in man.J. Amer. Coll. Cardiol.11:1199-1203

39.       Gerbes AL, Arendt RM,Gerzer R, Schnizer W, Jüngst D, Paumgartner G, Wernze H (1988) Role  of atrial natriuretic factor, cyclic GMP and the renin-aldosterone system in acute volume  regulation of healthy human subjects.Eur. J. Clin.Invest.18:425-429

40.       Farack UM,GerzerR, Keravis TM, Loeschke K (1988) Discrepancy between effects of cholera toxin on net fluid movement and on cAMP levels in rat jejunum, ileum, and colon.Dig. Dis. Sci. 33:1153-1158

41.       Tremblay J,GerzerR, Hamet P (1988) Cyclic GMP in cell function.Adv.Sec. Mess.     Phosphoprot. Res.22:319-383

42.      Gerzer R, Karrenbrock B, Heim JM (1988) Direct comparison of the effects of nitroprusside, SIN 1 and various nitrates on platelet aggregation and soluble guanylate cyclase activity.Thrombosis Research52:11-21

43.       Strom TM, Weil J, Braun F, Stangl K, Timnik A, Heim JM,Gerzer R(1988):Binding sites for atrial natriuretic peptide on platelets in patients with congestive cardiomyopathy.Eur. J. Clin. Invest.18:524-528

44.       Timnik A, Weil J, Brügmann M, Strom T, Haufe M, Heim JM,Gerzer R(1988) Atrial natriuretic    peptide in term newborn infants. In: WG Forssmann, DW Scheuermann, J Alt (eds):Functional anatomy of the endocrine heart. Steinkopff-Verlag Karlsruhe, 205-210

45.      Gerzer R(1988) Wirken Nitrate an Thrombozyten? (Do nitrates work on platelets?)CorVas5/6:260-262

46.       Graber SE, Clancey MA, Wells JN,Gerzer R(1988) A novel mechanism of soluble guanylate    cyclase stimulation: Time-dependent activation by bacterial lipopolysaccharide in rat fetal spleen cells. Biochim. Biophys. Acta972:331-338

47.       Arendt RM,Gerzer R, Millan MJ, Pooth R (1988) Physiologie, Pharmakologie und mögliche      klinische Bedeutung des atrialen natriuretischen Faktors (Physiology, pharmacology and possible clinical importance of atrial natriuretic factor). Lancet (deutsch), Suppl. Nov.:8-15

48.      Gerzer R(1988) Die mögliche Bedeutung des atrialen natriuretischen Faktors und von cGMP in Schwerelosigkeit (The possible importance of atrial natriuretic factor and of cGMP in microgravity).Tagungsband BMFT-DFVLR-StatusseminarForschung unter  Schwerelosigkeited.: K. Kreuzberg, P. Preu, 295-298

49.       Stangl K, Weil J, Seitz K,GerzerR, Wirzfeld A, Roth G, Laule M, Blömer H (1988) Atrial natriuretic peptide (ANP): Influence of AV synchrony on the ANP plasma levels in patients with     total AV-block.Pace11:1176-1181

50.       Ivanova K, Heim J-M, Lückenga B, Gerzer R(1988) The sensitivity of particulate guanylate cyclase to ANF is increased by amiloride and Triton-X-100.Amer. Soc. Hypertension   Symposium Series, Vol. III

 1989

51.       Heim J-M, Gottmann K, Weil J, Strom TM,Gerzer R(1989) Effects of a bolus dose of atrial natriuretic factor in young and elderly volunteers.Eur. J. Clin.Invest.19:265-271

52.       Heim J-M, Kiefersauer S,Gerzer R(1989)Urodilatin and ß-ANF: Binding properties and activation of particulate guanylate cyclase.Biochem. Biophys. Res. Commun.163:37-41

53.       Stalla GK, Stalla J, v. Werder K, Müller, OA,Gerzer R, Höllt V, Jakobs KH (1989) Nitroimidazole derivatives inhibit anterior pituitary cell function by a direct effect on the catalytic subunit of the adenylate cyclase holoenzyme.Endocrinology125:699-706

54.       Haufe MC,  Weil J, Heim J-M, Ernst JE,Gerzer R, Theisen K (1989) Hämodynamische und medikamentöse Beeinflussung der stimulierten ANF-Sekretion (Hemodynamic and medical influence of stimulated ANF secretion).Z. Kardiol.78:532-537

55.      Gerzer R, Drummer C, Lang R, Weil J, Stromeyer H (1989) Regulation of volume homeostasis in weightlessness: Possible involvement of atrial natriuretic factor and cyclic GMP.Proc. 1. Experimenters Working Group Meeting D-2, “Research Program of the German Spacelab    Mission D-2″, Aachen 30-31.10.89, p372-376

56.      GerzerR(1989) Erkrankungen mit Beteiligung der Hormone des Herzens (Diseases with involvement of cardiac hormones). Invited Chapter:        Klinik der Gegenwart-Endokrinologie Vol. B , ed: R.D. Hesch, Urban & Schwarzenberg,     1017-1027

57.       Wehling M, Müller T, Heim J-M, Witzgall H, Weil J, Lorenz R,Gerzer R(1989) Atrial natriuretic    factor and cyclic guanosine monophosphate: Involvement in hemodynamic and hormonal effects  of clonidine and dihydralazine in man?J. Appl. Physiol.67:938-944

58.       Müller-Esch G, Potratz J, Kentsch M, Ball P,Gerzer R, Klohs S, Lawrenz R, Scriba PC (1989)   Atrial natriuretic peptide in normal humans: Hemodynamic and renal effects after single and      repeated bolus injection. in: Progr. in:Atrial Natriuretic Peptide Res. 3, ed. by BM Brenner and       JH Laragh, Raven Press, NY, p155-167

59.       Kentsch M, Müller-Esch G, Ludwig D, Potratz J, Ball P,Gerzer R, Scriba PC (1989)    Hemodynamic and diuretic effects of two consecutive bolus applications of atrial natriuretic          peptide (_-hANP) in healthy volunteers. in:Endocrinology of the heart, ed. by W. Kaufmann        and G. Wambach, Springer-Verlag Berlin, p178-181

60.      Gerzer R, Drummer C, Karrenbrock B, Heim J-M (1989) Inhibition of PAF-induced platelet aggregation by molsidomine, SIN-1 and nitrates in vitro and ex vivo.J. Cardiovasc. Pharmacol.         14(Supp 11):S115-S119

61.       Schultes I,Gerzer R, Altenkirch H-U, Kirsch KA, Heyduck B, Röcker L (1989) Das Verhalten des  atrialen natriuretischen Faktors, der klassischen volumenregulierenden Hormone, der     Plasmaproteine und des Plasmavolumens bei einem Marathonlauf (Atrial natriuretic factor, classical volume regulating hormones, plasma proteins and plasma volume during marathon) . Proc. 31. Deutscher Sportärztekongr. Hannover 1988:Sport: Rettung oder Risiko für die Gesundheit, ed.:Böning D,  Braumann KM, Busse MW, Maassen N, Schmidt W, Dt. Ärzteverlag, 94-98

 1990

62.       Karrenbrock B, Heim J-M,Gerzer R(1990) Effect of molsidomine on ex vivo platelet aggregation  and plasma guanosine 3′,5′-cyclic monophosphate levels in healthy volunteers.Klin. Wochenschrift68:213-217

63.       Wehling M, Zimmermann J, Weil J,Gerzer R, Theisen K (1990) Renale Wirkungen von   Ibopamin im Vergleich mit Furosemid bei Patienten mit milder Herzinsuffizienz (Renal effects of Ibopamine in comparison to furosemide in patients with mild cardiac failure). Z. Kardiol. 79:120-125

64.       Lauster F,Gerzer R, Weil J, Fülle H-J, Schiffl H (1990) Assessment of dry body-weight in hemodialysis patients by the biochemical marker cGMP.Nephrology, Dialysis and Transplantation5:356-361

65.      Gerzer R, Karrenbrock B, Drummer C, Heim J-M (1990) Hemmung der   Thrombozytenaggregation durch EDRF-ähnliche Wirkstoffe (Inhibition of platelet aggregation by agents similar to EDRF). Medizinische Klinik85(Supp 1):18-22

66.       Heer M, Drummer C, Baisch F,Gerzer R, Maass H, Blomqvist G (1990) Effects of 10 days HDT on fluid and electrolyte metabolism.The Physiologist33:S165-S166

67.       Heim J-M, Gottmann K, Weil J, Schiffl H, Lauster F, Loeschke K,Gerzer R(1990) Effects of a small bolus dose of ANF in healthy volunteers and in patients with volume retaining disorders. Klin. Wochenschrift68:709-717

68.       Stangl K, Baumann G, Weil J,Gerzer R, Kerscher M, Blömer H (1990) Akute Senkung erhöhter ANP- und cGMP-Spiegel bei Patienten mit chronischer Herzinsuffizienz durch beta-adrenerge  Stimulation mit Dopexamin-Hydrochlorid. Korrelation zu hämodynamischen Parametern (Acte decrease of ANF and cGMP levels in patients with chronic cardiac failure by beta adrenergic stimulation with Dopexamine-hydrochloride). Z. Kardiol.79:417-423

69.       Drummer C, Stromeyer H, Riepl R, König A, Strollo F, Lang RE, Maass H, Röcker L,Gerzer R(1990) Hormonal changes during parabolic flight. Implications for the development of motion     sickness.Aviat. Space Environm.Med.61:821-828

70.       Ivanova K, Heim J-M,Gerzer R(1990) Kinetic characterization of atrial natriuretic factor- sensitive particulate guanylatecyclase.Eur. J. Pharmacol.189:317-326

71.       Altenkirch H-U, Gerzer R, Kirsch KA, Weil J, Heyduck B, Schultes I, Röcker L (1990) Effect of prolonged physical exercise on fluid regulating hormones.Eur. J. Appl. Physiol.61:209-213

72.       Drummer C, Heer M, Molz B, Schloßberger M, Stadeager C, Röcker L, Norsk P, Strollo F, Baisch         F, Warberg J, Christensen N-J, Norsk P, Gerzer R(1990) Physiology of body water and salt   regulation part I: Circadian rhythms of endocrine systems and urinary electrolyte excretion in   humans.Proc, 4th Eur. Symp. Life Sci Res. in Space (ESA SP-307):95-98

73.       Drummer C, Heer M, Molz B, Schloßberger M, Stadaeger C, Röcker L, Norsk P, Strollo F, Warberg J, Christensen N-J,Gerzer R(1990) Physiology of body water and salt regulation part II:   Volume and electrolyte homeostasis after an acute saline infusion. Proc, 4th Eur.Symp. Life Sci Res. in Space (ESA SP-307):99-102

74.       Lauster F,Gerzer R, Fülle H-J, Schiffl H, Weil J (1990) Klinische Wertigkeit von ANP und cGMP als Maß für die Flüssigkeitsüberladung bei chronischer Hämodialyse (Clinical importance of ANP and cGMP as measure of fluid overload in chronic dialysis). Labormedizin13:719-724

75.       Goetz K, Drummer C, Zhu JL, Leadley R, Fiedler F,Gerzer R(1990) Evidence that urodilatin, rather than ANP, regulates renal sodium excretion.J. Amer. Soc. Nephrol.1:867-874

76.       Drummer C, Lang RE, Baisch F, Blomqvist G, Heer M,Gerzer R(1990) Effects of saline loading during head down tilt on ANP and cyclic GMP levels and on urinary fluid excretion. Acta Astronautica23:25-29

 1991

77.       Fülle H-J, Heim J-M,Gerzer R(1991) Functional modulation of atrial natriuretic factor-sensitive particulate guanylate cyclase by redox mechanisms.Eur. J. Pharmacol.206:69-75

78.       Drummer C, Fiedler F, König A,Gerzer R(1991) Urodilatin, a kidney-derived natriuretic factor, is excreted with a circadian rhythm and stimulated by saline infusion in man.J. Amer. Soc. Nephrol.1:1109-1113

79.       Endres S, Fülle H-J, Sinha B, Stoll D, Dinarello CA,Gerzer R, Weber PC (1991) Cyclic nucleotides differentially regulate the synthesis of tumour necrosis factor-_ and interleukin-1ß by human mononuclear cells.Immunology72:56-60

80.       Mülsch A,Gerzer R(1991) A preparative polyacrylamide gel electrophoresis apparatus for the purification of guanylate cyclases.Methods in Enzymology195:355-363

81.       Mülsch A,Gerzer R(1991) Purification of heme-containing soluble guanylate cyclase. Methods in Enzymology195:377-383

82.       Drummer C, Valta-Seufzer U, Karrenbrock B, Heim J-M,Gerzer R(1991) Comparison of anti platelet properties of molsidomine, isosorbide-mononitrate and placebo in healthy volunteers. Eur. Heart J.12:541-549

83.       Fülle H-J, Endres S, Sinha B, Stoll D,Weber PC,Gerzer REffects of SIN-1 on cytokine  synthesis in human mononuclear cells.J. Cardiovasc. Pharmacol. 17(Suppl. 3):S113-S116

84.       Drummer C, Valta-Seufzer U, Spannagl M, Frey A, Lüdke S, Schramm W,Gerzer R(1991) Thrombozyten-Aggregation und Fibrinolyse bei gesunden Probanden unter Molsidomin, Isosorbid-5-Mononitrat und Placebo (Platelet aggregation and fibrinolysis in healthy subjects under molsidomine, isosorbide-5-mononitrate and placebo). Z. Kardiol.(Supp 5):43-46

85.      Gerzer R, Karrenbrock B, Niederreiter B, Heim J-M, Drummer C (1991) Thrombozytenaggregation unter SIN 1: Vergleich mit Isosorbid-5-Mononitrat und Acetylsalizylsäure (Platelet aggregation under SIN-1: Comparison with isosorbide-5-mononitrate and acetyl salicylic acid). Z. Kardiol.(Supp 5):9-11

86.     Frey A, Haider M, Rösch R, Rösch A, Drummer C,Gerzer R, Theisen K (1991) Thrombozytenfunktion bei instabiler Angina pectoris nach parenteraler Gabe von Nitroglycerin und von Molsidomin (Platelet function in unstable angina pectoris after parenteral treatment with nitroglycerine and molsidomine). Z. Kardiol.(Supp 5):55-57

87.       Heidemann F, Steinke W, Pleiss U, Theiss G, Voges K-P, Kazda S,Gerzer R, Stasch J-P (1991)  Autoradiographic localization of 125I-C-ANF compared to 125I-ANF in rat tissue.Histochemistry 96:317-321

88.       Röcker L, Sander MM, Molz A-B, Heyduck B, Gunga H-C,Gerzer R, Weil J, Drummer C (1991) Die circadiane Rhythmik der Plasma-Volumen-regulierenden Hormone (Renin, Aldosteron, ADH           und ANF) unter Berücksichtigung weiterer Blutparameter (Cortisol, cGMP, Plasmavolumen, Plasmaproteine und Elektrolyte) (Circadian rhythm of plasma volume regulating hormones (renin, aldosterone and AFH) with respect to further blood parameters (cortisol, cGMP, plasma volume, plasma proteins and electrolytes) in:DARA-Symposium 1991 Forschung unter Weltraumbedingungen, 371-376

89.       Drummer C, Lüdke S, Spannagl M, Schramm W,Gerzer R(1991) The nitric oxide donor SIN-1 is a potent inhibitor of plasminogen activator inhibitor release from stimulated platelets.Thromb. Res.63:553-556

90.       Singh S, Singh G, Heim J-M,Gerzer R(1991) Isolation of a guanylate cyclase-coupled heat   stable enterotoxin receptor cDNA from a human colonic cell line.Biochem. Biophys. Res.  Commun.179:1455-1463

91.       Spes C, Angermann C,Gerzer R, Dominiak P, Weil J, Beyer RW, Kemkes BM, Theisen K (1991) Plasma hormones in patients with chronic heart failure before and early after orthotopic heart    transplantation.Z. Kardiol.80:580-584

92.      Gerzer R, Drummer C, Weil J, Lang R, Stromeyer H (1991) Regulation of volume homeostasis in reduced gravity: Possible involvement of atrial natriuretic factor, urodilatin and cyclic GMP. in:  Research Program of the German Spacelab Mission D-2, Sahm PR, Keller MH, Schiewe B         (Eds):51-54

93.       Kentsch M, Drummer C, Müller-Esch G,Gerzer R(1991) Urodilatin – Klinische Bedeutung des    renalen natriuretischen Peptids (Urodilatin – clinical importance of the renal natriuretic peptide). Dtsch. med. Wochenschr.116:1405-1411

94.       Stangl K, Baumann G,Gerzer R, Weil J (1991) Acute effects of beta-adrenergic stimulation with  dobutamine on the plasma levels of atrial natriuretic peptide and cyclic guanosine monophosphate in patients with chronic heart failure.Eur. Heart J.12:917-923

1992

95.       Heim J-M, Singh S, Fülle H-J,Gerzer R(1992) Comparison of a cloned ANF-sensitive guanylate cyclase with guanylate cyclase from adrenal cortex.Naunyn Schmiedeberg’s Arch. Pharmacol.345:64-70

96.      Gerzer R(1992) Klinische Bedeutung des intrazellulären Botenstoffs zyklisches Guanosinmonophosphat (Clinical importance of the intracellular messenger cyclic Guanosine monophosphate). Einsichten – Forschungszeitschrift der LMU München31-33

97.       Angermann CE, Spes CH, Dominiak P, Weil J,Gerzer R, Stempfle H-U, Kemkes BM, Theisen K  (1992) Effects of graded exercise on blood pressure, heart rate and plasma hormones in cardiac        transplant recipients before and during antihypertensive therapy.Clin. Investig.70:14-21

98.       Drummer C, Heer M, Baisch F, Blomqvist G, Lang RE, Maaß HP,Gerzer R(1992) Diuresis and             natriuresis following isotonic saline infusion in healthy young volunteers before, during, and after head-down tilt.Acta Physiol.Scand.144 (S 604):101-111

99.       Heer M, Drummer C, Baisch F, Maass H,Gerzer R, Kropp J, Blomqvist G (1992) Effects of head         down tilt and saline loading on body weight, fluid and electrolyte homeostasis in man.Acta Physiol. Scand.144(S 604):13-22

100.      Emmeluth C, Drummer C,Gerzer R, Bie P (1992) Role of cephalic Na+ concentration and  urodilatin in the regulation of renal Na+ excretion.Amer. J. Physiol.262:F513-F516

101.      Lauster F, Fülle H-J,Gerzer R, Schiffl H (1992) The postdialytic plasma cyclic GMP level as a   measure of fluid overload in chronic haemodialysis.J. Amer. Soc. Nephrol.2:1451-1454

102.      Kentsch M, Ludwig D, Drummer C,Gerzer R, Müller-Esch G (1992) Hemodynamic and renal effects of urodilatin in healthy volunteers.Eur. J. Clin. Invest.22:319-325

103.      Drummer C,Gerzer R, Heer M, Molz B, Bie P, Schloßberger M, Stadaeger C, Röcker L, Strollo F, Heyduck B, Bauer K, Warberg J, Baisch F, Christensen N-J, König A, Norsk P (1992) Effects of an acute saline infusion on fluid and electrolyte metabolism in humans.Amer. J. Physiol.   262:F744-F754

104.      Brundobler M, Horn M,Gerzer R, Mönch V, Vetter C, Meierhofer N, Hartinger A, Birkner B (1992) Aminoglykosidtherapie bei Intensivpatienten: Was ist die optimale Strategie? (Aminoglycoside therapy in intensive care patients: What is the optimal strategy?) Intensivmedizin29:219-226

105.     Gerzer R, Drummer C (1992) Hormonal control of body fluid metabolism.Acta Astronautica   27:109-114

106.      Kentsch M, Lawrenz R, Ball P,Gerzer R, Müller-Esch G (1992) Effects of atrial natriuretic factor on anterior pituitary hormone secretion in normal subjects.Clin. Investig.70:549-555

107.      Kentsch M, Ludwig D, Drummer C,Gerzer R, Müller-Esch G (1992) Hemodynamic and renal effects of urodilatin bolus injections in patients with congestive heart failure. Eur. J. Clin. Invest.   22:662-669

108.     Gerzer R, Drummer C, Ivanova K, Luedke S, Spannagl M, Schaefer M, Karrenbrock B, Heim J- M, Schramm W (1992) Determination of the anticoagulatory properties of nitric oxide-liberating drugs in clinical studies.Proc. 2nd Int.Congress on nitric oxide, London 353-355

1993

109.      Ivanova K, Schaefer M, Drummer C,Gerzer R(1993) Effects of NO-containing compounds on increases in cytosolic ionized calcium and on aggregation of human platelets.Eur. J. Pharmacol.244:37-47

110.      Wehling M, Christ M,Gerzer R(1993) Aldosterone-specific membrane receptors and related rapid, non-genomic effects.Trends Pharmacol. Sci.14:1-4

111.      Kuhn M, Raida M, Adermann K, Schulz-Knappe P,Gerzer R, Heim J-M, Forssmann W-G (1993) The circulating bioactive form of human guanylin is a high molecular weight peptide (10.3 kD).  FEBS Lett.318:205-209

112.      Endres S, Fülle H-J, Sinha B, Stoll D,Gerzer R(1993) Regulation of cytokine synthesis through cyclic nucleotides.In: Host defense dysfunction in Trauma, Shock and Sepsis(ed. Faist,   Meakins, Schildberg) 609-612

113.      Menshikov MY, Ivanova K, Schaefer M, Drummer C,Gerzer R(1993) Influence of the cGMP analog 8-PCPT-cGMP on agonist-induced aggregatory and calcium responses of human  platelets.Eur. J. Pharmacol.245:281-284

114.      Drummer C, Fiedler F, Bub A, Kleefeld D, Dimitriadis E,Gerzer R, Forssmann W-G (1993)  Development and application of a urodilatin (CDD/ANP 95-126)-specific radioimmunoassay.Eur.  J. Physiol.423:372-377

115.      Lauster F, Drummer C,Gerzer R, Schiffl H (1993) Plasma ANP and cGMP in CAPD patients.   Contribut Nephrol101:44-50

116.     Gerzer R, Drummer C (1993) Is the renal natriuretic peptide urodilatin involved in the regulation of natriuresis?J Cardiovasc Pharmacol.22:S86-S87 (Supp 2)

117.      Lauster F, Heim J-M, Drummer C, Fülle H-J,Gerzer R, Schiffl H (1993) The plasma cGMP level as determinant of the hydration state in renal replacement therapy.Kidney International43  suppl. 41:S57-S59

118.      Norsk P, Johansen LB, Drummer C,Gerzer R(1993) Effect of water immersion on renal    natriuretic peptide excretion (urodilatin, ANP 95-126) in humans.J. Appl. Physiol.74:2881-2885

119.      Drummer C, Heer M, Dressendörfer RA, Strasburger CJ,Gerzer R(1993) Consistently reduced natriuresis during weightlessness.Clin. Invest.71:678-686

120.      Heer M, Drummer C, Maass H, Röcker L, Baisch F,Gerzer R(1993) Long-term elevations of  dietary sodium produce parallel increases in the renal excretion of urodilatin and sodium.Eur. J. Physiol.425:390-394

 1994

121.      Buechler W, Ivanova K, Wolfram G, Drummer C, Heim J-M,Gerzer R(1994) Soluble guanylyl cyclase and platelet function.Annals N.Y. Acad. Sci. Vol 714 (ed: GA Fitzgerald, LK Jennings, C Patrono)

122.      Emmeluth C, Drummer C,Gerzer R(1994) Natriuresis in conscious dogs caused by increased carotid (Na+) during angiotensin II and aldosterone blockade.Acta Physiol. Scand.151:403-411

123.      Krause G, David S, Wehling M,Gerzer R(1994) Distinction of weakly homologous cDNA amplificates by single-strand conformation polymorphism analysis: Application to guanylyl cyclase isozymes.Electrophoresis15:557-561

124.      Heim J-M, Montigel U,Gerzer R(1994) ANF-sensitive guanylyl cyclase activity in rat liver tissues flown on SLS-1.Proc. 5th Eur. Symp. on Life Sci. Res. in Space, Arcachon, France: 35-36

125.     Gerzer R, Drummer C, Heer M (1994) Antinatriuretic kidney response to weightlessness. Acta Astronautica 33:97-100

126.      Krause G, Heim J-M, Bayerl A, Singh S,Gerzer R(1994) Distribution of membrane-bound guanylyl cyclases in human intestine.GUT35:1250-1257

127.      Nakamitsu S, Sagawa S, Miki K, Wada F, Nagaya K, Keil LC, Drummer C,Gerzer R, Greenleaf JE, Hong SK, Shiraki K (1994) Effect of water temperature on diuresis: AVP, ANP and Urodilatin during immersion in men.J. Appl. Physiol.77:1915-1925

128.      Epstein M,Gerzer R(1994) Natriuretic peptides and the kidney.Textbook of Nephrology;ed. S.G. Massry, R.J. Glassock; Williams and Wilkins 3rd Edition:227-231

129.      Hönicka M, David S, Spahr R, Feelisch M,Gerzer R(1994) Characterization of the glyceryl  trinitrate-converting activity of isolated bovine aorta microsomes. in: Moncada, Feelisch, Busse, Hicks (eds):The Biology of Nitric OxideIV: Enzymology, Biochemistry and Immunology. Portland Press, London 248-251

 1995

130.      Kentsch M, Drummer C,Gerzer R, Müller-Esch G (1995) Severe hypotension and bradycardia   after intravenous urodilatin infusion in patients with congestive heart failure.Eur J Clin Invest    25:281-283

131.      Norsk P, Drummer C, Röcker L, Strollo F, Christensen NJ, Warberg J, Bie P, Stadeager C,       Johansen LB, Heer M, Gunga H-C,Gerzer R(1995) Renal and endocrine responses in humans  to an isotonic saline infusion during microgravity.J. Appl. Physiol.78:2253-2259

132.      Buechler WA, Singh S, Aktas J, Müller S, Murad F,Gerzer R(1995) High level expression of    biologically active soluble guanylyl cyclase using the baculovirus system is strongly heme-dependent in:Adv. Pharmacol: Nitric Oxide; Academic Press ed.:L. Ignarro, F Murad

133.      Padeken D, Sotiriou D, Boddy K,Gerzer R(1995) Health care in remote areasJ. Med. Systems 19:63-70

134.      Kentsch M, Otter W, Drummer C, Peinke V, Theisen K, Müller-Esch G,Gerzer R(1995) The dihydropyridine calcium channel blocker BAY t 7207 attenuates the exercise induced increase of plasma ANF and cyclic GMP in mild congestive heart failure.Eur. J. Clin. Pharmacol.49: 177-        182

135.      Dressendörfer R, Heim J-M,Gerzer R, Strasburger C (1995) A non-isotopic immunoassay for   guanosine 3´:5´-cyclic monophosphate using a cyclic GMP-biotin conjugate as tracer.J.  Immunoassay16:37-53

136.      Meyer zum Gottesberge AM, Schleicher A, Drummer C,Gerzer R(1995) The volume protective natriuretic peptide system in the inner ear.Acta Otolaryngol.Suppl 520:170-173

1996

137.      Wolfram G, Meier U, Scheske U, Horn M, Drummer C, Spannagl M,Gerzer R(1996) Effect of   organic nitrates on ex vivo platelet aggregation and fibrinolysis in manEur. J. Med. Res.1:1-8

138.      Drummer C, Frank W, Heer M, Forssmann WG,Gerzer R, Goetz KL (1996) Postprandial  natriuresis in humans: further evidence that urodilatin, not ANP, modulates sodium excretion.Amer. J. Physiol.270: F301-F310

139.      Emmeluth C, Goetz KL, Drummer C,Gerzer R, Forssmann WG, Bie P (1996) Natriuresis caused by increased carotid (Na+) after renal denervation.Amer. J. Physiol.270:F510-F517

140.      Wolfram G, Sitter T, Gottsmann M,Gerzer R, Schiffl H (1996) Assessment of dry weight in hemodialysis patients by the volume markers ANP and cGMP. Nephrol. Dial. Transplant.    11(Supp2): 28-30

141.      Heim J-M, Singh S, Krause G,Gerzer R(1996) Effect of glycosylation on cloned ANP-sensitive guanylyl cyclaseLife Sciences59: 61-68

142.     Gerzer R, Heer M, Drummer C (1996) An overview of body fluid metabolism at actual and simulated microgravity.Proc. Med. Sci. in Sports and Exercise 28:S32-S35

143.      Padeken D,Gerzer R, Arbter K, Feußner H (1996) Telemedizin – Online Sprechstunde via  Satellit (Telemedicine – online consultation by satellite). Flug- und Reisemedizin3:4-6

144.      Heim J-M, Knau B, Sturm C, Fricke H, Hartmann J, Pachmann K, Schmidt K-N, Vollmar A,  Gerzer R(1996) Particulate ANP-sensitive guanylyl cyclase: induction in cultured human peripheral CD3+ mononuclear blood cells.J. Mol. Med. 74:629-635

145.      Riepl R, Drummer C, Reichhardt B, Lehnert P,Gerzer R(1996) Short-term and long-term influence of microgravity on plasma levels of gastroenteropancreatic peptides.ESA-Proceedings EURO-MIR 94,ESA SP-390:235-239

146.      Zange J, Müller K,Gerzer R, Wehling M (1996) Non-genomic effects of aldosterone on phosphocreatine levels in human calf muscle during recovery from exercise.J. Clin. Endocrin. Metab.81:4296-4300

147.      Kentsch M, Drummer C, Nötges A,Gerzer R, Müller-Esch G (1996) Neutral endopeptidase 24.11 may not exhibit beneficial hemodynamic effects in patients with congestive heart failure.Eur. J. Clin. Pharmacol.51:269-272

 1997

148.      Knau B, Sturm C, Heim J-M, Fricke H, Emmerich B, Haas RJ,Gerzer R(1997) Particulate ANP- sensitive guanylyl cyclase in blood and bone marrow cells of patients with acute leucemiaEur. J. Med. Res.2: 101-105

149.      Hönicka M,Gerzer R(1997) Lösliche Guanylatzyklasen: Schlüsselenzyme zum therapeutischen Einsatz des Prinzips NO (Soluble guanylate cyclases: Key enzymes for the therapeutic application of the principle NO). Internist38:427-437

150.      Drummer C, Heer M, Herten M,Gerzer R(1997) Regulation of volume homeostasis in reduced gravity: Possible involvement of atrial natriuretic peptide, renal natriuretic peptide and cyclic     GMP.in: ESA SP-1191: Anthrorack on the Spacelab D2 Mission  71-76

151.      Norsk P, Stadeager C, Johansen LB, Christensen NJ, Warberg J, Bie P, Drummer C, Heer M, Gerzer R, Röcker L, Gunga HC, Strollo F (1997)in: ESA SP-1191: Anthrorack on the  Spacelab D2 Mission

152.      Drummer C, Kentsch M, Otter W, Heer M, Herten M,Gerzer R(1998) Increased renal natriuretic peptide (Urodilatin) excretion in heart failure patients.Eur. J. Med. Res.2:347-354

153.      Krause G, Meyer zum Gottesberge A, Wolfram G,Gerzer R(1997) Transcripts encoding three types of guanylyl cyclase-coupled trans-membrane receptors in inner ear tissues of guinea pigs. Hearing Res.110:95-106

154.      Krause G, Oduncu F, Kaltstein A, Pusl T, Pachmann K,Gerzer R(1997) Applications of consensus polymerase chain reaction with subsequent electrophoretic distinction of amplificates.  Electrophoresis18:1098-1102

155.      Padeken D, Weber T,Gerzer R(1997) Telemedizin: ein Beitrag zum Re-engineering des Gesundheitswesens (Telemedicine – a contribution to the re-engineering of the health system). DLR-Jahresbericht 1996/1997:18-21

156.      Ivanova K, Le Poole C,Gerzer R, Westerhof W, Das PK (1997) Effects of nitric oxide on the  adhesion of human melanocytes to extracellular matrix components.J. Pathol.183:469-476

 1998

157.      Kentsch M, Kuhrmann T, Drummer C, Rodemerk U,Gerzer R, Müller-Esch G (1998) Die renale  Urodilatin-Sekretion ist mit der Diurese und Natriurese nach spontanen, supraventrikulären   Tachykardien assoziiert (Renal urodilatin secretion is associated with diuresis and natriuresis after spontaneous supraventricular tachycardias). Z. Kardiol. 87:134-138

158.      Wenzel J, Luks N, Plath G, Wilke D, Gerzer R(1998) The influence of CO2 in a space-like environment: study design.Aviat. Space and Envir. Med. 69:285-290

159.      Sexton J, Mueller K, Elliott A, Gerzer R, Strohl KP (1998) Low level CO2 effects on pulmonary function in humans.Aviat. Space and Envir. Med. 69:387-390

160.      Wenzel J, Samel A, Manzey D,Gerzer R(1998) Physiologische Regulation von circadianen Rhythmen (Physiological regulation of circadian rhythms). in: Handbuch für Arbeitsmedizin, ECO-Med Verlag ed: Konietzko

161.      Samel A,Gerzer R,Wenzel J, Manzey D (1998) Zirkadiane Rhythmen bei Zeitzonenflügen (Circadian rhythms in time zone flights). in: Handbuch für Arbeitsmedizin, ECO-Med Verlag ed: Konietzko

162.      Manzey D,Gerzer R, Samel A, Wenzel J (1998) Psychologische Aspekte zirkadianer Rhythmik (Psychological aspects of circadian rhythms). in:Handbuch für Arbeitsmedizin, ECO-Med Verlag ed: Konietzko

163.     Gerzer R, Heim J-M, Manzey D, Wenzel J, Samel A (1998) Rhythmusgeber von zirkadianen Rhythmen (Regulation of circadian rhythms). in: Handbuch für Arbeitsmedizin, ECO-Med Verlag ed: Konietzko

164.      Herten M, Lenz W,Gerzer R, Drummer C (1998) The renal natriuretic peptide urodilatin is present in human kidney.Nephrol Dial Transplant13:2529-2535

165.     Gerzer R(1998) Aufgaben und Möglichkeiten der Klinischen Pharmakologie im Bereich der Großforschungseinrichtungen (Challenges and opportunities of clinical pharmacology in major research establishments). in: Klinische Pharmakologie17: Aufgaben und Möglichkeiten der Klinischen Pharmakologie, Zuckschwerdt-Verlag München ed: M. Wehling pp. 53-61

 1999

166.      Hoenicka M, Becker EM, Schroeder H, Apeler H, Sirichoke T,Gerzer R,Stasch JP (1999) Purification and characterization of a heme-containing and nitric oxide-stimulated soluble guanylyl cyclase expressed in a baculovirus/SF9 system.J Mol Med77:14-23

167.      Lenz W, Herten M,Gerzer R, Drummer C (1999) Regulation of natriuretic peptide (urodilatin) release in a human kidney cell line.Kidney Internat. 55:91-99

168.      Becker EM, Wunder F, Kast R, Robyr C,Hoenicka M,Gerzer R, Schröder H, Stasch J-P (1999)  Generation and characterization of a stable soluble guanylyl cyclase overexpressing CHO cell lineNitric oxide: Biology and Chemistry3:55-66

169.      Lang SM, Wolfram G,Gerzer R, Schiffl H (1999) Characterization of subtypes of hypertension in CAPD patients by cyclic guanosine monophosphate Peritoneal Dialysis International19:143-147

170.        Gerzer R(1999) Leben mit und ohne Schwerkraft (Living with and without gravity).DLR-Nachrichten94:26-31

171.        Gerzer R(1999) Medicine and Mobility: Challenge for the next Century.Eur. J. Med. Res. 4:349- 352

172.     Wilke D, Padeken D, Weber T,Gerzer R(1999) Telemedicine for the International Space Station. Acta Astronautica44: 579-581

173.      Sitter T, Holzgartner V, Wolfram G, Toepfer M, Klare B,Gerzer R, Schiffl H (1999) Assessment of hypervolemia by cyclic 3´,5´-guanosine monophosphate (cGMP) in pedriatric patients on   hemodialysis Nephron83:287-288

2000

174.      Becker EM, Schmidt P, Schröder H, Walter U, Hoenicka M,Gerzer R, Stasch J-P (2000) The vasodilator-stimulated phosphoprotein (VASP): mediator of YC-1 and NO effects in human and rat platelets. J. Cardiovasc. Pharmacol. 35:390-397

175.      Farack UM, Asher A, Elsenhans B, Schütte-Lückenga B,Gerzer R(2000) Effect of loperamide on mucosal guanylyl cyclase activity in rat jejunum following Escherichia coli heat-stable toxin-induced fluid accumulation. Pharmacology and Toxicology 86:78-82

176.      Heer M, Baisch F, Kropp J,Gerzer R,Drummer C (2000) High dietary sodium chloride consumption may not induce body fluid retention in humans.Amer. J. Physiol. 278:F585-F595

177.     Gerzer R(2000) Der Paradigmenwechsel in der Medizin hat bereits begonnen (The paradigm change in medicine has already started). Editorial Gastronachrichten 29:2-3

178.     Gerzer R, Weyer H (2000) Auf dem Weg zum leisen Flugzeug (Towards silent aeroplanes). Eingeladene Übersicht.  Frankfurter Allgemeine Zeitung 6.6.2000

179.     Gerzer R,Beck L (2000) Perspektiven für den Einsatz von Telemedizin in der Reisemedizin (I) (Perspectives for the use of telemedicine in travel medicine) Vortragssammelband 1. Forum Reisen und Gesundheit ITB 2000:23-28

180.     Gerzer R(2000) Spin on: Raumfahrtmedizin als Beispiel zukunftsfähiger Forschung (Space Medicine as an example of research for the future). Bilanzsymposium Forschung unter Weltraumbedingungen; ed: MH Keller, PR Sahm 687-697

181.      Riepl RL, Drummer C, Reichardt B, Lehnert P,Gerzer R(2000) Einfluß der Schwerelosigkeit auf die Plasmaspiegel von gastroenteropankreatischen Peptiden (Influence of weightlessness on the plasma levels of the gastroenteropancreatic peptide peptidin). Bilanzsymposium Forschung unter Weltraumbedingungen; ed: MH Keller  PR Sahm 773-776

182.     Gerzer R, Ruyters G (2000) Integrated Physiology in Space – Challenges for the Future: The Bad Honnef Recommendations (Editorial) Eur J Physiol. 441:R5-R7.

183.      Drummer C,Gerzer R, Baisch F, Heer M (2000) Body fluid regulation in µ-gravity differs from earth – an overview. Eur J Physiol. 441:R66-R72

184.      Ewald R, Lohn K,Gerzer R(2000) The Space Mission MIR´97: Operational Aspects.Eur. J. Clin. Invest.30:1027-1033

185.      Drummer C, Hesse C, Baisch F, Norsk P, Elmann-Larsen B,Gerzer R, Heer M (2000) Water- and Sodium Balances and their Relation to Body Mass Changes in MicrogravityEur. J. Clin.  Invest.30:1066-1075

2001

186.      Ivanova K, Das PK, van den Wijngaard RMJGJ, Lenz W, Klockenbring T, Malcharzyk V, Drummer C,Gerzer R(2001) Differential expression of functional guanylyl cyclases in melanocytes: Absence of nitric oxide-sensitive isoform in metastatic cellsJ. Investig. Dermatol. 116:409-416

187.      Stasch JP, Becker EM, Alonso-Alija C, Apeler H, Dembowsky K, Feurer A,Gerzer R, Minuth T, Perzborn E, Pleiß U, Schröder H, Schröder W, Stahl E, Steinke W, Straub A, Schramm M (2001) NO-independent regulatory site on soluble guanylate cyclase.Nature(Letter) 410:212-215

188.     Gerzer R(2001) Raumfahrtmedizin (Space Medicine). Astronomie und Raumfahrt im Unterricht 62:30-32

189. Gerzer R, Heer M, Baisch F (2001) Anpassung des Menschen an Schwerelosigkeit: Flüssigkeitshaushalt (Adaptation of humans to weightlessness). In:Mensch – Leben – Schwerkraft – Kosmos. Perspektiven biowissenschaftlicher Weltraumforschung in Deutschland. Verlag Günter Heimbach, Stuttgart; ed: H. Rahmann, KA Kirsch. 230 – 239

190.      Horneck G, Facius R, Reitz G, Rettberg P, Baumstark-Khan C,Gerzer R(2001) Critical issues in connection with human planetary missions: Protection of and from the environment. Acta Astronautica49: 279-288

191.     Christ M, Zange J, Janson CP, Müller K,. Kuklinski P, Schmidt BMW, TillmannHC, Gerzer R, Wehling M, MD (2001) Hypoxia modulates rapid effects of aldosterone on oxidative metabolism in human calf muscle.J. Endocrinol. Invest.24: 587-597

192.      Becker EM, Alonso-Alija C, Apeler H, Gerzer R, Minuth T, Pleisz U, Schmidt P, Schramm M, Schröder H, Schröder W, Steinke W, Straub A, Stasch J-P (2001) NO-independent regulatory site of direct sGC stimulators like YC-1 and BAY 41-2272;BMC Pharmacology1:13

 2002

193. Riepl R, Drummer C, Lehnert P,Gerzer R, Otto B (2002) Influence of microgravity on plasma levels of gastroenteropancreatic peptides: A case study.Aviat. Space Envir. Med. 73:206-210

194.     Gerzer R(2002) Weltraummedizin (Space Medicine). Berliner Ärzteblatt115:393-394

195.      Nickelsen T, Samel A, Vejvoda M, Wenzel J, Smith B,Gerzer R(2002) Chronobiotic effects of the melatonin agonist LY 156735 following a simulated 9-hour time shift: Results of a placebo-controlled trial.Chronobiology International.19: 915-936

196. Kamps N,Gerzer R, Heer M (2002) Effects of L-arginine supplementation on bone metabolism. J.Grav. Physiol.9:P-179

197.      Ivanova K, Hamidi Zadeh N, Block I, Das PK,Gerzer R(2002) Gravity and cyclic GMP levels in melanocytic cells. J. Grav. Physiol.9: P-271

 2003

198.      Baecker N, Tomic A, Mika C, Gotzmann A, Platen P,Gerzer R, Heer M (2003) Bone resorption is induced on the second day of bed rest: results of a controlled crossover trial. J Appl Physiol.95:977-82

199.      Horneck G, Facius R, Reichert M, Rettberg P, Seboldt W, Manzey D, Comet B, Maillet A, Presii H, Schauer L, Dussap CG, Poughon L, Belyavin A, Reitz G, Baumstark-Khan C,Gerzer R(2003) humex: a study on the survivability and adaptation of humans to long-duration exploratory missions. Part I, Lunar Missions, Adv. Space Res31:2389-2401

200.      Horneck G, Facius R, Reitz G, Rettberg P, Baumstark-Khan C,Gerzer R(2003) Critical issues in connection with human missions to Mars: protection of and from the Martian environment. Adv Space Res. 2003;31(1):87-95

201.      Lindlar M, Thömmes A, Koch B, Weber T, Poddig D, Meier M, Schuber M,Gerzer R(2003) Using telemedicine to deliver medical expertise to the German forces in foreign deployment. In: 2. Eurpoäischer Kongress Forteschritt der Raumfahrtmedizin für die gesundheitliche und industrielle Praxis.Pabst Publishers LengerichISBN 3-89967-084-1; S. 63 – 70

2004

202.      Baisch FJ,Gerzer R(2004) Positive pressure breathing by total body negative pressure: a new simulation model for fluid balance in weightlessness.Acta Astronaut. 54: 649-655

203.      Mortimer AJ, DeBakey ME,Gerzer R, Hansen R, Sutton J, Neiman SN (2004) Life science research in space brings health on earth. Acta Astronaut.54: 805-812

204.      Ivanova K, Hamidi N, Block I, Das PD,Gerzer R(2004) Stimulation of cyclic GMP efflux in human melanocytes by hypergravity generated by centrifugal acceleration.Pigment Cell Res. 17: 471-479

2005

205.      Baecker N, Boese A, Schoenau E,Gerzer R, Heer M (2005) L-arginine, the natural precursor of nitric oxide, is not effective for preventing bone loss in postmenopausal women.Journal of Bone and Mineral Research20:471-479

206.     Gerzer R (2005) Was bringt uns die Weltraummedizin? Beispiele aus der Grundlagenforschung (What is Space Medicine for? Examples from basic research) MedReport 11:4-5

207.      Ivanova, K, van den Wijngaard, RMJGJ,Gerzer, R,Lamers, WH, Das, PK (2005) Non-lesional vitiligous melanocytes are not characterized by an increase proneness to nitric oxide-induced apoptosis.Exp Dermatol 14:445-453

208.      Gerzer R, Küpper T, Mika C, Rieke B, Flach E, Weber T, Poddig D, Lindlar M, Matsakis Y,       Sachdev K, Kumar V, Sachdev A, Orlov O, Russomano T, Sparenberg A, Kröger E (2005)      Zukunftsvision oder bald Realität? Telemedizinische Betreuung von Reisenden (Vision only or reality soon? Telemedical care of travelers)     Reisemedizinisches Symposium, ITB Berlin, Tagungsband

209.     Gerzer R, Heer M (2005) Regulation of body fluid and salt homeostasis – from observations in space to new concepts on earth.Curr. Pharmaceut. Biotechnol. 6:299-304

210.         Heer M, Baecker N, Mika C, Boese A,Gerzer R(2005) Immobilization induces a very rapid increase in osteoclast activity. Acta Astronaut. 57:31-36

211.      Gerzer R, Hemmersbach R, Horneck G (2005) Life Sciences in:Utilization of Spaceeds: Feuerbacher B, Stoewer H; Springer Verlag 341-373

212.      Stieber C, Ivanova C, Block I,Gerzer R(2005) Hypergravity modulates cyclic GMP efflux in nitric oxide-stimulated human melanocytic cells.J. Grav. Phys.12: P251-252

213.      Ivanova K, Lambers B, Block I, Bromeis B, Das PK, Gerzer R (2005) Molecular mechanisms of gravity-dependent singnaling in human melanocytic cells involve cyclic GMP.J. Grav. Phys. 12: P237-238

 2006

214.      Küpper T, Mika C, Ebel K, Lindlar M,Gerzer R(2006) TEMOS: Krankenhäuser im Ausland (TEMOS: Hospitals abroad). Flug- und Reisemedizin13:9-10

215.         Gerzer R, Koch B (2006) Über komplexe Studien und die Zukunft (On complex studies and future). DLR-Nachrichten113:5-11

216.     Gerzer R(2006) Verkehrsunfälle: Unterschätztes Risiko auf Reisen (Traffic accidents: Underestimated risk of travelers). Flug- und Reisemedizin 13:19-22

217.     Horneck G, Facius R, Reichert M, Rettberg P, Seboldt W, Manzey D, Comet B, Maillet A, Preiss H, Schauer L, Dussap CG, Poughon L, Belyavin A, Reitz G, Baumstark-Khan C,Gerzer R(2006)        HUMEX, a Study on the Survivability and Adaptation of Humans to Long-Duration Exploratory   Missions, Part II: Missions to Mars.Adv.Space Res. 38:752-759

218. Ivanova K, Block I, Das PK,Gerzer R(2006) Role of cyclic GMP signaling in melanocyte response to hypergravity. Signal Transduction 6: 406-413

 2007

219. Hinghofer H, Gerzer R(2007) The 15th IAA Humans in Space Symposium in Graz, Austria. Editorial,Acta Astronautica 60:221-222

220. Johannes B, Wittels P, Enne R, Eisinger G, Castro CA, Thomas JL, Adler AB, Gerzer R (2007) Non-linear function model of voice pitch dependency on physical and mental load. Eur. J. Appl. Physiol. 101:267-76

221.      Elmenhorst E-M, Gerzer R, Manzey D, Samel A, Wenzel J (2007) Zirkadiane Rhythmen (Circadian rhythms) in: Letzel S, Nowak D –Handbuch der Arbeitsmedizin BII-2.1, Ecomed-Verlag, 1-22

2008

222.   Gerzer R (2008) Human Flight to Mars: Challenges for Integrative Human Physiology, Gravit. Space Biol. 20:61-63

223. Zhuang F, Horneck G, Gerzer R (2008) The 16th IAA Humans in Space Symposium in Beijing, China. Editorial, Acta Astronautica 63: 695-696

224.    Klein K-E, Gerzer R (2008) Das Institut für Luft- und Raumfahrtmedizin des DLR: Über 70 Jahre im Dienste der Flugmedizin in: 60 Jahre Luft- und Raumfahrtmedizin in Deutschland nach 1945 (The Institute of Aerospace Medicine at DLR: Over 70 years in service of Aerospace Medicine in Germany after 1945) Ed: Wirth D, Harsch V Rethra-Verlag Neubrandenburg ISBN 978-3937394-10-7

225. Gerzer R (2008) Die Gesundheit von Astronauten und Piloten – Luft- und Raumfahrtmedizin im DLR (Health of Astronauts and pilots: Aerospace Medicine at DLR)– in: Deutsches Zentrum für Luft- und Raumfahrt – ein Portrait; ed: DLR, Köln 106-109

226. Ivanova K, Lambers B, van den Wijngaard R, Le Poole CI, Grigorieva O, Gerzer R, Das PK (2008) Immortalization of human melanocytes does not alter the de novo properties of nitric oxide to induce cell detachment from extracellular matrix components via cGMP. In Vitro Cellular & Developmental Biology; In Vitro Cell Dev Biol Anim. 44:385-95. Epub 2008 Jul 2

227. Koch B, Gerzer R (2008) A research facility for habitation questions to be built at the German Aerospace Center in Cologne: future challenges of Space medicine. Hippokratia 12 Suppl 1:91-96

228. Kluge G, Trammer M, Stern C, Gerzer R (2008) Kommerzieller suborbitaler Raumfahrttourismus. Vorschlag zur medizinischen Beratung (Commercial suborbital space tourism: Suggestions for medical care). Flugmedizin, Tropenmedizin, Reisemedizin 3:118-123

 2009

229. Melchor J. Antuñano, M.D. (USA),Rupert Gerzer, M.D. (Germany) (Chairs), Thais Russomano, M.D. (Brazil)(Secretary)in collaboration with Denise Baisden, M.D. (USA),Volker Damann, M.D. (Germany), Jeffrey Davis M.D. (USA), Gary Gray, M.D. (Canada), Anatoli Grigoriev, M.D. (Russia), Helmut Hinghofer-Szalkay, M.D. (Austria), Stephan Hobe, Ph.D. (Germany), Gerda Horneck, Ph.D. (Germany), Petra Illig, M.D. (USA), Richard Jennings, M.D. (USA), Smith Johnston, M.D. (USA), Nick Kanas, M.D. (USA), Chrysoula Kourtidou-Papadeli, M.D.  (Greece), Inessa Kozlovzkaya, M.D. (Russia), Jancy McPhee, Ph.D. (USA), William Paloski, Ph.D. (USA), Guillermo Salazar M.D. (USA), Victor Schneider, M.D. (USA), Paul Stoner M.D. (USA), James Vanderploeg, M.D. (USA), Joan Vernikos Ph.D. (USA-Greece), Ronald White, Ph.D. (USA), Richard Williams, M.D. (USA)“Medical Safety Considerations for Passengers on Short-Duration Commercial Orbital Space Flights”:International Academy of AstronauticsStudy Group Report ed:M. Antunano, S. Hobe,R. GerzerISBN/EAN 9782917761014; 28 pages

230. Kluge G,Gerzer R(2009) Eignungstests in der Flugmedizin (Tests in flight medicine). In: Check-up-Medizin. 213-218. ed: Uwe Nixdorff, Georg Thieme Verlag ISBN: 978-3-13-145271-9

231. Worms J-C, Lemmer H, Barucci A, Beebe R, Bibring J-P, Blamont J, Blanc M, Bonnet R, Brucato JR, Chassefière E, Coradini A, Crawford I, Ehrenfreund P, Falcke H,Gerzer R, Grady M, Grande M, Haerendel G, Horneck G, Koch B, Lobanov A, Lopez-Moreno JJ, Marco R, Norsk P, Rothery D, Swings J-P, Tropea C, Ulamec S, Westall F, Zarnecki J (2009)  ESSC-ESF Position Paper. Science-driven Scenario for Space Exploration: Report from the European Space Sciences Committee (ESSC). Astrobiology 9:23-41

232. Gerzer R (2009) Hypergravity and microgravity influence hemostasisEditorial Focus on: Effects of hypergravity and microgravity on platelet functions.Thrombosis and Hemostasis101:799

233.    Lindlar M, Mika C, Gerzer R (2009) TEMOS – Telemedical support for travellers and expatriates. In: Space Technologies for the Benefit of Human Society and Earth.   Ed: Phillip Olla, Madonna University, Livonia, Michigan, 554 p., Hardcover ISBN: 978-1-4020-9572-6; 179-200

 234.        Elmenhorst EM, Gerzer R (2009) Melanopsin-haltige Rezeptoren in der Retina modulieren den Schlaf (Melanopsin containing receptors in the retina modulate sleep). Flugmedizin, Tropenmedizin, Reisemedizin 16:116

2011

235.       Gerzer R(2011) Publishing VIDEO CLIPS in Acta Astronautica; Editorial,Acta Astronautica68: 651

236.       Gerzer R(2011)Private bemannte Raumfahrt: Beginn einer neuen Ära (Private human spaceflight: Begin of a new era) Editorial. Flugmedizin, Tropenmedizin, Reisemedizin18:159

237.        Kozlovskaya IB, Tomilovskaya ES, Gerzer R(2011) The 17th IAA Humans in Space Symposium 2009 in Moscow, Russia Acta Astronautica 68: 1417

238.   Hellweg CE,Gerzer R, Koch B, Boese A(2011) The Helmholtz Space Life Sciences ResearchSchool (SpaceLife): A new perspective in promotion of young researchers.Acta Astronautica68: 1620-1627

239. Gerzer R(2011) Are we alone? Editorial,Acta Astronautica68:1

 240.  Ivanova K, Eiermann P, Tsiockas W, Hauslage J, HemmersbachR, Gerzer R (2011) Natriuretic peptide-sensitive guanylyl cyclase expression is down-regulated in human melanoma cells at simulated weightlessness Acta Astronautica68: 652–655

241.   Gerzer R,Frings-Meuthen P (2011) Medizinische Forschung unter Weltraumbedingungen: Neudefinition der Regulation und Bedeutung des menschlichen Natriumhaushalts (Medical research under space conditions: New definition of regulation and importance of human sodium regulation). Flugmedizin, Tropenmedizin, Reisemedizin 18:70-73

242.    Gerzer R(2011) Weltraummedizin in neuem Licht (Space Medicine – new perspectives). LeitartikelDLR-Nachrichten

2012

243. Gerzer R(2012) Medizintourismus (Medicine tourism). In:Kursbuch Reisemedizin;T. Jelinek (ed) Thieme Verlag ISBN 978-3-13-150851-5; 241-247

244. Worms J-C, Walter N, White O, Martinez-Schmitt Johanne, Marshall-Bowman Karina, Blanc S, Monken I, Hockey B, Reitz G, Leys N, Mastroleo Felice, Comet B,Gerzer R, Horneck G (2012) Towards Human Exploration of Space: a EUropean Strategy – Roadmap. THESEUS Consortium (Indigo Strasbourg). ISBN 979-10-91477-00-0.

2013

245.  Rakova N, Jüttner K, Rauh M, Dahlmann A, Goller U, Beck L, Agureev  A, Vassilieva G, Lenkova L, Johannes B, Wabel P, Moissl U, Vienken J,Gerzer R, Eckardt K-U, Müller DN, Kirsch K, Morukov B, Luft FC, Titze J (2013) Mars500 flight simulations elucidate Na+ metabolism and balance in humans.Cell Metabolism17:125-131

246. Gerzer, R(2013) Weltraumtourismus (Space Tourism) in:Moderne ReisemedizinGentner-Verlag; ed.: Rieke B, Küpper T, Muth C-M ISBN 978-3-87247-754-5; pp 135-148

247. Eiermann P, Kopp S, Waßer K, Hemmersbach R,Gerzer R, Ivanova K (2013) Adaptation of a 2-D klinostat for simulated microgravity experiments with adherent cells.Microgravity – Science and TechnologyDOI 10.1007/s12217-013-9341-1

248. Rabbow, E, Koch B,Gerzer R(2013) :envihab: Neuartige Großforschungsanlage des DLR-Instituts für Luft- und Raumfahrtmedizin in Köln-Porz eröffnet (envihab: A new kind of major research facility of the DLR Institute of Aerospace Medicine opened in Cologne-Porz). Ort des Fortschritts: von der Idee bis zur Realisierung Flugmedizin – Tropenmedizin – Reisemedizin20: 188–193

249. Müller S, Quast T, Schröder A, Hucke S, Klotz L, Jantsch J,Gerzer R, Hemmersbach R, Kolanus W (2013) Salt-dependent chemotaxis of macrophagesPLoS ONE 8(9): e73439. doi:10.1371/journal.pone.0073439

250. Koch B, Wütscher F, Aeschbach D, Anken R, Maschke P, Reitz G, Rittweger J, Stern C,Gerzer R (2013) Gesundheit und Leistungsfähigkeit – Eine Kernaufgabe der wissenschaftlichen Forschungstätigkeit des Instituts für Luft- und Raumfahrtmedizin des DLR (Health and performance – Mayor research task of the DLR Institute of Aerospace Medicine). Wehrmedizinische Monatsschrift 57:242-247

251. Kluge G, Trammer M, Stern C, Chaudhuri-Hahn, I, Tuschy P,Gerzer R(2013) Commercial suborbital space tourism – Proposal on passenger medical selection.Acta Astronautica 92:187-192

2014

252. Meuer J,Gerzer R(2014) Mediziner als First-Responder an Bord von Verkehrsflugzeugen (Physicians as first responders on board of commercial airplanes). Flugmedizin, Tropenmedizin, Reisemedizin 21:116-119

253. Gerzer R(2014) Salt balance: From space experiments to revolutionizing new clinical concepts on earth – a historical review.Acta Astronautica104, 378-382

254. Gerzer R, White R, Graef P (2014) Space medicine and physiology in the exploration era: The Cologne resolution.Acta Astronautica 104:364

255. Antunano M,Gerzer R(2014) Medical Aspects of Suborbital Space Tourism. 53-61 In:Private human access to space Vol. 1: Suborbital flights. Ed: A. Buckley, W. Peeters. International Academy of Astronautics ISBN: 9782917761359

256. Orlov O, Sundblad P, Francisco D, Angerer O, Bareille M-P, Boese A, Cromwell R, Frings-Meuten P,Gerzer R, Godard B, Gräf P, Heer M, Iwase S, Kourtidou-Papadeli C, Kozlovskaya I, Larina I, Li Y, McPhee J, Meck J, Mukai C, Rittweger J (2014) Guidelines for standardization of bed rest studies in the spaceflight context. International Academy of Astronautics ISBN 9 782917 761342

2015

257. Gerzer R(2015) Space Medicine: Benefits for Medicine on Earth In: Medicine Update Vol. 25, 2015 ISBN: 978-81-9242260-5-1 Ed: R. Upadhyay, pp 1085-1087

258. Gerzer R(2015) Introduction to Space Medicine. API Textbook of Medicine, 10th Edition ISBN 978-93-5152-415-1 India, pp 2854-2860

259. Stingl JC, Welker S, Hartmann G, Damann V,Gerzer R(2015) Where failure is not an option –personalized medicine in astronauts.PLOSone 10: e0140764. doi:10.1371/journal.pone. 0140764

260. Gerzer R, Trammer M (2015) Flugmedizinische Aspekte der Raumfahrt (Flight medical aspects of human spaceflight). In: Moderne Flugmedizin, ed: T. Küpper and J. Siedenburg

261.  Hellweg CE, Spitta LF, Kopp K, Schmitz C, Reitz G, Gerzer R (2016) The Helmholtz Space Life Sciences Research School (SpaceLife): Two Generations of Doctoral Candidates. Advances in Space Research 57:378–397

262.  Gerzer R, Orlov O, Li Y-H, Mukai C, Graef P (2016) Space Physiology and Medicine in the Exploration Era: The IAA Virtual Institute of Space Life Sciences and Medicine. International Academy of Astronautics Cosmic Study, ISBN 978-2-917761-40-1; 21 pages

 

  • Life Sciences Award of the International Academy of Astronautics (2003)
  • Leonov Medal of the Association of Space Explorers (2013)
  • Gagarin Medal of the Russian Federation of Cosmonautics (2014)
  • Guest professorship at the Astronaut Center of China (2014)
  • Oleg Gazenko Memorial Medal of the Russian Society of Physiology (2016)
  •  Jean Henley Memorial Medal of the German Society of Anesthesiology and intensive care Medicine (2016)

At Skoltech, Prof Gerzer teaches a course on Human Spaceflight

including current and future spacecraft, space life sciences, space medicine and physiology, space tourism

ФИО: Руперт Герцер

Занимаемая должность (должности): Профессор, Заместитель Директора Космического Центра Сколтеха

Преподаваемые дисциплины: Космическая отрасль

Ученая степень: Доктор медицинских наук 1977, Университет Мюнхена

Ученое звание: нет

Наименование направления подготовки и/или специальности: Медицинские науки

Данные о повышении квалификации и/или профессиональной переподготовке: нет

Общий стаж работы: 38 лет

Стаж работы по специальности: 38 лет