Professor: Philipp Khaitovich
Pavel graduated from the Department of Bioengineering and Bioinformatics, Moscow State University, in 2008. He completed his postgraduate project at the Institute for Information Transmission Problems, Russian Academy of Sciences, and will be defending his thesis Age-Related Alternative Splicing Changes in Primate Brain in 2015. During his postgraduate studies Pavel worked at the Research Institute of Physical-Chemical Medicine (Moscow) and at the Partner Institute for Computational Biology (Shanghai). His research interests include development of software for RNA-seq data analysis, procaryotic and eucaryotic transcriptomics and, particularly, alternative splicing regulation. Pavel published several papers in peer-reviewed journals (Nucleic Acids Res. 2014. 42(21):13254-68; BMC Genomics. 2013. 14:72; Mol Syst Biol. 2013 Jan 22;9:633; Algorithms for Molecular Biology 2010, 5:29)
At Skoltech, Pavel is conducting research on identification of human biological features through high-throughput data analysis.
Evolution of developmental regulation of alternative splicing in mammals
Mazin PV, Jiang X, Fu N, Han D, Guo M, Gelfand MS, Khaitovich P. Conservation, evolution, and regulation of splicing during prefrontal cortex development in humans, chimpanzees, and macaques. RNA. 2018 Apr;24(4):585-596. doi: 10.1261/rna.064931.117. Epub 2018 Jan 23.
Mazin PV, Shagimardanova E, Kozlova O, Cherkasov A, Sutormin R, Stepanova VV, Stupnikov A, Logacheva M, Penin A, Sogame Y, Cornette R, Tokumoto S, Miyata Y, Kikawada T, Gelfand MS, Gusev O. Cooption of heat shock regulatory system for anhydrobiosis in the sleeping chironomid Polypedilum vanderplanki. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2477-E2486. doi: 10.1073/pnas.1719493115. Epub 2018 Feb 20.
Mazin, Pavel; Fisunov, Gleb; Gorbachev, Alexey; Kapitskaya, Kristina; Altukhov, Ilya; Semashko, Tatiana; Alexeev, Dmitry; Govorun, Vadim. Transcriptome analysis reveals novel regulatory mechanisms in a genome-reduced bacterium. Nucleic Acids Res. 2014. 42(21):13254-68.
Gorbachev A.Y., Fisunov G.Y., Izraelson M., Evsyutina D.V., Mazin P.V., Alexeev D.G., Pobeguts O.V., Gorshkova T.N., Kovalchuk S.I., Kamashev D.E., Govorun V.M. DNA repair in Mycoplasma gallisepticum // BMC Genomics. 2013. 14:726
Pavel Mazin, Jieyi Xiong, Xiling Liu, Zheng Yan, Xiaoyu Zhang, Mingshuang Li, Liu He, Mehmet Somel, Yuan Yuan, Yi-Ping Phoebe Chen, Na Li, Yuhui Hu, Ning Fu, Zhibin Ning, Rong Zeng, Hongyi Yang, Wei Chen, Mikhail Gelfand and Philipp Khaitovich. Widespread splicing changes in human brain development and aging. Mol Syst Biol. 2013 Jan 22;9:633.
Pavel V Mazin, Mikhail S Gelfand, Andrey A Mironov, Aleksandra B Rakhmaninova, Anatoly R Rubinov, Robert B Russell and Olga V Kalinina. An automated stochastic approach to the identification of the protein specificity determinants and functional subfamilies. Algorithms for Molecular Biology 2010, 5:29
Master of science in Biology. Diploma “Prediction of substrate specificity in protein families”, supervisor: O.V. Kalinina. Department of Bioengineering and Bioinformatics, Moscow State University, Moscow, Russia, 2008
Prediction of specificity determining positions in multiple protein alignments
Computational analysis of alternative splicing