pavelmazin

Pavel Mazin

Professor: Philipp Khaitovich

Pavel graduated from the Department of Bioengineering and Bioinformatics, Moscow State University, in 2008. He completed his PhD project at the Institute for Information Transmission Problems, Russian Academy of Sciences, and defended his thesis “Analysis of developmental alternative splicing changes in prefrontal cortex higher primates” in 2019.  During his postgraduate studies Pavel worked at the Research Institute of Physical-Chemical Medicine (Moscow) and at the Partner Institute for Computational Biology (Shanghai). His research interests include development of software for RNA-seq data analysis, procaryotic and eucaryotic transcriptomics and, particularly, alternative splicing regulation. Pavel published several papers in peer-reviewed journals (Nucleic Acids Res. 2014. 42(21):13254-68; BMC Genomics. 2013. 14:72; Mol Syst Biol. 2013 Jan 22;9:633; Algorithms for Molecular Biology 2010, 5:29)

At Skoltech, Pavel is conducting research on identification of human biological features through high-throughput data analysis.

  • Alternative splicing

  • Genomics

  • Transcriptomics

  • Human evolution

  • Brain development

  • LC-MS lipidomics

  • Genomics of agricultural plant and animals

  • Cardoso-Moreira M, Halbert J, Valloton D, Velten B, Chen C, Shao Y, Liechti A, Ascenção K, Rummel C, Ovchinnikova S, Mazin PV, Xenarios I, Harshman K, Mort M, Cooper DN, Sandi C, Soares MJ, Ferreira PG, Afonso S, Carneiro M, Turner JMA, VandeBerg JL, Fallahshahroudi A, Jensen P, Behr R, Lisgo S, Lindsay S, Khaitovich P, Huber W, Baker J, Anders S, Zhang YE, Kaessmann H. Gene expression across mammalian organ development. Nature. 2019 Jun 26. doi: 10.1038/s41586-019-1338-5.

  • SV Goryunova, DV Goryunov, AI Chernova, EU Martynova, AE Dmitriev, SV Boldyrev, AF Ayupova, PV Mazin, EA Gurchenko, AS Pavlova, DA Petrova, YV Chebanova, LA Gorlova, SV Garkusha, ZM Mukhina, EG Savenko, YN Demurin. Genetic and Phenotypic Diversity of the Sunflower Collection of the Pustovoit All-Russia Research Institute of Oil Crops (VNIIMK). Helia, doi.org/10.1515/helia-2018-0021

  • Chugunova A, Loseva E, Mazin P, Mitina A, Navalayeu T, Bilan D, Vishnyakova P, Marey M, Golovina A, Serebryakova M, Pletnev P, Rubtsova M, Mair W, Vanyushkina A, Khaitovich P, Belousov V, Vysokikh M, Sergiev P, Dontsova O. LINC00116 codes for a mitochondrial peptide linking respiration and lipid metabolism. Proc Natl Acad Sci U S A. 2019 Feb 22. pii: 201809105. doi: 10.1073/pnas.1809105116.

  • Chernova, Alina; Mazin, Pavel; Goryunova, Svetlana; Goryunov, Denis; Demurin, Yakov; Gorlova, Lyudmila; Vanyushkina, Anna; Mair, Waltraud; Anikanov, Nikolai; Yushina, Ekaterina; Ultra-performance liquid chromatography-mass spectrometry for precise fatty acid profiling of oilseed crops 2019 PeerJ, DOI: 10.7717/peerj.6547

  • Goryunov, Denis V; Anisimova, Irina N; Gavrilova, Vera A; Chernova, Alina I; Sotnikova, Evgeniia A; Martynova, Elena U; Boldyrev, Stepan V; Ayupova, Asiya F; Gubaev, Rim F; Mazin, Pavel V; Association Mapping of Fertility Restorer Gene for CMS PET1 in Sunflower Agronomy 9 2 49 2019 Multidisciplinary Digital Publishing Institute

  • Chernova, Alina; Gubaev, Rim; Mazin, Pavel; Goryunova, Svetlana; Demurin, Yakov; Gorlova, Lyudmila; Vanushkina, Anna; Mair, Waltraud; Anikanov, Nikolai; Martynova, Elena; UPLC–MS Triglyceride Profiling in Sunflower and Rapeseed Seeds Biomolecules 9 1 9 2019 Multidisciplinary Digital Publishing Institute

  • Funikov SY, Rezvykh AP, Mazin PV, Morozov AV, Maltsev AV, Chicheva MM, Vikhareva EA, Evgen’ev MB, Ustyugov AA. FUS(1-359) transgenic mice as a model of ALS: pathophysiological and molecular aspects of the proteinopathy. Neurogenetics. 2018 Aug;19(3):189-204. doi: 10.1007/s10048-018-0553-9. Epub 2018 Jul 7. PubMed PMID: 29982879.

  • Mazin PV, Jiang X, Fu N, Han D, Guo M, Gelfand MS, Khaitovich P. Conservation, evolution, and regulation of splicing during prefrontal cortex development in humans, chimpanzees, and macaques. RNA. 2018 Apr;24(4):585-596. doi:10.1261/rna.064931.117. Epub 2018 Jan 23. PubMed PMID: 29363555; PubMed Central PMCID: PMC5855957.

  • Mazin PV, Shagimardanova E, Kozlova O, Cherkasov A, Sutormin R, Stepanova VV, Stupnikov A, Logacheva M, Penin A, Sogame Y, Cornette R, Tokumoto S, Miyata Y, Kikawada T, Gelfand MS, Gusev O. Cooption of heat shock regulatory system for anhydrobiosis in the sleeping chironomid Polypedilum vanderplanki. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2477-E2486. doi: 10.1073/pnas.1719493115. Epub 2018 Feb 20. PubMed PMID: 29463761; PubMed Central PMCID: PMC5877948.

  • Mazin PV, Fisunov GY, Gorbachev AY, Kapitskaya KY, Altukhov IA, Semashko TA, Alexeev DG, Govorun VM. Transcriptome analysis reveals novel regulatory mechanisms in a genome-reduced bacterium. Nucleic Acids Res. 2014 Dec 1;42(21):13254-68. doi: 10.1093/nar/gku976. Epub 2014 Oct 31. PubMed PMID:25361977; PubMed Central PMCID: PMC4245973.

  • Gorbachev AY, Fisunov GY, Izraelson M, Evsyutina DV, Mazin PV, Alexeev DG, Pobeguts OV, Gorshkova TN, Kovalchuk SI, Kamashev DE, Govorun VM. DNA repair in Mycoplasma gallisepticum. BMC Genomics. 2013 Oct 23;14:726. doi:10.1186/1471-2164-14-726. PubMed PMID: 24148612; PubMed Central PMCID:PMC4007778.

  • Mazin P, Xiong J, Liu X, Yan Z, Zhang X, Li M, He L, Somel M, Yuan Y, Phoebe, Chen YP, Li N, Hu Y, Fu N, Ning Z, Zeng R, Yang H, Chen W, Gelfand M, Khaitovich P. Widespread splicing changes in human brain development and aging. Mol Syst Biol. 2013;9:633. doi: 10.1038/msb.2012.67. PubMed PMID: 23340839; PubMed Central PMCID: PMC3564255.

  • Mazin PV, Gelfand MS, Mironov AA, Rakhmaninova AB, Rubinov AR, Russell RB, Kalinina OV. An automated stochastic approach to the identification of the protein specificity determinants and functional subfamilies. Algorithms Mol Biol. 2010 Jul 15;5:29. doi: 10.1186/1748-7188-5-29. PubMed PMID: 20633297; PubMed Central PMCID: PMC2914642.

Master of science in Biology. Diploma “Prediction of substrate specificity in protein families”, supervisor: O.V. Kalinina. Department of Bioengineering and Bioinformatics, Moscow State University, Moscow, Russia, 2008

 

  • Prediction of specificity determining positions in multiple protein alignments

  • Computational analysis of alternative splicing

  • Bacterial transcriptomics

 

  • 05.2012 – the Award of Invitro company
  • 06.2012 – the Russian Federation President Stipend for young scientists. “Gene markers for early diagnosis of neurodegenerative disorders”