olgasergeeva

Olga Sergeeva

Senior Research Scientist
Center of Life Sciences

Olga graduated from Chemistry Department, Moscow State University in 2008 and defended PhD thesis in bioorganic chemistry at the Moscow State University in 2012.

During her postgraduate studies, Olga worked in the Max Plank Institute for Biophysical Chemistry in Gottingen, Germany. In 2014-2015 Olga as a Skoltech research scientist visited Koch Institute for integrative cancer research, MIT in Boston, USA.

Olga received several scientific awards and research grants, and published a number of papers in peer-reviewed journals.

 

- new long-noncoding RNAs and its potenitial application like a probable target and therapy

– chemical modification of the potential theraputic nucleic acids

– new regulators of the cell translation process in vivo

Selected publications:

1. O. Sergeeva, Hammond, P. Melnikov, L. Goli, J. Stoodley, T. Zatsepin, D. Stetsenko, M. Wood. Mesyl Phosphoramidate Oligonucleotides as Potential Splice Switching Agents: Impact of Backbone Structure on Activity and Intracellular Localization. Nucl Acids Ther. 2021. 31:190-200.

2. O. Sergeeva, T. Abakumova, I. Kurochkin, R. Ialchina, A. Kosyreva, T. Prikazchikova, V. Varlamova, E. Shcherbinina, T. Zatsepin. Level of Murine DDX3 RNA Helicase Determines Phenotype Changes of Hepatocytes In Vitro and In Vivo. Int J Mol Sci. 22:6958.

2. A. Fefilova, P. Melnikov, T. Prikazchikova, T. Abakumova, I. Kurochkin, P. Mazin, R. Zaganshin, O. Sergeeva, T. Zatsepin. Murine Long Noncoding RNA Morrbid Contributes in the Regulation of NRAS Splicing in Hepatocytes In Vitro. Int J Mol Sci. 2020. 21(16): 5605.

3. O. Sergeeva, P. Sergeev, P. Melnikov, T. Prikazchikova, O. Dontsova, T. Zatsepin. Modification of Adenosine196 by Mettl3 Methyltransferase in the 5′-External Transcribed Spacer of 47S Pre-rRNA Affects rRNA Maturation. Cells. 2020. 9(4): 1061.

4. O. Sergeeva, E. Sviridov, T. Zatsepin. Noncoding RNA in Liver Regeneration-From Molecular Mechanisms to Clinical Implications. Seminar Liv. Dis. 2020. 40(1):70-83.

5. Petrov R.A., Maklakova S.Y., Ivanenkov Y.A., Petrov S.A., Sergeeva O.V., Yamansarov E.Y., Saltykova I.V., Kireev I.I., Alieva I.B., Deyneka E.V., Sofronova A.A., Aladinskaia A.V., Trofimenko A.V., Yamidanov R.S., Kovalev S.V., Kotelianski V.E., Zatsepin T.S., Beloglazkina E.K., Majouga A.G. Synthesis and biological evaluation of novel mono- and bivalent ASGP-R-targeted drug-conjugates. Bioorg Med Chem Lett. 2017. S0960-894X(17): 31192-7.

 

 

2012 PhD in Bioorganic Chemistry “Enzymatic properties of rRNA methyltransferase RsmD Escherichia coli”, Department of Chemistry, M.V.Lomonosov Moscow State University

2008 M.Sc. in Chemistry, Department of Chemistry, M.V.Lomonosov Moscow State University, Summa cum laude. Thesis: Investigation of the rRNA methyltransferase complexes with its substrates.

2013 – O. V. Deripaska scholarship for talented students, Ph. D. and young scientists in MSU.

2012 – President of Russian Federation scholarship for the young scientists and graduate students engaged in advanced research and development in priority areas of Russian modernization.

2012 – Moscow State University scholarship for young scientists, who have good results in scientific career.