Supervisor: Professor Konstantin Lukyanov
Marina was graduated from the School of Biology of the Lomonosov Moscow State University. She completed her postgraduate project under supervision of Academician of the Russian Academy of Science, Professor Pavel G. Georgiev at the Institute of Gene Biology, Russian Academy of Sciences. Marina defended her thesis in the molecular genetics of Drosophila melanogaster in 2003. Later, Marina studied post-translational protein arginylation as Postdoctoral Researcher/Research Associate at the University of Pennsylvania and the University of Pittsburgh. In 2019 Marina joined Skoltech to work on development of advanced methods of fluorescence labeling and imaging of biological models.
The development of advanced methods of fluorescence labeling and imaging of biological models are focused on genetically encoded or targeted tags for visualization of specific cellular proteins and functional processes in live cells. Epigenetic modifications of chromatin play a huge role in the regulation of gene expression. Post-translational modifications of histones, such as methylation, acetylation, phosphorylation, etc., which can occur at different amino acid positions, are very important for chromatin modifications. In Skoltech Marina will focus on a development of new set of sensors based on FUCCI which allows performing realtime monitoring of interphase and cell-cycle biology in permanent fluorescence-marked cell lines.
Currently, antibiotic resistance becomes a global healthcare problem that may undermine the ability to control bacterial diseases. Marina is particularly interested in the monitoring of bacteria-host interaction by fluorescent probes and in the using of antibacterial compounds that can be developed for practical use in medicine and agriculture. The results of this work may form the basis of a strategy for obtaining fundamentally new antibiotics that ignore bacterial resistance.
Development of advanced probes for optical bioimaging
List of Publications
Rachel Smalridge (2006) A modifier of motility. Nature Reviews Molecular Cell Biology 7, 552-553.
Nailing Down the Effects of Arginylation. Editors’ Choice. (2006) Sci. STKE, tw242.
Chloe Bulinski (2006) Actin Discrimination. Science, 313(5784):180-1.
Pavel Nazarov (2017) Mankind can win the war against bacteria. Kommersant. Science 7, 552-553.
One of the best articles of 2017 (by the Ministry of Education and Science of Russia)
M. Karakozova, E. Savitskaya. Studying of mechanisms of influence on progress transposition and recombination in Drosophila melanogaster. (2002) III Congress of a biochemical society. St-Petersburg, Russia.
M. Karakozova, E. Savitskaya, P. Georgiev. The (gypsy) insulator modulates transpositions P elements in Drosophila melanogaster. (2003) International conference “Molecular genetics of eucaryotes”. p. 31. Moscow, Russia.
P. Georgiev, E. Savitskaya, M. Karakozova. The Su(Hw) insulator modulates the recombination between FRT sites and transposition P element in Drosophila melanogaster. (2003) Sixth Internetional conference on Drosophila Heterochromatin. Ravello, Italy.
M. Karakozova, M. Kozak, R. Rai, C.C.L. Wong, A.O. Bailey, J.R. Yates, A. Kashina. Arginilation of beta actin regulates actin cytoskeleton and cell motility. (2005). Gordon research conferences. Colby-Sawyer College, New London, USA.
M. Karakozova, M. Kozak, C.C.L. Wong, A. O. Bailey, J.R. Yates, A. Kashina. Posttranslational N-terminal organization regulates cell motility and actin cytoskeleton. 45th Annual Meeting. (2005) San Francisco, USA.
“Chemistry comes to the cell: ASCB 2005“ Nature Chemical Biology (2006) 2, 3, p 121.
M. Karakozova, M. Kozak, C.C.L. Wong, A. O. Bailey, J.R. Yates, Mogilner A, Zebrovski H, Kashina A. Arginylation of b-actin regulates actin cytoskeleton and cell motility. HUPO 5th Annual World Congress. (2006) Long Beach, USA.
“Proteomics attack on post-translational modifications” Medicine/Sciences 23 (2), pp. 219-220 2007.
Karakozova M., Lee M.J., Kwon Y.T.. Protein arginylation is a posttranslational modification that is effect on cardiovascular development, adhesion and motility. American Heart Association’s 17th Annual Fellows Research Day (2009). Pittsburgh, USA.
Nazarov P.A., Karakozova M.V. Application of KillerRed red fluorescent protein for evaluation of the bactericidal action of antimicrobial drugs. Scientific-practical conference of Russian and Croatian scientists. (2019) Moscow, Russia.
Nazarov P.A., Kotova E.A., Karakozova M.V., Antonenko Y.N. Membrane depolarizing antibiotics kill gram-positive and gram-negative bacteria by targeting bacterial bioenergetics. (2020) ASM Microbe 2020 (submitted).