Marina Karakozova

Research Scientist
Center of Life Sciences

Supervisor: Professor Konstantin Lukyanov

Marina was graduated from the School of Biology of the Lomonosov Moscow State University. She completed her postgraduate project under supervision of Academician of the Russian Academy of Science, Professor Pavel G. Georgiev at the Institute of Gene Biology, Russian Academy of Sciences. Marina defended her thesis in the molecular genetics of Drosophila melanogaster in 2003. Later, Marina studied post-translational protein arginylation as Postdoctoral Researcher/Research Associate at the University of Pennsylvania and the University of Pittsburgh. In 2019 Marina joined Skoltech to work on development of advanced methods of fluorescence labeling and imaging of biological models.

The development of advanced methods of fluorescence labeling and imaging of biological models are focused on genetically encoded or targeted tags for visualization of specific cellular proteins and functional processes in live cells. Epigenetic modifications of chromatin play a huge role in the regulation of gene expression. Post-translational modifications of histones, such as methylation, acetylation, phosphorylation, etc., which can occur at different amino acid positions, are very important for chromatin modifications. In Skoltech Marina will focus on a development of new set of sensors based on FUCCI which allows performing realtime monitoring of interphase and cell-cycle biology in permanent fluorescence-marked cell lines.

Currently, antibiotic resistance becomes a global healthcare problem that may undermine the ability to control bacterial diseases. Marina is particularly interested in the monitoring of bacteria-host interaction by fluorescent probes and in the using of antibacterial compounds that can be developed for practical use in medicine and agriculture. The results of this work may form the basis of a strategy for obtaining fundamentally new antibiotics that ignore bacterial resistance.

Development of advanced probes for optical bioimaging

List of Publications


  1. Karakozova M.V., Savitskaya E.E., Parshikov A.F., Georgiev P.G. (2003). Cis-modifiers of the yellow gene repression induced by the Su(Hw) insulator in the absence of the Mod(mdg4) protein in Drosophila melanogaster. Dokl Biochem Biophys., 389, 110-113.
  2. SavitskayaE., Karakozova M., Parshikov A., Georgiev P. (2004) The role of Su(Hw) and Mod(Mdg4) proteins in the Su(Hw) insulators pairing revealed by FRT site-specific recombination in Drosophila melanogaster. Advance in Molecular cell biology. 164-172. Moscow.
  3. Karakozova M., Savitskaya E., Melnikova L., Parshikov A., Georgiev P. (2004) The Mod(mdg4) component of the Su(Hw) insulator inserted in the P transposon can repress its mobility in Drosophila melanogaster. Genetics, 167(3):1275-80.
  4. Kostyuchenko M.V., Savitskaya E.E., Karakozova M.V., Georgiev P.G. (2005) Study of the regulatory region of gene white of Drosophila melanogaster. Dokl Biochem Biophys., 405, 383-387.
  5. Karakozova M., Kozak M., Wong C.C., Bailey A.O., Yates J.R. 3rd, Mogilner A., Zebroski H., Kashina A. (2006) Arginylation of beta-actin regulates actin cytoskeleton and cell motility. Science, 313(5784):192-6.


    Rachel Smalridge (2006) A modifier of motility. Nature Reviews Molecular Cell Biology 7, 552-553.

    Nailing Down the Effects of Arginylation. Editors’ Choice. (2006) Sci. STKE, tw242.

    Chloe Bulinski (2006) Actin Discrimination. Science, 313(5784):180-1.

  6. Kostyuchenko M., Savitskaya E., Koryagina E., Melnikova L., Karakozova M., Georgiev P. (2009) Zeste can facilitate long-range enhancer-promoter communication and insulator bypass in Drosophila melanogaster. Chromosoma, 118(5):665-74.
  7. Krivega M., Savitskaya E., Krivega I., Karakozova M., Parshikov A., Golovnin A., Georgiev P. (2010) Interaction between a pair of gypsy insulators or between heterologous gypsy and Wari insulators modulates Flp site-specific recombination in Drosophila melanogaster. Chromosoma, 119(4):425-34.
  8. Kozlov E.N., Martynova E.U., Roshchina N.V., Karakozova M.V., Mukha D.V. (2016) Expression of cDNA of the Gene for the Capsid Protein VP2 of German Cockroach Densovirus in the Transgenic Strain of Drosophila melanogaster. Russian Journal of Genetics 52, 4, 505-508.
  9. Nazarov P.A., Osterman I.A., Tokarchuk A.V., Karakozova M.V., Korshunova G.A., Lyamzaev K.G., Skulachev M.V., Kotova E.A., Skulachev V.P., Antonenko Y.N. (2017) Mitochondria-targeted antioxidants as highly effective antibiotics, Scientific Reports 7 (1), 1394.


    Pavel Nazarov (2017) Mankind can win the war against bacteria. Kommersant. Science 7, 552-553.

    One of the best articles of 2017 (by the Ministry of Education and Science of Russia)

  10. Karakozova M.V., Nazarov P.A. (2018) Conserved sequences of genes coding for the multidrug resistance pump AcrAB-TolC of Escherichia coli suggest their involvement into permanent cell “cleaning”. Bulletin of Russian State Medical University, 7, 2, 32-36.
  11. Nazarov P.A., Kirsanov R.S., Denisov S.S., Khailova L.S., Karakozova M.V., Lyamzaev K.G., Korshunova G.A., Lukyanov K.A., Kotova E.A., Antonenko Y.N. (2020) Fluorescein derivatives as antibacterial agents acting via membrane depolarization. Biomolecules, Feb 15;10(2). pii: E309.

Selected abstracts

M. Karakozova, E. Savitskaya. Studying of mechanisms of influence on progress transposition and recombination in Drosophila melanogaster. (2002) III Congress of a biochemical society. St-Petersburg, Russia.

M. Karakozova, E. Savitskaya, P. Georgiev. The (gypsy) insulator modulates transpositions P elements in Drosophila melanogaster. (2003) International conference “Molecular genetics of eucaryotes”. p. 31. Moscow, Russia.

P. Georgiev, E. Savitskaya, M. Karakozova. The Su(Hw) insulator modulates the recombination between FRT sites and transposition P element in Drosophila melanogaster. (2003) Sixth Internetional conference on Drosophila Heterochromatin. Ravello, Italy.

M. Karakozova, M. Kozak, R. Rai, C.C.L. Wong, A.O. Bailey, J.R. Yates, A. Kashina. Arginilation of beta actin regulates actin cytoskeleton and cell motility. (2005). Gordon research conferences. Colby-Sawyer College, New London, USA.

M. Karakozova, M. Kozak, C.C.L. Wong, A. O. Bailey, J.R. Yates, A. Kashina. Posttranslational N-terminal organization regulates cell motility and actin cytoskeleton. 45th Annual Meeting. (2005) San Francisco, USA.


 “Chemistry comes to the cell: ASCB 2005“ Nature Chemical Biology (2006) 2, 3, p 121.

M. Karakozova, M. Kozak, C.C.L. Wong, A. O. Bailey, J.R. Yates, Mogilner A, Zebrovski H, Kashina A. Arginylation of b-actin regulates actin cytoskeleton and cell motility. HUPO 5th Annual World Congress. (2006) Long Beach, USA.


“Proteomics attack on post-translational modifications” Medicine/Sciences 23 (2), pp. 219-220 2007.


Karakozova M., Lee M.J., Kwon Y.T.. Protein arginylation is a posttranslational modification that is effect on cardiovascular development, adhesion and motility. American Heart Association’s 17th Annual Fellows Research Day (2009). Pittsburgh, USA.

Nazarov P.A., Karakozova M.V. Application of KillerRed red fluorescent protein for evaluation of the bactericidal action of antimicrobial drugs. Scientific-practical conference of Russian and Croatian scientists. (2019) Moscow, Russia.

Nazarov P.A., Kotova E.A., Karakozova M.V., Antonenko Y.N. Membrane depolarizing antibiotics kill gram-positive and gram-negative bacteria by targeting bacterial bioenergetics. (2020) ASM Microbe 2020 (submitted).