mariasokolova

Maria Sokolova

Assistant Professor
Center of Life Sciences

Maria Sokolova graduated with honors from Peter the Great St. Petersburg Polytechnic University in 2013 (Master of Science in Physics). In 2014, Maria started her postgraduate studies at Skoltech, supervised by prof. Konstantin Severinov. In June 2018 Maria defended her Ph.D. thesis “Functional and structural analysis of a non-canonical multisubunit RNA polymerase encoded by giant bacteriophage AR9” which was evaluated as a research project of the highest caliber.

As a research scientist at the Center of Life Sciences, Maria continued her work on structural and functional characterization of non-canonical viral RNA polymerases. Maria’s research on novel RNA polymerases has a clear basic science value and may provide novel enzymes for biotechnology. Maria’s broad scientific interests are in the molecular mechanisms of protein-DNA interactions and the ways how these mechanisms have been evolving.

In August 2018 Maria took the initiative to organize and lead the undergraduate summer practical school “Search for antibiotics produced by bacteria” that was a highly successful one according to students’ enthusiastic and excited responses.

  • Structural and functional characterization of non-canonical viral RNA polymerases
  • Organization and leading annual schools for undergraduate students
  • Development, approbation, and delivery of Master and PhD level practical laboratory courses on “Molecular machines” and a research seminar on the same topic

A non-canonical multisubunit RNA polymerase encoded by the AR9 phage recognizes the template strand of its uracil-containing promoters. Sokolova M, Borukhov S, Lavysh D, Artamonova T, Khodorkovskii M, Severinov K. Nucleic Acids Res. 2017 Jun 2;45(10):5958-5967. doi: 10.1093/nar/gkx264.

 Transcription Profiling of Bacillus subtilis Cells Infected with AR9, a Giant Phage Encoding Two Multisubunit RNA Polymerases. Lavysh D, Sokolova M, Slashcheva M, Forstner KU, Severinov K.В MBio. 2017 Feb 14;8(1). pii: e02041-16. doi: 10.1128/mBio.02041-16.

The genome of AR9, a giant transducing Bacillus phage encoding two multisubunit RNA polymerases. Lavysh D, Sokolova M, Minakhin L, Yakunina M, Artamonova T, Kozyavkin S, Makarova KS, Koonin EV, Severinov K. Virology.В 2016 May 26;495:185-196. doi: 10.1016/j.virol.2016.04.030.

Grants:

RFBR mol_a  14-04-32389

Investigation of TIP49 eukaryotic proteins

2014-2015

Maria Sokolova participated in  Science and Technology in Society Forum (STS forum)

Maria Sokolova organized and led Skoltech summer school

Conference participation:

Transcription Strategy of a Giant Bacteriophage AR9 and Characterization of Its Non-Canonical Multisubunit RNA Polymerase.

Mechanism and Regulation of Prokaryotic Transcription, Federation of American Societies for Experimental Biology (FASEB), Saxtons River, VT, USA, 25-30 June 2017

Transcription Strategy of a Giant Bacteriophage AR9 and Characterization of Its Non-Canonical Multisubunit RNA Polymerase.

22nd Structural Biology Symposium, Sealy Center for Structural Biology and Molecular Biophysics Symposium, The University of Texas Medical Branch, TX, USA, 6 May 2017

 A non-canonical multisubunit RNA polymerase encoded by the AR9 phage recognizes the template strand of its uracil-containing promoters.

29th  RNA Polymerase Workshop, Newcastle University, UK,  6-7 April 2017

Functional analysis of AR9 bacteriophage and characterization of its non-canonical multisubunit RNA polymerase.

Bacteriophages: Theoretical and Practical Aspects of Their Application in Medicine, Veterinary and Food, Moscow, Russia, 13-15 October 2016

2nd place for the Poster Session

 Functional analysis of AR9 bacteriophage and characterization of its non-canonical multisubunit RNA polymerase.

Interdisciplinary School and Conference “Information Technologies and Systems” ITAS, Saint-Petersburg, Russia, 25-30 September 2016

 Unusual RNA polymerases encoded by the PBS1 phage.

76th Harden Conference: Total Transcription, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 1-5 September 2014

 

Internships:

February 2017 – December 2017, Studying of the AR9 RNA polymerase structure at Petr Leiman`s laboratory at The University of Texas Medical Branch, TX, USA

https://scsb.utmb.edu/faculty/Leiman.asp