konstantinseverinov



Personal Websites

Konstantin Severinov

Professor, Director of the Center of Life Sciences
Center of Life Sciences

Konstantin is a professor at the Molecular Biology and Biochemistry department at Rutgers University, New Brunswick, and a head of laboratory at the Waksman Institute for Microbiology. He also heads a Laboratory of genetic regulation of prokaryotic mobile genetic elements at the Institute of Molecular Genetics at the Russian Academy of Sciences and a Laboratory of molecular genetics of microorganisms at the Institute of Gene Biology at the Russian Academy of Sciences.

He is a member of the Science and Technology Council of the Russian Nanotechnology corporation and a consultant for 7 biotech companies and several Russian government agencies. He has produced over 200 peer-reviewed publications and 6 patents.

Konstantin works on genetic, biochemical, and structural analyses of transcription mechanism and regulation in bacteria. He also studies the regulation of macromolecular synthesis during the process of bacteriophage infection and various molecular interactions between bacteriophages and their host bacteria. Another main direction of his research involves analysis of antibacterial peptides called microcins: their structures, mechanisms of function, evolution, and the use as new antibiotics.

  • Bacterial viruses, bacteriophages, are most abundant and diverse live objects on our planet. They evolved a trove of mechanisms to destroy bacteria. Bacteriophages can also be used directly as antibacterial agents. We identify new bacteriophages from environment, determine their genomic sequences and identify molecular mechanisms that they use to effectively infect bacterial hosts. The knowledge gained produces targets for future development of antibacterial drugs.
  • Adaptive bacterial immunity CRISPR-Cas systems have revolutionized the field of genomic editing and opened up possibilities for genomic medicine. In collaboration with laboratories from NIH and MIT we predict and functionally characterize new CRISPR-Cas systems that may have advantages over existing ones in practical applications. We also study the biological role of various CRISPR-Cas systems, trying to understand how they shape the interactions of bacteria with mobile genetic elements such as bacteriophages and impact bacterial ecology and evolution. To this end, we a combination of advanced biochemical, genetic, biophysical and bioinformatics methods.
  • Antibiotic resistance becomes a global healthcare problem that may undermine the humankind ability to control bacterial diseases. We use bioinformatics to search for new antibiotics by mining available genomic and metagenomic data and we experimentally validate predicted antibiotic biosynthesis clusters and characterise new antibiotics they encode.  We determine the structures of validated compounds, mechanisms of their biosynthesis and action on sensitive cells. The knowledge gained is used to create semisynthetic bioactive compounds that can be developed for practical use in medicine and agriculture.
  • Skoltech Professor of the year (2018)
  • Russian Web of Science Award (2017)
  • Best Research Supervisor, Skoltech award (2017)
  • Russian Scopus Award (2015)
  • Fulbright Senior Scholar (2010)
  • Fellow of American Academy of Microbiology (2009)
  • The Russian Science Support Foundation Prize (2008, 2009)
  • Doctor of Sciences, Russian Academy of Sciences, cum laude, (2006)
  • 10th Johnson & Johnson Discovery Award (1997)
  • The Burroughs Welcome Fund Career Award in Biomedical Sciences (1996-2002)
ekaterinasavitskaya
Ekaterina Savitskaya
Senior Research Scientist
dariaartamonova
Daria Artamonova
Research Scientist
Svetlana Dubiley
Head of Biomedical Teaching Laboratory
ignatgoryanin
Ignat Goryanin
Research Scientist
artemisaev
Artem Isaev
PhD student
ishitajain
Ishita Jain
PhD student
evgenyklimuk
Evgeny Klimuk
Research Scientist
andreykrivoy
Andrey Krivoy
PhD student
alexeykulikovsky
Alexey Kulikovsky
Laboratory Engineer
annamaikova
Anna Maikova
PhD student
alexandermartynov
Alexander Martynov
PhD student
sofyamedvedeva
Sofya Medvedeva
PhD student
annapavlova
Anna Moroz
PhD student
olgamusharova
Olga Musharova
Research Scientist
juliapiskunova
Julia Piskunova
Research Scientist
nataliarubanova
Natalia Rubanova
PhD student
annashiriaeva
Anna Shiriaeva
PhD student
dariaslonova
Darya Slonova
PhD student
mariasokolova
Maria Sokolova
Research Scientist
brendanwilcox
Brendan Wilcox
PhD student
yuliazhitnyuk
Yulia Zhitnyuk
PhD student
tatianazyubko
Tatiana Zyubko
PhD student
ianafedorova
Iana Fedorova
Junior Research Scientist
victorfedorchuk
Victor Fedorchuk
Research Intern
victormamontov
Victor Mamontov
PhD student
nataliamorozova
Natalia Morozova
Research Intern
dmitrysutormin
Dmitry Sutormin
PhD student
dmitriitravin
Dmitrii Travin
PhD student
daryatsibulskaya
Darya Tsibulskaya
Research Intern
  • Advanced Molecular Biology Laboratory Practice
This course offers students the opportunity to work individually on laboratory projects assigned by the course instructor. During the term students are expected to have at least one entire working day in the lab, although additional days may be required. Final grades are determined by the students’ final presentations, which describe their project/goals along with the results/progress accomplished. Participation in the course requires approval from the students’ own advisors, as well as the instructors of the course.
  • Molecular Biology Seminar
For each class, there will be a paper that two people will present to the rest of the class. We will go down to the details of experiments – how things were done and what do the data/figures really show, so be prepared to answer in-depth questions. Presenters will start by stating the name of the paper/main authors and telling the take home message of the paper – why it is signficant, what problem it solved. Then they will proceed to the actual work. If there are methods/results mentioned in the paper that refer to prior work, you shall be prepared to answer questions about it too. The audience is supposed to read the paper being discussed beforehand and participate in discussions.To pass, one would need to present a paper at least once during the module and actively take part in discussions of other papers. One absence is allowed no questions asked. Additional absences when unexplained will be a cause for no-pass grade. There will be a few home assignments. They must be submitted in time, typed–not written up–and done professionally (written in good language, be concise and free of spelling errors – consider them as part of academic writing exercises).It is gonna be fun – students tend to like the seminar and its atmospher.

1. “How can we change availability of the modern medicine genomic analysis?”, 17/11/2014

2. “Gene transcription”, 05/11/2014

3. “Protein folding”, 17/10/2014

4. “Genetic variations in bacteria”, 14/10/2014

5. Talk about the principles of sugar substitutes, experiments with laboratory mice and human microbiota, 13/10/2014

6. “Transfer of the biological signals”, 09/10/2014

7. “How does the mammal’s intestinal microflora protection mechanism works?”, 03/10/2014

8. “Macromolecules interactions”, 01/09/2014

9. Talk about the problems of biology teaching at school, 20/08/2014

10. “Systems biology and antibiotics crisis”, 04/07/2014

11. “Science sexism”, 04/06/2014

12. “Structural and functional regulation features of the bacterial transcription”, 17/05/2014

13. “How does the DNA with synthetic nucleotides has been built into a living cell?”, 13/05/2014

14. Talk about the scientific infrastructure, relationship between viruses and bacteria, and the main motivation of scientists, 30/04/2014

15.  “Why do we need bioinformatics?”, 23/12/2013

16.  “Genetic noise”, 26/11/2013

17. “Coevolution of humans and bacteria”, 15/11/2013

18. “Synthetic microbiology” 06/11/2013

19. “Gene therapy”, 03/09/2013

20. Talk about the photosynthesis process, oxidant problems, oxygen storage and transport proteins, 06/07/2013

21. Talk about the future of RAS, 02/07/2013

22. “Recommendations: 5 books about genetics”, 29/06/2013

23. “Microbiota of the human”, 08/05/2013

24. “Mitochondrial Eve”, 24/04/2013

25. Talk about the hemoglobin, 04/03/2014

ФИО: Северинов Константин Викторович

Занимаемая должность (должности): Директор ЦНИО

Преподаваемые дисциплины: Лабораторный курс “Базовые методы в молекулярной биологии”

Ученая степень: Доктор биологических наук, 2007; Кандидат биологических наук, 1993 Институт молекулярной генетики РАН Москва

Ученое звание (при наличии): Профессор по специальности “Молекулярная генетика”

Наименование направления подготовки и/или специальности: Биохимия

Данные о повышении квалификации и/или профессиональной переподготовке (при наличии): нет

Общий стаж работы: 25 лет

Стаж работы по специальности: 25 лет