ilyaaparin



Personal Websites

www.researchgate.net/profile/Ilya_Aparin

Ilya Aparin

Junior Research Scientist
Center of Life Sciences

Professor: Timofei Zatsepin

I graduated from Chemistry department of Lomonosov Moscow State University (MSU) in 2012 with MSc in chemistry. After that, I moved to the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences (IBCh RAS), where I received PhD degree in bioorganic chemistry. Last 5 years my research was primarily focused on fluorescent labels, conjugates of synthetic oligonucleotides and DNA probes as well as modified monoclonal antibodies for molecular diagnostics. I have a 10 years’ experience in synthetic organic chemistry, in particular from 2013 to 2018 I worked in LLC Biotech-Innovations (Lumiprobe) as a research associate where I performed development and synthesis of reagents for molecular biology, reactive derivatives of diverse fluorophores and modified monomers for oligonucleotide synthesis.

Industrial project with Generium LLC devoted to enhanced therapeutic RNAs with improved nuclease stability and intracellular distribution.

  1. Aparin I.O., Proskurin G.V., Golovin A.V., Ustinov A.V., Formanovsky A.A., Zatsepin T.S., Korshun V.A. Fine Tuning of pyrene excimer fluorescence in molecular beacons by alteration of the monomer structure. J. Org. Chem., 2017, 82(19), 10015‑10024.
  2. Farzan V.M., Ulashchik E.A., Martynenko-Makaev Y.V., Kvach M.V., Aparin I.O., Brylev V.A., Prikazchikova T.A., Maklakova S.Y., Majouga A.G., Ustinov A.V., Shipulin G.A., Shmanai V.V., Korshun V.A., Zatsepin T.S. Automated solid phase click synthesis of oligonucleotide conjugates: from small molecules to diverse N-acetylgalactosamine clusters. Bioconjug. Chem., 2017, 28(10), 2599–2607.
  3. Aparin I.O., Farzan V.M., Veselova O.A., Chistov A.A., Podkolzin A.T., Ustinov A.V., Shipulin G.A., Formanovsky A.A., Korshun V.A. and Zatsepin T.S. 1-Phenylethynylpyrene (PEPy) as a novel blue-emitting dye for qPCR assay. Analyst, 2016, 141(4), 1331–1338.
  4. Tsybulsky D.A., Kvach M.V., Ryazantsev D.Y., Aparin I.O.*, Stakheev A.A., Prokhorenko I.A., Martynenko Y.V., Gontarev S.V., Formanovsky A.A., Zatsepin T.S., Shmanai V.V., Korshun V.A., Zavriev S.K. Molecular beacons with JOE dye: Influence of linker and 3′ couple quencher. Mol. Cell. Probes, 2016, 30(5), 285–290.
  5. Farzan V.M., Aparin I.O., Veselova O.A., Podkolzin A.T., Shipulin G.A., Korshun V.A., Zatsepin T.S. Cy5/BHQ dye–quencher pairs in fluorogenic qPCR probes: effects of charge and hydrophobicity. Anal. Methods, 2016, 8(29), 5826–5831.
  6. Chistov A.A., Kutyakov S.V., Ustinov A.V., Aparin I.O., Glybin A.V., Mikhura I.V., Korshun V.A. 2-Ethynylperylene and improved synthesis of 3-ethynylperylene. Tetr. Lett., 2016, 57(9), 1003–1005.
  7. Aparin I.O., Chistov A.A., Prokhorenko I.A., Stepanova I.A., Veselova O.A., Ustinov A.V., Formanovsky A.A., Zatsepin T.S., Korshun V.A. Blue-emitting fluorescent azides for DNA labeling. Collection Symp. Ser., 2014, 14, 222‑224.

09.2007 – 06.2012    MSc in organic chemistry. Lomonosow Moscow State University (MSU).

10.2012 – 03.2018    PhD in bioorganic chemistry. Institute of Bioorganic Chemistry of the Russian Academy of Sciences (IBCh RAS).