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Arsen Mikaelyan

Professor: Timofei Zatsepin

Arsen graduated in Biology from Yerevan State University in 1983, and defended his Candidate of Science degree in Genetics at the Koltsov Institute of Developmental Biology of the Russian Academy of Sciences in 1998.

Arsen has exceptional experience with modern molecular and cell biology techniques required for success of the suggested research project, specifically in the field of hepatocellular carcinoma. Arsen has obtained extensive international experience while working at the National Cancer Institute (USA), Johns Hopkins University (USA) and University of Chicago (USA)).  For the last several years Arsen has been leading his own research group within Laboratory of Regeneration at the Institute of Developmental Biology where he will keep his job while also working part-time at Skoltech.

The role of ubiquitin proteasome system in liver cancer progression:

the main purpose of this project is to validate ubiquitin ligases of the N-end rule pathway as new targets for anti-cancer therapy.

  1. Dolgilevich, S. M., Knyaseva, M. V., Mikaelian, A. S., and Gause, G. G.: Isolation and some characteristics of chromosome gene, coding for the frog rho crystallin. Doklady Rossiiskoi Akademii Nauk. 392: 449 452, 1988.
  2. Dolgilevich, S. M., Mikaelyan, A. S., Knyaseva, M. V., Snegovaya, I. Yu., Simirskii, V. N., Aleinikova, K. S., and Gause, G. G.: Rho crystallin of the frog lens: structure and expression. Doklady Rossiiskoi Akademii Nauk. 335: 373 377, 1994.
  3. Dolgilevch, S. M., Snegovaya, I. Yu, and Mikaelyan, A. S.: Taxon specific protein of the frog lens: phylogenetic relatedness with the family of NADPH dependent reductases. Biology Bulletin – Izvestiya Akademii Nauk. Series Biological. No. 4: 577 587, 1994.
  4. Mitashov, V. I., Lukyanov, S. A., Kasanskaya, O. V., Markitantova, Yu., V., Dolgilevich, S. M., Snegovaya, I. Yu., Znoiko, S. L., and Mikaelyan, A. S.: Molecular biological approaches to the studies of gene expression during regeneration. Biology Bulletin, Izvestiya Akademii Nauk, Series Biological, No. 3: 280 284, 1995.
  5. Kasanskaya, O. V., Markitantova, Yu. V., Snegovaya, I. Yu., Dolgilevich, S. M., Tarabykin, V., Zaraisky, A., Luk’yanov, S. A., Znoiko, S. L., Mikaelyan, A. S., and Mitashov, V. I.: Identification of new genes and analysis of their expression during lens and retina regeneration in adult newts. Biology Bulletin, Izvestiya Akademii Nauk, Series Biological, No. 3: 271-275, 1995.
  6. Mikaelyan, A. S., Znoiko, I. Yu., and Zinovieva, R. D.: Crystallins: recruitment of proteins for new functions. Ontogenez (Russian Journal of Developmental Biology) 30: 325 340, 1999.
  7. Mikaelyan, A., Lee, J-S., Conner, E. A., Factor, V. M. and Thorgeirsson, S. S.: Global gene expression analysis identifies distinct molecular pathways of HCC in mouse models of liver cancer. Proceedings of AACR, 2003, 44: 1172-1173
  8. Mitashev VI, Koussoulakos S, Zinov’eva RD, Ozerniuk ND, Mikaelian AS, Shmukler EIu, Smirnova IuA. Constructive synergism of regulatory genes expressed in the course of the eye and muscle development and regeneration. Izv Akad Nauk Ser Biol. 2001, (3): 261-75. Review. Russian.
  9. Kaposi-Novak P, Lee JS, Mikaelyan A, Patel V, Thorgeirsson SS. Oligonucleotide microarray analysis of aminoallyl-labeled cDNA targets from linear RNA amplification. Biotechniques. 2004, 37(4):580, 582-6, 588.
  10. Lee JS, Chu IS, Mikaelyan A, Calvisi DF, Heo J, Reddy JK, Thorgeirsson SS. Application of comparative functional genomics to identify best-fit mouse models to study human cancer. Nat Genet. 2004, 36(12):1306-11.
  11. Lee JS, Heo J, Libbrecht L, Chu IS, Kaposi-Novak P, Calvisi DF, Mikaelyan A, Roberts LR, Demetris AJ, Sun Z, Nevens F, Roskams T, Thorgeirsson SS. A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells. Nat Med. 2006, 12(4):410-6.
  12. Birukova AA, Malyukova I, Mikaelyan A, Fu P, Birukov KG. Tiam1 and betaPIX mediate Rac-dependent endothelial barrier protective response to oxidized phospholipids. J Cell Physiol. 2007, 211(3):608-17.
  13. Birukova AA, Alekseeva E, Mikaelyan A, Birukov KG. HGF attenuates thrombin-induced endothelial permeability by Tiam1-mediated activation of the Rac pathway and by Tiam1/Rac-dependent inhibition of the Rho pathway. FASEB J. 2007, 21(11):2776-86.
  14. Kozhevnikova MN, Mikaelian AS, Starostin VI. Molecular and genetic regulation of osteogenic differentiation of mesenchymal stromal cells. Izv Akad Nauk Ser Biol. 2008, (3):261-71.
  15. Kozhevnikova MN, Mikaelian AS, Paiushina OV, Starostin VI. Comparative characterization of mesenchymal bone marrow stromal cells at early and late stages of culturing. Izv Akad Nauk Ser Biol. 2008, (2):156-62. Russian.
  16. Kozhevnikova MN, Mikaelyan AS, Starostin VI. Comparative immune-phenotypic and functional characteristics of mesenchymal stromal cells from definitive and transitory hematopoietic organs. Dokl Biol Sci. 2008, 422:363-5.
  17. Kozhevnikova MN, Mikaelian AS, Starostin VI. Molecular genetic and immunophenotypic analysis of antigen profiling, osteogenic and adipogenic potentials of mesenchymal stromal cells from fetal liver and adult bone marrow in rats. Tsitologiia. 2009, 51(6):526-38. Russian.
  18. Kuzin BA, Modestova EA, Vorontsova IuE, Zatsepina OG, Mikaelian AS, Slezinger MV, Simonova OB. Interaction of the ss and CG5017 genes in the regulation of morphogensis of limbs in Drosophila melanogaster. Ontogenez. 2010, 41(5):364-9. Russian.
  19. Zinevich LS, Mikaelyan AS. Igf1 expression in mouse model of liver carcinogenesis. Dokl Biochem Biophys. 2012, 442:1-3.
  20. Zinevich LS, Goncharova NO, Uruvaeva IV, Delone GV, Mikaelian AS.: Igf-1 and its isoform expression in hepatic cell tumors and the surrounding tissue in mice liver carcinogenesis induced by diethylnitrozamine. Izv Akad Nauk Ser Biol. 2013, (6):673-81. Russian
  21. Ilina, I. V., Ovchinnikov, A. V., Sitnikov, D. S., Chefonov, O. V., Agranat, M. B., & Mikaelyan, A. S. (2013, June). Noncontact microsurgery of living cell membrane using femtosecond laser pulses. In European Conferences on Biomedical Optics(pp. 88030A-88030A). International Society for Optics and Photonics.
  22. Il’ina, I. V., Ovchinnikov, A. V., Sitnikov, D. S., Chefonov, O. V., & Agranat, M. B. (2014). Noncontact microsurgery and delivery of substances into stem cells by means of femtosecond laser pulses. Quantum Electronics, 44(6), 594.
  23. Kosykh, A., Ngamjariyawat, A., Vasylovska, S., Konig, N., Trolle, C., Lau, J., Mikaelyan A….. & Kozlova, E. N. (2015). Neural crest stem cells from hair follicles and boundary cap have different effects on pancreatic islets in vitro. International Journal of Neuroscience, 125(7), 547-554.
  24. Dashenkova, N., and A. Mikaelyan. “A129: Analysis of Igf axis in development of HCC.” European Journal of Cancer Supplements 13.1 (2015): 11-12.
  25. Kopantseva, M. R., Usova, E., Mikaelyan, A., Kostina, M., Melekhina, O., Egorov, V., & Kopantzev, E. P. (2015). Effect of IGF1 on cancer and stromal cells of human pancreatic tumors. Cancer Research, 75(15 Supplement), 1540-1540.
  26. .O. Dashenkova, O.S. Petrakova, A.A.Tsitrina, A.S. Mikaelyan. Characteristics of primary cultures of mouse hepatocellular carcinoma and evaluation of their potential to undergo epithelial-mesenchymal transition. THE JOURNAL OF CLINICAL AND EXPERIMENTAL MORPHOLOGY, 2017, № 3(23): 44-49.
  27. IV Uryvaeva, AS Mikaelyan, NO Dashenkova, TL Marshak. Chromothripsis in hepatocarcinogenesis: the role of micronuclear aberration and polyploidy. Izv Akad Nauk Ser Biol. (2018) in press.

1983    M.Sci., Biology, Yerevan State University, Armenia, USSR.

1998    Ph.D., Genetics, Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia. Thesis: Structural-functional characteristics of rho-crystallin gene in frog Rana temporaria.

Advisor: Dr. R.D. Zinovieva.