Alexander Tyshkovskiy
Supervisor: Philipp Khaitovich, co-advisor: Vadim Gladyshev, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA.
Entry year to Skoltech – 2014
Graduated with distinction from Lomonosov Moscow State University, Department of Bioengineering and Bioinformatics.
Research project: “Molecular Signatures and Mechanisms behind Lifespan Extension”
The project is aimed to identification of molecular signatures associated with longevity both across- and within the species. We use long-lived rodent naked mole rat fibroblasts model for investigation of gene expression signatures linked to it remarkable resistance to DNA damage. To identify signatures associated with longevity within the certain species, we study effect of lifespan-extending interventions on gene expression and methylation changes with age in mouse. Such project may bring us closer to the understanding of mechansisms of longevity control and even facilitate discovery of new antiaging therapies.
I am doing my PhD project in the laboratory of Vadim Gladyshev in Brigham and Women’s Hospital, Harvard Medical School, Boston. Here is the link to lab web site:
http://gladyshevlab.bwh.harvard.edu/.
Participation in conferences
EMBO at BASEL LIFE, Basel, Switzerland, 2018:
Poster: Gene expression analyses across lifespan-extending interventions identify the associated molecular mechanisms.
Mechanisms and Organizing Principles in Redox Signaling – Implications for Age-Related Disease, Gordon Research Conference, Castelldefels, Spain, 2018:
Poster: Glutathione metabolism and NRF2 pathway are common gene expression signatures of lifespan-extending interventions.
Mechanisms of aging, Cold Springs Harbor Laboratory, 2016:
Poster: Gene expression analyses across lifespan-extending interventions identify the associated molecular mechanisms
Russian corporations, universities and science: problems and perspectives of collaboration in innovation sphere (organized by Rostekhnologii State Corporation), 2012:
Report: Identification of a new cell antioxidative defense participant and its contribution to enhancement of biotechnological processes productivity – conference award for the best report
XVIII International conference of students, graduate students and young scientists ‘Lomonosov-2011’:
Report: Correlation between gene expression level changes during oxidative stress response and content of amino acids in coding proteins in Saccharomyces cerevisiae cells – conference award for the best report
IV International molecular genetics school of young scientists Genomics and Cell Biology, 2010:
Report: Telomerase as a marker and target in oncogenesis
XVII International conference of students, graduate students and young scientists ‘Lomonosov-2010’:
Poster: Telomerase as a potential marker for kidney cancer diagnostics
Diploma - My diploma work in Moscow State University was called “Development of mathematical model of TRPV1 channels activation and regulation on peripheral ends of nociceptors and its application for identification of potential analgesia candidates” and was done under supervision of Dr. Oleg Demin in Institute for Systems Biology (ISB).
Tyshkovskiy A., Borodinova A., Khaitovich P., Miller R.A., Gladyshev V.N. (2018). Identification and application of gene expression signatures of lifespan-extending interventions. Submitted to Cell.
Sziráki A., Tyshkovskiy A., and Gladyshev V.N. (2018). Global remodeling of the mouse DNA methylome during aging and in response to calorie restriction. Aging Cell e12738.
Zhao Y.*, Tyshkovskiy A.*, Muñoz-Espín D., Tian X., Serrano M., de Magalhaes J.P., Nevo E., Gladyshev V.N., Seluanov A., and Gorbunova V. (2018). Naked mole rats can undergo developmental, oncogene-induced and DNA damage-induced cellular senescence. Proc. Natl. Acad. Sci. 115, 1801–1806.
* Authors contributed equally to this work
Nomination for Presidential Award for Young Scientists in Fields of Science and Innovation, 2014
Semifinalist of MIT$100K Entrepreneurship Competition Pitch contest, Cambridge, 2013-2014
Russian Government Fellowship, 2012-2013
Russian Government Fellowship, 2011-2012