alekseimikhalchenko

Aleksei Mikhalchenko

PhD student

PhD Research project: “Molecular signatures of lifespan control based on comparative analysis of mammalian iPS cells”

Supervisor: Dr. Philipp Khaitovich, Co-advisor: Dr. Vadim Gladyshev, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA

Entry year to Skoltech – 2014

Aging process differs dramatically among different species of mammals, leading to difference of more than 100 fold in lifespan. During my PhD project, I’m going to test a hypothesis that induced pluripotent stem cells (iPSCs) will reflect lifespan of mammalian species. For unbiased comparison among mammals I will use iPS cells from these animals. Analysis of gene expression and metabolic parameters of iPS cells from different mammals would allow their comparison at the level of “ground state”.

The project is being doing in the laboratory of Dr. Vadim Gladyshev, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA.

http://gladyshevlab.bwh.harvard.edu/

Master (Specialist) degree from Lomonosov Moscow State University, Faculty of Bioengineering and Bioinformatics

Diploma work:

Title: “Allelic imbalance and microsatellite instability in rare types of kidney tumors.”

Supervisor: Dr. Dmitriy Mikhaylenko,  Dr. Dmitriy Zaletayev.

O.I. Apolikhin, D.S. Mikhaylenko, A.E. Mikhalchenko, D.V. Zaletayev, G.D. Efremov, A.V. Sivkov. “Molecular-genetic alterations as criteria in differential diagnostics of rare renal tumors”. Experimental & Clinical Urology (№ 3  2013), p. 21-27.

Grant: RFBR 12-04-31005 “Searching of molecular-genetic markers of a  papillary renal cell carcinoma” (2012-2013)

Presentations:
Retreat and External Advisory Committee Meeting: Comparatives Genomics of Longevity Program Project Grant; Rochester, NY (2015):
“Molecular signatures of lifespan control based on comparative analysis of mammalian iPS cells”.

Retreat and External Advisory Committee Meeting: Comparatives Genomics of Longevity Program Project Grant; Rochester, NY (2016):
“Molecular signatures of lifespan control based on comparative analysis of mammalian iPS cells”