Yury Kostyukevich

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Yury Kostyukevich

Research Scientist
Space Center

Professor: Evgeny Nikolaev

Yury completed his postgraduate studies in Chemical Physics at the Moscow Institute for Physics and Technology defending his thesis at the Semenov Institute of Chemical Physics of Russian Academy of Sciences. He developed a novel ion trap for the ion cyclotron resonance mass spectrometer. The patent for the invention is owned by Bruker Corporation. He developed a simple method for structural investigation of biomolecules based on gas phase ion-molecular reactions combined with ultrahigh resolution mass spectrometry. He discovered the presence of multiple gas-phase conformations of oligosaccharides ions. He made a considerable contribution to the investigation of structure of individual molecules of natural organic matter (oil, humic substances).

Yury Kostyukevich participated in many proteomics projects including investigation of proteome of urine and exhaled breath condensate. He was an exchange student in the Laboratory of Organic Chemistry in ETH, Zurich and visited many universities.

Publications:

Kostyukevich Y., Kononikhin A., Zherebker A., Popov I., Perminova I., Nikolaev E. Enumeration of non-labile oxygen atoms in dissolved organic matter by use of 16O/18O exchange and Fourier transform ion-cyclotron resonance mass spectrometry // Analytical and Bioanalytical Chemistry – 2014 – DOI 10.1007/s00216-014-8097-9. (IF = 3.6)

Perminova I.,  Dubinenkov I., Kononikhin A., Konstantinov A., Zherebker A., Andzhushev M., Lebedev V., Bulygina E., Holmes R.,Kostyukevich Y., Popov I., Nikolaev E. Molecular Mapping of Sorbent Selectivities with Respect to Isolation of Arctic Dissolved Organic Matter as Measured by Fourier Transform Mass Spectrometry // Environmental Science & Technology – 2014. – V.48. – N.13. – P.7461-7468DOI: 10.1021/es5015423 (IF=5.2)

Kostyukevich Y., Kononikhin A., Popov I., Starodubtzeva N., Kukaev E., Nikolaev E. Letter: Separation of tautomeric forms of [2-Nitrophloroglucinol-H]- by in-ESI source Hydrogen/deuterium exchange approach. // European Journal of Mass Spectrometry – 2014. – doi: 10.1255/ejms.1282 (IF=1.1)

Popov I., Nagornov K., Vladimirov G.,Kostyukevich Y., Nikolaev E. Twelve Million Resolving Power on 4.7 T Fourier Transform Ion Cyclotron Resonance Instrument with Dynamically Harmonized Cell—Observation of Fine Structure in Peptide Mass Spectra // Journal of the American Society for Mass Spectrometry. – 2014. – V. 25. – N. 5. – P. 790-799. (IF=4.0)

Nikolaev E.,Kostyukevich Y., Vladimirov G. Fourier transform ion cyclotron resonance (FT ICR) mass spectrometry: Theory and simulations // Mass Spectrometry Reviews. – 2014. – Early View. (IF=7.7)

Kostyukevich Y., Kononikhin A., Popov I., Nikolaev E. In-ESI source Hydrogen/Deuterium exchange of carbohydrates ions // Analytical Chemistry. – 2014. – V. 86. – N. 15. – P. 2595-2600. (IF=5.7)

Kostyukevich Y., Kononikhin A., Popov I., Kharybin O., Perminova I., Konstantinov A., Nikolaev E. Enumeration of labile hydrogens in natural organic matter using hydrogen/deuterium exchange Fourier Transform Ion Cyclotron Resonance mass spectrometry // Analytical Chemistry. – 2013. – V. 85. – N. 22. – P. 11007-11013. (IF=5.7)

Popov I., Starodubtseva N., Indeikina M.,Kostyukevich Y., Kononikhin A.,  Nikolaeva M., Kukaev E., Kozin, S., Makarov A., Nikolaev E. Mass spectrometric identification of posttranslational modifications in transthyretin from human blood // MOLECULAR BIOLOGY. – 2013. – V.47 – N. 6 – P. 885-893. (IF=0.8)

Kononikhin A., Huang M., Popov I.,Kostyukevich Y., Kukaev E., Boldyrev A., Spasskiy A., Leypunskiy I., Shiea J., Nikolaev E. Signal enhancement in electrospray laser desorption/ionization mass spectrometry by using a black oxide-coated metal target and a relatively low laser fluence // European Journal of Mass Spectrometry. – 2013. – V.19. – N. 4. – P. 247-252. (IF=1.1)

Kostyukevich Y., Kononikhin A., Popov I., Nikolaev E. Simple Atmospheric Hydrogen/Deuterium Exchange Method for Enumeration of Labile Hydrogens by Electrospray Ionization Mass Spectrometry // Analytical Chemistry. – 2013. – V. 85. – N. 11. – P. 5330-5334 (IF=5.7)

Kostyukevich Y., Vladimirov G., Nikolaev E. Dynamically Harmonized FT-ICR Cell with Specially Shaped Electrodes for Compensation of Inhomogeneity of the Magnetic Field. Computer Simulations of the Electric Field and Ion Motion Dynamics // Journal of the American Society for Mass Spectrometry. – 2012. – V. 23. – N. 12. – P. 2198-2207. (IF=4.0)

Kostyukevich Y., Umanskii S. Dependence of the molecular iodine B-state predissociation induced by a femtosecond laser pulse on pulse phase modulation // Quantum Electronics. –  2011. – V.41 – N.12 – P.1104-1108. (IF=0.8)

Patents:

Nikolaev E.,Kostyukevich Y., Vladimirov G. EP Patent No. 2706557 A2 (11 Sep 2012).

Kostyukevich Y., Vladimirov G., Nikolaev E. US Patent No. 20140070090 A1 (11 Sep 2012).

Application of mass-spectrometers for near-Earth space research including development of novel instrumentation (ion funnels, vacuum chambers etc.)

Zhvansky E., Shurkhay V., Popov, I., Bormotov D., Indeikina, M.I., Karchugina S., Kostyukevich Y., Kononikhin, A., Bugrova A., Starodubtseva, N., Potapov A. & Nikolaev, E. A novel direct spray-from-tissue ionization method for mass spectrometric analysis of human brain tumors”, has been accepted for publication in Analytical and Bioanalytical Chemistry. The manuscript will now be forwarded to the production manager. Anal Bioanal Chem (2015).

  1. Zherebker, A.Y., Airapetyan, D., Konstantinov, A.I., Kostyukevich, Y.I., Kononikhin, A.S., Popov, I.A., Zaitsev, K.V., Nikolaev, E.N. & Perminova, I.V. Synthesis of model humic substances: a mechanistic study using controllable H/D exchange and Fourier transform ion cyclotron resonance mass spectrometry. Analyst140, 4708-19 (2015).
  2. Kostyukevich Y., Kononikhin, A., Popov, I. & Nikolaev, E. Conformations of cationized linear oligosaccharides revealed by FTMS combined with in-ESI H/D exchange. Journal of Mass Spectrometry (2015).
  3. Vladimirov G., Kostyukevich Y., Hendrickson C., Blakneye G. & E., N. Effect of magnetic field inhomogeneity on ion cyclotron motion coherence at high magnetic field. European Journal of Mass Spectrometry (2015).
  4. Kostyukevich, Y., Zhdanova, E., Kononikhin, A., Popov, I., Kukaev, E. & Nikolaev, E. Observation of the multiple halogenation of peptides in the electrospray ionization source. Journal of Mass Spectrometry50, 899-905 (2015).
  5. Kostyukevich, Y., Kononikhin, A., Popov, I., Starodubtzevad, N., Pekov, S., Kukaev, E., Indeykina, M. & Nikolaev, E. Letter: Analytical potential of the in-electrospray ionization source hydrogen/deuterium exchange for the investigation of oligonucleotides. Eur J Mass Spectrom (Chichester, Eng)21, 59-63 (2015).
  6. Kostyukevich, Y., Kononikhin, A., Popov, I., Spasskiy, A. & Nikolaev, E. In ESI-source H/D exchange under atmospheric pressure for peptides and proteins of different molecular weights from 1 to 66 kDa: the role of the temperature of the desolvating capillary on H/D exchange. J Mass Spectrom50, 49-55 (2015).
  7. Kostyukevich, Y., Kononikhin, A., Popov, I. & Nikolaev, E. Letter: Observation of the (16)O/(18)O exchange during electrospray ionization. Eur J Mass Spectrom (Chichester, Eng)21, 109-13 (2015).
  8. Kostyukevich, Y., Kononikhin, A., Popov, I., Indeykina, M., Kozin, S.A., Makarov, A.A. & Nikolaev, E. Supermetallization of peptides and proteins during electrospray ionization. JournalofMassSpectrometry50, 1079-1087 (2015).
  9. Стародубцева Н.Л., Вавина О.В., Ходжаева З.С., КононихинА.С., Попов И.А., Бугрова А.Е., УсмановаЗ.И., Костюкевич Ю.И., Высоких М.Ю., КанН.Е., Николаев Е.Н. & Г.Т., С. Создание методов сравнительного протеомного анализа мочи беременных и небеременных женщин для исследования процессов, протекающих при беременности. Акушерство и Гинекология, 41-48 (2014).
  10. Popov, I.A., Nagornov, K., Vladimirov, G.N., Kostyukevich, Y.I. & Nikolaev, E.N. Twelve million resolving power on 4.7 T Fourier transform ion cyclotron resonance instrument with dynamically harmonized cell–observation of fine structure in peptide mass spectra. J Am Soc Mass Spectrom25, 790-9 (2014).
  11. Popov, I.A., Indeikina, M.I., Pekov, S.I., Starodubtseva, N.L., Kononikhin, A.S., Nikolaeva, M.I., Kukaev, E.N., Kostyukevich, Y.I., Kozin, S.A., Makarov, A.A. & Nikolaev, E.N. Estimation of phosphorylation level of amyloid-beta isolated from human blood plasma: Ultrahigh-resolution mass spectrometry. Molecular Biology48, 607-614 (2014).
  12. Perminova, I.V., Dubinenkov, I.V., Kononikhin, A.S., Konstantinov, A.I., Zherebker, A.Y., Andzhushev, M.A., Lebedev, V.A., Bulygina, E., Holmes, R.M., Kostyukevich, Y.I., Popov, I.A. & Nikolaev, E.N. Molecular mapping of sorbent selectivities with respect to isolation of Arctic dissolved organic matter as measured by Fourier transform mass spectrometry. Environ Sci Technol48, 7461-8 (2014).
  13. Nikolaev, E.N., Kostyukevich, Y.I. & Vladimirov, G.N. Fourier transform ion cyclotron resonance (FT ICR) mass spectrometry: Theory and simulations. Mass Spectrom Rev (2014).
  14. Kostyukevich, Y., Kononikhin, A., Zherebker, A., Popov, I., Perminova, I. & Nikolaev, E. Enumeration of non-labile oxygen atoms in dissolved organic matter by use of (1)(6)O/ (1)(8)O exchange and Fourier transform ion-cyclotron resonance mass spectrometry. Anal Bioanal Chem406, 6655-64 (2014).
  15. Kostyukevich, Y., Kononikhin, A., Popov, I., Starodubtseva, N., Kukaev, E. & Nikotaev, E. Separation of tautomeric forms of [2-nitrophloroglucinol-H]- by an in-electrospray ionization source hydrogen/deuterium exchange approach. Eur J Mass Spectrom (Chichester, Eng)20, 345-9 (2014).
  16. Kostyukevich, Y., Kononikhin, A., Popov, I. & Nikolaev, E. In-ESI source hydrogen/deuterium exchange of carbohydrate ions. Anal Chem86, 2595-600 (2014).
  17. Kostyukevich, Y., Kononikhin, A., Popov, I. & Nikolaev, E. Conformational changes of ubiquitin during electrospray ionization as determined by in-ESI source H/D exchange combined with high-resolution MS and ECD fragmentation. J Mass Spectrom49, 989-94 (2014).
  18. Popov, I.A., Starodubtseva, N.L., Indeikina, M.I., Kostyukevich, Y.I., Kononikhin, A.S., Nikolaeva, M.I., Kukaev, E.N., Kozin, S.A., Makarov, A.A. & Nikolaev, E.N. Mass spectrometric identification of posttranslational modifications in transthyretin from human blood. Molecular Biology47, 885-893 (2013).
  19. Kostyukevich, Y., Kononikhin, A., Popov, I. & Nikolaev, E. Simple atmospheric hydrogen/deuterium exchange method for enumeration of labile hydrogens by electrospray ionization mass spectrometry. Anal Chem85, 5330-4 (2013).
  20. Kostyukevich, Y., Kononikhin, A., Popov, I., Kharybin, O., Perminova, I., Konstantinov, A. & Nikolaev, E. Enumeration of labile hydrogens in natural organic matter by use of hydrogen/deuterium exchange Fourier transform ion cyclotron resonance mass spectrometry. Anal Chem85, 11007-13 (2013).
  21. Kononikhin, A., Huang, M.Z., Popov, I., Kostyukevich, Y., Kukaev, E., Boldyrev, A., Spasskiy, A., Leypunskiy, I., Shiea, J. & Nikolaev, E. Signal enhancement in electrospray laser desorption/ionization mass spectrometry by using a black oxide-coated metal target and a relatively low laser fluence. Eur J Mass Spectrom (Chichester, Eng)19, 247-52 (2013).
  22. Kostyukevich, Y.I., Vladimirov, G.N. & Nikolaev, E.N. Dynamically harmonized FT-ICR cell with specially shaped electrodes for compensation of inhomogeneity of the magnetic field. Computer simulations of the electric field and ion motion dynamics. J Am Soc Mass Spectrom23, 2198-207 (2012).
  23. Kostyukevich, Y.I. & Umanskii, S.Y. Dependence of the molecular iodine B-state predissociation induced by a femtosecond laser pulse on pulse phase modulation. QuantumElectronics41, 1104-1108 (2011).

Patents:

Костюкевич Ю., Кононихин А., Попов И., Кукаев Е., Стародубцева Н. & Е., Н. СПОСОБ ПРОВЕДЕНИЯ ДЕЙТЕРО-ВОДОРОДНОГО ОБМЕНА В ИОННОМ ИСТОЧНИКЕ МАСС-СПЕКТРОМЕТРА. RU 2 548 387 C1 (2015).

Nikolaev, E., Y., K. & G., V. Dynamically harmonized ft-icr cell with specially shaped electrodes for compensation of inhomogeneity of the magnetic field. EP 2706557 A2 (2014).

Y., K., Nikolaev, E. & G., V. Dynamically harmonized ft-icr cell with specially shaped electrodes for compensation of inhomogeneity of the magnetic field. US20140070090 A1 (2013).

Research areas:

High resolution mass-spectrometry, proteomics and metabolomics,structural proteomics,analysis of complex biochemical mixtures, supercomputer modeling of ion cloud behavior in accumulation and transportation of ions

Principal Investigator of projects supported by grants:

  1. FASIE Grant UMNIK, 2011.
  2. Russian Foundation for Basic Research (RFBR) Grant for young researchers “My first grant”, 2013.
  3. Russian Foundation for Basic Research (RFBR) Initiative Grant, 2014.