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Waltraud Mair

Professor: Philipp Khaitovich

Waltraud obtained her Bachelor degree in Molecular Biotechnology from Ruprecht-Karls-University Heidelberg, Germany, in 2008, and her Master degree in Systems Biology from   the Swiss Federal Institute of Technology (ETH) Zurich, Switzerland, in 2011. During her Master thesis she worked in the laboratory of Prof. Ruedi Aebersold on the analysis of the cell surface proteomic changes occurring during influenza virus infection of human cells using mass spectrometry-based proteomic techniques. Waltraud received her doctoral degree at the Department of Proteomics and Bioanalytics, Technical University Munich, Germany, in joint collaboration with the Department of Neurobiology at Children’s Hospital Boston / Harvard Medical School, Boston, US. Her research focused on the mass-spectrometry-based global proteomics as well as targeted analysis of Tau protein post-translational modifications involved in neurodegenerative diseases, such as Alzheimer’s Disease. In April 2016 she defended her thesis titled “Quantitative Studies of Tau Protein and Tauopathy”.

During her studies, she worked as researcher at the German Cancer Research Center (DKFZ), Heidelberg, Germany; the Babraham Institute, Cambridge, UK; and the Butantan Institute, São Paulo, Brazil. She was awarded the Willi-Studer Prize for best overall degree of the year in the Biology Master program, and her research resulted in several papers in peer-reviewed journals.

Waltraud will lead the establishment of a high-throughput mass spectrometry-based metabolomics and lipidomics platform. Using various LC-MS/MS techniques, the pipeline will be applied for global lipid profiling and the identification of lipid and metabolic biomarkers in a variety of research projects with biomedical, clinical, and agricultural relevance in the fields of neurobiology, human evolution, crop breeding and animal biosecurity, among others.

Silva CM, Cheng C, Mair W, Almeida S, Fong H, Biswas H, Zhang Z, Huang Y, Temple S, Coppola G, Geschwind DH, Karydas A, Miller BL, Kosik KS, Gao F, Steen JA, Haggarty SJ. “Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability”, accepted in Stem Cell Reports, 2016 July 12

Mair W, Muntel J, Tepper K, Tang S, Kosik KS, Seeley WW, Mandelkow EM, Mandelkow E, Steen H, Steen JA. “FLEXiTau: Quantifying Hyperphosphorylation of Tau in vitro and in Human Disease”, Anal. Chem. 2016 88 (7), 3704-3714 (PMC26877193)

Zhang X, Hernandez I, Rei D, Mair W, Laha JK, Cornwell ME, Cuny GD, Tsai LH, Steen JA, Kosik KS. “Diaminothiazoles modify Tau phosphorylation and improve the tauopathy in mouse models.” J Biol Chem. 2013 Jul 26 (PMC3724657)

Stergiou L, Bauer M, Mair W, Bausch-Fluck D, Drayman N, Wollscheid B, Oppenheim A, Pelkmans L. “Integrin-mediated signaling induced by simian virus 40 leads to transient uncoupling of cortical actin and the plasma membrane.” PLoS One. 2013 (PMC3567119)

Smyrnias I, Mair W, Harzheim D, Walker SA, Roderick HL, Bootman MD. “Comparison of the T-tubule system in adult rat ventricular and atrial myocytes, and its role in excitation-contraction coupling and inotropic stimulation.” Cell Calcium. 2010 Mar (PMC20106523)

2011 – 2016
PhD, Department of Proteomics and Bioanalytics
Technical University Munich (TUM), Germany
In joint collaboration with the Department of Neurology, Boston Children’s Hospital / Harvard Medical School, Boston, US

2008 – 2010
Master of Science in Biology, Major Systems Biology (with distinction)
Swiss Federal Institute of Technology Zurich (ETH Zurich), Switzerland

2005 – 2008
Bachelor of Science in Molecular Biotechnology
Ruprecht‐Karls University, Heidelberg, Germany

  • Molecular System’s Biology
  • Global and targeted mass spectrometry-based approaches (e.g. LC-MS/MS, selected monitoring (SRM))
  • Proteomics, metabolomics and lipidomics
  • Neurodegenerative diseases
  • Tau protein and tauopathies
  • Post-translational modifications

Willi-Studer Prize, ETH Zurich

Best overall degree in the Master program Biology (valedictorian of the year)