victorkotelianski

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Victor Kotelianski

Victor received his doctor of science degree from the National Cardiology Research Center of the Russian Academy of Medical Science in Moscow, and then went on to serve as the Institute’s professor of cell biology.

He was senior scientist at the Institute of Protein Research, Russian Academy of Science in Poustchino. He received his Ph.D. in molecular biology from the Russian Academy of Sciences and his doctor of medicine degree from the Uzhgorod University Medical School. He joined Alnylam in 2003 as vice president of research and was promoted to senior vice president, Distinguished Alnylam Fellow in 2008. He was formerly Distinguished Investigator, Director of Biological Research at Biogen (now Biogen Idec) and earlier in his career he served as Director of Research, Institut National de la Sante et de la Reserche Medicale (INSERM) in Paris. He has over 150 publications.

  • RNAi thereapeutics, including ALN-RSV01, ALN-VSP, and ALN-PCS
Functional Genomics

Number of ECTS credits: 3
Course Classification: Science, Technology, and Engineering

Course description:
The course emphasizes functional genomics as essential element of drug discovery, target verification and mechanistic evaluation of drug action. It covers all aspects of the field: basic methods in integrative physiology and contemporary imaging methods on molecular, cellular, organ and whole animal levels. Cardiovascular, renal, pulmonary, immunological, neural and cancer models will be discussed with illustration of major in vivo protocols.
The goal of the course is to give the students with biological, chemical, physical, mathematical and engineering background the in-depth knowledge and understanding unraveling causative factors of disease and targeted intervention using genetic intervention and integrative physiology approach.

Prerequisites:
High through put analysis of transcriptome, principles of genetic modifications, various vectors for transgenes, specific recombination in ES cells (reporter knock ins, knockouts, conditionsl knockouts) , genome editing (TALEN, CRISPR). Special attention is given to RNAi translational medicine.

Genetic Animal Models and Integrative Physiologyin Drug Discovery
Number of ECTS credits: 3
Course Classification: Science, Technology, and Engineering

Course Description:
The course emphasizes genetic in vivo models as essential element of drug target discovery, verification and mechanistic evaluation. It covers all aspects of the field: principles of genetic modifications, various vectors for transgenes, specific recombination in ES cells (reporter knock ins, knockouts, conditionsl knockouts) , genome editing (TALEN, CRISPR). Special at attention is given to RNAi translational medicine. It also gives basic methods in integrative physiology and contemporary imaging methods on molecular, cellular, organ and whole animal levels. Cardiovascular, renal, pulmonary, immunological, neural and cancer models will be discussed with illustration of major in vivo protocols.
The goal of the course is to give the students with biological, chemical, physical, mathematical and engineering background the in-depth knowledge and understanding unraveling causative factors of disease and targeted intervention using genetic intervention and integrative physiology approach .

Intended Learning Outcomes:
Genetic engineering, gene targeting, gene editing in ES cells and in the embryo.
Transgenesis using different experimental platforms.
RNAi technology in gene silencing
Analysis of physiological phenotypes in vivo.
Evaluation of complex physiological experiments on transgenic, knock down models with good understanding of biomedical physiology of the mouse.
This course will be sufficient minimum to join the lab at a PhD student/Junior postdoc level working in biomedicine/translational medicine

 

ФИО: Котелянский Виктор Елизарович
Занимаемая должность (должности): Профессор
Преподаваемые дисциплины: Генномодифицированные модели животных в поиске и создании новых лекарств
Ученая степень: Кандидат биологических наук, 1976, Академия медицинских наук, Москва, Д-р биологических наук 1984, Академия медицинских наук, Москва
Ученое звание (при наличии): Профессор по специальности “Клеточная биология”
Наименование направления подготовки и/или специальности: Клеточная биология
Данные о повышении квалификации и/или профессиональной переподготовке (при наличии): нет
Общий стаж работы: 43 года
Стаж работы по специальности: 43 года