Professor: Timofei Zatsepin
Valentina graduated from Kazan (Volga region) Federal University in 2011. Her diploma research was devoted to the influence of hydration on the receptor properties of beta-cyclodextrins in mass detectors. After graduation, Valentina joined the Laboratory of Analytical studies for Ecological and Environmental Monitoring (Institute of Management of Ecological and Subsurface Problems, Kazan, Russian Federation), where she conducted research in the field of limnology.
In 2013, Valentina joined Central Research Institute of Epidemiology, Moscow, as a Production Associate, where she worked on the oligonucleotide synthesis and led the effort that resulted in the application of novel dyes for qPCR probes. She also made a valuable contribution to the development of fast and robust procedure for oligonucleotide analysis by LC-MS.
During her part-time Junior Researcher appointment in the Laboratory of Tissue-specific Ligands (Chemistry Department, Lomonosov Moscow State University) in 2015, Valentina worked with the conjugation of reactive modified oligonucleotides (DNA, RNA) with small molecules (including GalNAc and metal complexes), purification of oligonucleotides and conjugates by RP HPLC and oligonucleotide quality control using LC-MS.
At Skoltech, Valentina works in the research group of Professor Victor Kotelianski on the project “Development of Synthesis of modified RNA conjugates for therapy.”
Development of synthesis of modified RNA conjugates with small molecules, including N-galactosamine (asiaglycoprotein receptor in hepatocytes), mannose and folic acid (mannose and folate receptors in macrophages) and ligands for PSMA receptor (prostate specific membrane antigene)