ilyaosterman

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Ilya Osterman

Leading Research Scientist
Center for Translational Biomedicine

Professor: Olga Dontsova

Dr Ilya Osterman is a researcher at the Department of Chemistry, Lomonosov Moscow State University.  Ilya finished MSU in 2009 and started his PhD project in the field of RNA modifications. In 2012 he received his PhD degree and became a researcher at the Department of Chemistry. Dr. Osterman is a winner of many prestigious prizes for young scientists, the European Academy prize, the medal of Russian Academy of Science and prize of Russian Government among them.​

The main subject of Ilya work refers to RNA-protein complexes in bacteria. During PhD project, he systematically studied how structural variations in 5’-UTR and other features of bacterial genes including Shine-Dalgarno sequence (SD), distinct start codons, A/U-rich regions, mRNA secondary structure, codon usage, organization of genes in the operons affect the efficiency of translation.
Ilya created screening approaches to identify new antibiotics and recently characterized a number of translation inhibitors with novel chemical scaffolds. One of them,  Amicoumacin A was characterized in detail, including structure determination (in collaboration by Tom Steitz, the Nobel prize winner for structure of ribosome). These studies vividly demonstrated the fundamental and drug discovery impacts of the new methodology. Recently, Ilya started work with eukaryotic cells, he is trying to find the targets for the putative methyltransferases and to investigate their function, by means of genome editing with CRISP-Cas9 system in cell lines and in mice.
​At Skoltech, Ilya works in the area of eukaryotic genome editing and continues  screening of new translation inhibitors
  1. Osterman IA, Khabibullina NF, Komarova ES, Kasatsky P, Kartsev VG, Bogdanov AA, Dontsova OA, Konevega AL, Sergiev PV, Polikanov YS. Madumycin II inhibits peptide bond formation by forcing the peptidyl transferase center into an inactive state (2017). Nucleic Acids Res
  2. Nazarov PA, Osterman IA, Tokarchuk AV, Karakozova MV, Korshunova GA, Lyamzaev KG, Skulachev MV, Kotova EA, Skulachev VP, Antonenko YN. Mitochondria-targeted antioxidants as highly effective antibiotics. 2017 Scientific Reports. May 3;7(1):1394.
  3. Komarova (Andreyanova), E.S., Osterman, I.A., Pletnev, P.I., Ivanenkov, Y.A., Majouga, A.G., Bogdanov, A.A., Sergiev, P.V. 2-Guanidino-quinazolines as a novel class of translation inhibitors (2017) Biochimie, 133, pp. 45-55.
  4. Evfratov SA*, Osterman IA*, Komarova ES*, Pogorelskaya AM, Rubtsova MP, Zatsepin TS, Semashko TA, Kostryukova ES, Mironov AA, Burnaev E, Krymova E, Gelfand MS, Govorun VM, Bogdanov AA, Sergiev PV, Dontsova OA. Application of sorting and next generation sequencing to study 5′-UTR influence on translation efficiency in Escherichia coli(2017). Nucleic Acids Res. Apr 7;45(6):3487-3502. * Authors contributed equally to this work
  5. Osterman, I.A., Komarova, E.S., Shiryaev, D.I., Korniltsev, I.A., Khven, I.M., Lukyanov, D.A., Tashlitsky, V.N., Serebryakova, M.V., Efremenkova, O.V., Ivanenkov, Y.A., Bogdanov, A.A., Sergiev, P.V., Dontsova, O.A. Sorting out antibiotics’ mechanisms of action: A double fluorescent protein reporter for high-throughput screening of ribosome and DNA biosynthesis inhibitors (2016) Antimicrobial Agents and Chemotherapy, 60 (12), pp. 7481-7489.
  6. Sergiev, P.V., Osterman, I.A., Golovina, A.Y., Andreyanova, E.S., Laptev, I.G., Pletnev, P.I., Evfratov, S.A., Marusich, E.I., Leonov, S.V., Ivanenkov, Y.A., Bogdanov, A.A., Dontsova, O.A. Application of reporter strains for screening of new antibiotics (2016) Biochemistry (Moscow)
  7. Prokhorova, I.V., Akulich, K.A., Makeeva, D.S., Osterman, I.A., Skvortsov, D.A., Sergiev, P.V., Dontsova, O.A., Yusupova, G., Yusupov, M.M., Dmitriev, S.E. Amicoumacin A induces cancer cell death by targeting the eukaryotic ribosome (2016) Scientific Reports, 6, art. no. 27720, .
  8. Sergiev, P.V., Golovina, A.Y., Osterman, I.A., Nesterchuk, M.V., Sergeeva, O.V., Chugunova, A.A., Evfratov, S.A., Andreianova, E.S., Pletnev, P.I., Laptev, I.G., Petriukov, K.S., Navalayeu, T.I., Koteliansky, V.E., Bogdanov, A.A., Dontsova, O.A. N6-Methylated Adenosine in RNA: From Bacteria to Humans (2016) Journal of Molecular Biology, 428 (10), pp. 2134-2145.
  9. Beloglazkina, E.K., Manzheliy, E.A., Moiseeva, A.A., Maloshitskaya, O.A., Zyk, N.V., Skvortsov, D.A., Osterman, I.A., Sergiev, P.V., Dontsova, O.A., Ivanenkov, Y.A., Veselov, M.S., Majouga, A.G. Synthesis, characterisation, cytotoxicity and antibacterial activity of ruthenium(II) and rhodium(III) complexes with sulfur-containing terpyridines (2016) Polyhedron, 107, pp. 27-37.
  10. Sergiev, P.V., Osterman, I.A., Golovina, A.Y., Andreyanova, E.S., Laptev, I.G., Pletnev, F.I., Evfratov, S.A., Marusich, E.I., Veselov, M.S., Leonov, S.V., Ivanenkov, Y.A., Bogdanov, A.A., Dontsova, O.A. High throughput screening platform for new inhibitors of protein biosynthesis (2016) Moscow University Chemistry Bulletin, 71 (1), pp. 65-67.
  11. Sergiev, P.V., Osterman, I.A., Golovina, A.Ya., Laptev, I.G., Pletnev, P.I., Evfratov, S.A., Marusich, E.I., Leonov, S.V., Ivanenkov, Ya.A., Bogdanov, A.A., Dontsova, O.A. Application of reporter strains for new antibiotic screening (2016) Biomeditsinskaya Khimiya, 62 (2), pp. 117-123.
  12. Osterman, I.A., Dikhtyar, Yu.Yu., Bogdanov, A.A., Dontsova, O.A., Sergiev, P.V. Regulation of flagellar gene expression in Bacteria (2015) Biochemistry (Moscow), 80 (11), pp. 1447-1456.
  13. Pletnev, P., Osterman, I., Sergiev, P., Bogdanov, A., Dontsova, O. Survival guide: Escherichia coli in the stationary phase (2015) Acta Naturae, 7 (4), pp. 22-33.
  14. Veselov, M.S., Sergiev, P.V., Osterman, I.A., Skvortsov, D.A., Golovina, A.Ya., Andreyanova, E.S., Laptev, I.G., Pletnev, P.I., Evfratov, S.A., Marusich, E.I., Leonov, S.V., Ivanenkov, Y.A., Bogdanov, A.A., Dontsova, O.A. Common features of antibacterial compounds: An analysis of 104 compounds library (2015) Biomeditsinskaya Khimiya, 61 (6), pp. 785-790.
  15. Osterman, I.A., Evfratov, S.A., Dzama, M.M., Pletnev, P.I., Kovalchuk, S.I., Butenko, I.O., Pobeguts, O.V., Golovina, A.Y., Govorun, V.M., Bogdanov, A.A., Sergiev, P.V., Dontsova, O.A. A bacterial homolog YciH of eukaryotic translation initiation factor eIF1 regulates stress-related gene expression and is unlikely to be involved in translation initiation fidelity (2015) RNA Biology, 12 (9), pp. 966-971.
  16. Zukher, I., Novikova, M., Tikhonov, A., Nesterchuk, M.V., Osterman, I.A., Djordjevic, M., Sergiev, P.V., Sharma, C.M., Severinov, K. Ribosome-controlled transcription termination is essential for the production of antibiotic microcin C (2014) Nucleic Acids Research, 42 (19), pp. 11891-11902.
  17. Polikanov, Y.S.*, Osterman, I.A.*, Szal, T., Tashlitsky, V.N., Serebryakova, M.V., Kusochek, P., Bulkley, D., Malanicheva, I.A., Efimenko, T.A., Efremenkova, O.V., Konevega, A.L., Shaw, K.J., Bogdanov, A.A., Rodnina, M.V., Dontsova, O.A., Mankin, A.S., Steitz, T.A., Sergiev, P.V. Amicoumacin A Inhibits Translation by Stabilizing mRNA Interaction with the Ribosome (2014) Molecular Cell, 56 (4), pp. 531-540. * Authors contributed equally to this work
  18. Prokhorova, I.V.*, Osterman, I.A.*, Burakovsky, D.E., Serebryakova, M.V., Galyamina, M.A., Pobeguts, O.V., Altukhov, I., Kovalchuk, S., Alexeev, D.G., Govorun, V.M., Bogdanov, A.A., Sergiev, P.V., Dontsova, O.A.Modified nucleotides m 2 G966/m 5 C967 of Escherichia coli 16S rRNA are required for attenuation of tryptophan operon (2013) Scientific Reports * Authors contributed equally to this work
  19. Osterman, I.A., Evfratov, S.A., Sergiev, P.V., Dontsova, O.A. Comparison of mRNA features affecting translation initiation and reinitiation (2013) Nucleic Acids Research, 41 (1), pp. 474-486.
  20. Shatskaya, G.S., Drutsa, V.L., Koroleva, O.N., Osterman, I.A., Dmitrieva, T.M. Investigation of activity of recombinant mengovirus RNA-dependent RNA polymerase and its mutants (2013) Biochemistry (Moscow), 78 (1), pp. 96-101.
  21. Osterman, I.A., Ustinov, A.V., Evdokimov, D.V., Korshun, V.A., Sergiev, P.V., Serebryakova, M.V., Demina, I.A., Galyamina, M.A., Govorun, V.M., Dontsova, O.A. A nascent proteome study combining click chemistry with 2DE (2013) Proteomics, 13 (1), pp. 17-21.
  22. Golovina, A.Y., Dzama, M.M., Osterman, I.A., Sergiev, P.V., Serebryakova, M.V., Bogdanov, A.A., Dontsova, O.A. The last rRNA methyltransferase of E. coli revealed: The yhiR gene encodes adenine-N6 methyltransferase specific for modification of A2030 of 23S ribosomal RNA (2012) RNA, 18 (9), pp. 1725-1734.
  23. Sergiev, P.V., Golovina, A.Y., Sergeeva, O.V., Osterman, I.A., Nesterchuk, M.V., Bogdanov, A.A., Dontsova, O.A. How much can we learn about the function of bacterial rRNA modification by mining large-scale experimental datasets? (2012) Nucleic Acids Research, 40 (12), pp. 5694-5705.
  24. Osterman, I.A., Prokhorova, I.V., Sysoev, V.O., Boykova, Y.V., Efremenkova, O.V., Svetlov, M.S., Kolb, V.A., Bogdanov, A.A., Sergiev, P.V., Dontsova, O.A. Attenuation-based dual-fluorescent-protein reporter for screening translation inhibitors(2012) Antimicrobial Agents and Chemotherapy, 56 (4), pp. 1774-1783.
  25. Osterman, I.A., Sergiev, P.V., Tsvetkov, P.O., Makarov, A.A., Bogdanov, A.A., Dontsova, O.A. Methylated 23S rRNA nucleotide m2G1835 of Escherichia coli ribosome facilitates subunit association (2011) Biochimie, 93 (4), pp. 725-729.

2004 – 2009                Specialist, Lomonosov MSU, Chemistry Dept, Moscow, Russia

2009 – 2012                PhD, Lomonosov MSU, Chemistry Dept, Moscow, Russia

Study of the functional role of the eukaryoyic methyltransferasas by means of genome knock-out in mice or cell lines with CRISPR-Cas9 systems. Screening and study of new antibiotics – translation inhibitors.

2010   winner of the contest of innovative projects “I5”.

2011 – RSBMB Russian Society of Biochemistry and Molecular Biology

2013 – winner of the contest “Impudent Young Promising”

2013 – winner of the European Academy prize for young scientist

2014 – winner of the grant for young biologist from Dynastia fund

2012 and 2015 – winner presidential scholarship for young scientist

2015 – winner of the contest for young scientists of the Lomonosov Moscow State University

2015 – winner of the medal of Russian academy of science for young scientists

2016 – winner of the prize of Russian government for young scientists