evgenyklimuk

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Evgeny Klimuk

Professor: Konstantin Severinov

 

 

 

Analysis of bacteriophage interactions with bacterial hosts and of phage DNA packaging in virions

Esyunina D, Klimuk E, Severinov K, Kulbachinskiy A. Distinct pathways of RNA polymerase regulation by a phage-encoded factor. P Natl Acad Sci USA. 2015 17;112(7):2017-22

Ceyssens PJ, Minakhin L, Van den Bossche A, Yakunina M, Klimuk E, Blasdel B, De Smet J, Noben JP, Bläsi U, Severinov K, Lavigne R. Development of Giant Bacteriophage ϕKZ Is Independent of the Host Transcription Apparatus. J Virol. 2014;88(18):10501-10

Klimuk E, Akulenko N, Makarova KS, Ceyssens PJ, Volchenkov I, Lavigne R, Severinov K. Host RNA polymerase inhibitors encoded by phiKMV-like phages of Pseudomonas. Virology. 2013;436(1):67-74

Pavlova O., Lavysh D., Klimuk E., Djordjevic M., Ravcheev D. A., Gelfand M. S., Severinov K., Akulenko N., Temporal regulation of gene expression of the Escherichia coli bacteriophage phiEco32. J Mol Biol. 2012;416(3):389-99.

Graf A, Kabysheva M, Klimuk E, Trofimova L, Dunaeva T, Zündorf G, Kahlert S, Reiser G, Storozhevykh T, Pinelis V, Sokolova N, Bunik V. Role of 2-oxoglutarate dehydrogenase in brain pathologies involving glutamate neurotoxicity. Journal of Molecular Catalysis B: Enzymatic 61 (2009) 80–87.

Bunik V, Kabysheva M, Klimuk E, Storozhevykh T, Pinelis V. Phosphono analogues of 2-oxoglutarate protect cerebellar granule neurons upon glutamate excitotoxicity. Ann N Y Acad Sci. 2009;1171:521-9.

2003-2008 – student, Bioengineering and Bioinformatics School, Lomonosov Moscow State University (graduated with high honours )

2008-2013 – PhD student, Bioengineering and Bioinformatics School, Lomonosov Moscow State University (graduated with degree in molecular biology)

Research interests – Transcription regulation, transcription factors, inhibitors of RNA-polymerase, bacteriophages, DNA packaging motors, CRISPR, protein-protein interactions.

Projects supported with funding:

2012-2013 – Russian foundation for basic research grant № 12-04-31069 to study inhibitors of host RNA-polymerase within phages infecting M. tuberculosis

From 2015 – grant from Dynasty Foundation to study mechanism of viral DNA packaging

From 2016 – Russian foundation for basic research grant № 16-34-60137 to study regulation of R-M system Kpn2I

2006 – Award of Academician S.E. Severin.

2011 – A winner of science & innovation contest for young researchers.

2014 – “Best poster presentation” award on “Mathematical Virology 2014” conference