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Dominique Leboeuf

Junior Research Scientist
Center for Functional Genomics

Professor: Konstantin Piatkov

Dominique graduated from the University of Montreal, Canada, majoring in Biology. She then pursued a Masters Degree at the same university, working on scoliosis, particularly on why this disease affects mostly girls.

Dominique started her research career at the Maisonneuve Rosement Hospital Research Center, in Montreal, Canada, as a Lab Manager. She worked under the leadership of Dr Martin Guimond, on the reconstitution of the immune system following T cell depletion. She published an important paper in Blood, and had the privilege of presenting this work in international meetings. As laboratory manager, she was responsible for developing projects, designing and elaborating experiments, compiling, analyzing and synthesizing results, writing and reviewing manuscripts, experimental training of students, overseeing lab function and experiments, learning, developing and teaching new techniques, lab management (ordering products and equipment) and management of mouse colonies.

The role of ubiquitin ligases Ubr2 and Ubr5 in liver cancer progression using mouse models. New approaches to regulating intracellular proteolityc activity using small interfering RNA.

Gauthier, S.-D., Leboeuf, D., Manuguerra-Gagné, R., Gaboury, L., and Guimond, M. (2015). Stromal-Derived Factor-1α and Interleukin-7 Treatment Improves Homeostatic Proliferation of Naïve CD4(+) T Cells after Allogeneic Stem Cell Transplantation. Biol. Blood Marrow Transplant. 21, 1721–1731.

Hennion-Tscheltzoff, O., Leboeuf, D., Gauthier, S.D., Dupuis, M., Assouline, B., Gregoire, A., Thiant, S., and Guimond, M. (2013). TCR triggering modulates the responsiveness and homeostatic proliferation of CD4+ thymic emigrants to IL-7 therapy. Blood 121, 4684–4693.

Thiant, S., Moutuou, M.M., Leboeuf, D., and Guimond, M. (2016). Homeostatic cytokines in immune reconstitution and graft-versus-host disease. Cytokine.

Binet, F., Mawambo, G., Sitaras, N., Tetreault, N., Lapalme, E., Favret, S., Cerani, A., Leboeuf, D., Tremblay, S., Rezende, F., et al. (2013). Neuronal ER Stress Impedes Myeloid-Cell-Induced Vascular Regeneration through IRE1α Degradation of Netrin-1. Cell Metabolism 17, 353–371.

Cerani, A., Tetreault, N., Menard, C., Lapalme, E., Patel, C., Sitaras, N., Beaudoin, F., Leboeuf, D., De Guire, V., Binet, F., et al. (2013). Neuron-Derived Semaphorin 3A Is an Early Inducer of Vascular Permeability in Diabetic Retinopathy via Neuropilin-1. Cell Metabolism 18, 505–518.

M. Sc. in Biomedical Sciences. University of Montreal, Canada. 2008

B. Sc. in Biological Sciences. University of Montreal, Canada. 2006